Detection of visna virus antigens and RNA in glial cells in foci of demyelination
Visna is a slow virus infection of sheep in which the characteristic pathological change is demyelination in foci of inflammation. The latter is thought to be the result of an immunopathological process directed against cellular and antigenic targets that have been difficult to define because of res...
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| Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 1985-01, Vol.141 (2), p.311-318 |
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| container_title | Virology (New York, N.Y.) |
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| creator | STOWRING, L HAASE, A. T PETURSSON, G GEORGSSON, G PALSSON, P LUTLEY, R ROOS, R SZUCHET, S |
| description | Visