Herpes Simplex Viremia: Report of Eight Pediatric Cases and Review of the Literature
Bloodstream infection due to herpes simplex virus (HSV) is rare in the immunocompetent host but may be important in the pathogenesis of disseminated HSV infection in the imtnunocompromised patient. Using a simple blood-culture method, we detected herpes simplex viremia in eight immunologically compr...
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| Veröffentlicht in: | Clinical infectious diseases 1994-03, Vol.18 (3), p.401-407 |
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| container_title | Clinical infectious diseases |
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| creator | Stanberry, Lawrence R. Floyd-Reising, Shirley A. Connelly, Beverly L. Alter, Sherman J. Gilchrist, Mary J. R. Rubio, Casilda Myers, Martin G. |
| description | Bloodstream infection due to herpes simplex virus (HSV) is rare in the immunocompetent host but may be important in the pathogenesis of disseminated HSV infection in the imtnunocompromised patient. Using a simple blood-culture method, we detected herpes simplex viremia in eight immunologically compromised or immature children: two neonates, two oncology patients, and four transplant recipients. Only two patients initially exhibited evidence of mucocutaneous HSV infection. Blood was cultured for HSV because of perinatal exposure, for routine surveillance, or for the evaluation of fever, esophagitis, or oral lesions in immunocompromised patients. In five cases HSV was recovered only from the blood; in two other instances blood cultures for HSV were the first positive cultures. The time required for the detection of HSV by blood culture ranged from 1 day to 12 days. In one case viremia was transient and cleared without specific therapy. The other seven cases were treated with intravenous acyclovir; in four of these cases, therapy was initiated because of the positive blood culture. The detection of HSV in blood may promote early initiation of antiviral therapy and thereby improve prognosis. |
| doi_str_mv | 10.1093/clinids/18.3.401 |
| format | Article |
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In five cases HSV was recovered only from the blood; in two other instances blood cultures for HSV were the first positive cultures. The time required for the detection of HSV by blood culture ranged from 1 day to 12 days. In one case viremia was transient and cleared without specific therapy. The other seven cases were treated with intravenous acyclovir; in four of these cases, therapy was initiated because of the positive blood culture. The detection of HSV in blood may promote early initiation of antiviral therapy and thereby improve prognosis.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/clinids/18.3.401</identifier><identifier>PMID: 8011823</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Antiviral Agents - therapeutic use ; Blood ; Child, Preschool ; Clinical Infectious Disease Articles ; Female ; Fever ; Hepatitis ; Herpes simplex ; Herpes Simplex - complications ; Herpes Simplex - drug therapy ; Herpes Simplex - etiology ; herpes simplex virus ; Humans ; Immunocompromised Host ; Infant ; Infant, Newborn ; Infections ; Lesions ; Male ; Neoplasms - complications ; Neoplasms - immunology ; Organ Transplantation - adverse effects ; Simplexvirus ; Transplantation ; Viremia ; Viremia - complications ; Viremia - drug therapy ; Viremia - etiology ; Viruses</subject><ispartof>Clinical infectious diseases, 1994-03, Vol.18 (3), p.401-407</ispartof><rights>Copyright 1994 The University of Chicago</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3411-6f204e8128c04773374924b464c7b4fef0fb0f8ae5b8fe1d99f6a5994a4696993</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4457701$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4457701$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8011823$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stanberry, Lawrence R.</creatorcontrib><creatorcontrib>Floyd-Reising, Shirley A.</creatorcontrib><creatorcontrib>Connelly, Beverly L.</creatorcontrib><creatorcontrib>Alter, Sherman J.</creatorcontrib><creatorcontrib>Gilchrist, Mary J. R.</creatorcontrib><creatorcontrib>Rubio, Casilda</creatorcontrib><creatorcontrib>Myers, Martin G.</creatorcontrib><title>Herpes Simplex Viremia: Report of Eight Pediatric Cases and Review of the Literature</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><description>Bloodstream infection due to herpes simplex virus (HSV) is rare in the immunocompetent host but may be important in the pathogenesis of disseminated HSV infection in the imtnunocompromised patient. Using a simple blood-culture method, we detected herpes simplex viremia in eight immunologically compromised or immature children: two neonates, two oncology patients, and four transplant recipients. Only two patients initially exhibited evidence of mucocutaneous HSV infection. Blood was cultured for HSV because of perinatal exposure, for routine surveillance, or for the evaluation of fever, esophagitis, or oral lesions in immunocompromised patients. In five cases HSV was recovered only from the blood; in two other instances blood cultures for HSV were the first positive cultures. The time required for the detection of HSV by blood culture ranged from 1 day to 12 days. In one case viremia was transient and cleared without specific therapy. The other seven cases were treated with intravenous acyclovir; in four of these cases, therapy was initiated because of the positive blood culture. The detection of HSV in blood may promote early initiation of antiviral therapy and thereby improve prognosis.</description><subject>Antiviral Agents - therapeutic use</subject><subject>Blood</subject><subject>Child, Preschool</subject><subject>Clinical Infectious Disease Articles</subject><subject>Female</subject><subject>Fever</subject><subject>Hepatitis</subject><subject>Herpes simplex</subject><subject>Herpes Simplex - complications</subject><subject>Herpes Simplex - drug therapy</subject><subject>Herpes Simplex - etiology</subject><subject>herpes simplex virus</subject><subject>Humans</subject><subject>Immunocompromised Host</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infections</subject><subject>Lesions</subject><subject>Male</subject><subject>Neoplasms - complications</subject><subject>Neoplasms - immunology</subject><subject>Organ Transplantation - adverse effects</subject><subject>Simplexvirus</subject><subject>Transplantation</subject><subject>Viremia</subject><subject>Viremia - complications</subject><subject>Viremia - drug therapy</subject><subject>Viremia - etiology</subject><subject>Viruses</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtv1DAUha0K1Ja2exZFyopdpr7xmx0aFQZpxKsPEBvLSa5bl2QSbA-Uf0-mM5otq3uk7zt3cQh5CXQG1LCLpgur0KYL0DM24xQOyDEIpkopDDybMhW65JrpI_IipQdKATQVh-RQb1LFjsn1AuOIqbgK_djhY3EbIvbBvSm-4jjEXAy-uAx397n4jG1wOYammLs0FdyqnZzfAf9snHyPxTJkjC6vI56S5951Cc9294TcvLu8ni_K5af3H-Zvl2XDOEApfUU5aqh0Q7lSjCluKl5zyRtVc4-e-pp67VDU2iO0xnjphDHccWmkMeyEvN7-HePwa40p2z6kBrvOrXBYJ6ukEEAr_V8RpAQuhJxEuhWbOKQU0dsxht7Fvxao3Sxud4tb0JbZafGp8mr3e1332O4Lu4knfr7lDykPcY85F0o91cstDinj4x67-NNKxZSwi-8_7O2XjxUsr4z9xv4Bxd2VHw</recordid><startdate>199403</startdate><enddate>199403</enddate><creator>Stanberry, Lawrence R.</creator><creator>Floyd-Reising, Shirley A.</creator><creator>Connelly, Beverly L.</creator><creator>Alter, Sherman J.</creator><creator>Gilchrist, Mary J. R.</creator><creator>Rubio, Casilda</creator><creator>Myers, Martin G.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199403</creationdate><title>Herpes Simplex Viremia: Report of Eight Pediatric Cases and Review of the Literature</title><author>Stanberry, Lawrence R. ; Floyd-Reising, Shirley A. ; Connelly, Beverly L. ; Alter, Sherman J. ; Gilchrist, Mary J. R. ; Rubio, Casilda ; Myers, Martin G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3411-6f204e8128c04773374924b464c7b4fef0fb0f8ae5b8fe1d99f6a5994a4696993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Antiviral Agents - therapeutic use</topic><topic>Blood</topic><topic>Child, Preschool</topic><topic>Clinical Infectious Disease Articles</topic><topic>Female</topic><topic>Fever</topic><topic>Hepatitis</topic><topic>Herpes simplex</topic><topic>Herpes Simplex - complications</topic><topic>Herpes Simplex - drug therapy</topic><topic>Herpes Simplex - etiology</topic><topic>herpes simplex virus</topic><topic>Humans</topic><topic>Immunocompromised Host</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infections</topic><topic>Lesions</topic><topic>Male</topic><topic>Neoplasms - complications</topic><topic>Neoplasms - immunology</topic><topic>Organ Transplantation - adverse effects</topic><topic>Simplexvirus</topic><topic>Transplantation</topic><topic>Viremia</topic><topic>Viremia - complications</topic><topic>Viremia - drug therapy</topic><topic>Viremia - etiology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stanberry, Lawrence R.</creatorcontrib><creatorcontrib>Floyd-Reising, Shirley A.</creatorcontrib><creatorcontrib>Connelly, Beverly L.</creatorcontrib><creatorcontrib>Alter, Sherman J.</creatorcontrib><creatorcontrib>Gilchrist, Mary J. 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Blood was cultured for HSV because of perinatal exposure, for routine surveillance, or for the evaluation of fever, esophagitis, or oral lesions in immunocompromised patients. In five cases HSV was recovered only from the blood; in two other instances blood cultures for HSV were the first positive cultures. The time required for the detection of HSV by blood culture ranged from 1 day to 12 days. In one case viremia was transient and cleared without specific therapy. The other seven cases were treated with intravenous acyclovir; in four of these cases, therapy was initiated because of the positive blood culture. The detection of HSV in blood may promote early initiation of antiviral therapy and thereby improve prognosis.</abstract><cop>United States</cop><pub>The University of Chicago Press</pub><pmid>8011823</pmid><doi>10.1093/clinids/18.3.401</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Clinical infectious diseases, 1994-03, Vol.18 (3), p.401-407 |
| issn | 1058-4838 1537-6591 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy; JSTOR Archive Collection A-Z Listing |
| subjects | Antiviral Agents - therapeutic use Blood Child, Preschool Clinical Infectious Disease Articles Female Fever Hepatitis Herpes simplex Herpes Simplex - complications Herpes Simplex - drug therapy Herpes Simplex - etiology herpes simplex virus Humans Immunocompromised Host Infant Infant, Newborn Infections Lesions Male Neoplasms - complications Neoplasms - immunology Organ Transplantation - adverse effects Simplexvirus Transplantation Viremia Viremia - complications Viremia - drug therapy Viremia - etiology Viruses |
| title | Herpes Simplex Viremia: Report of Eight Pediatric Cases and Review of the Literature |
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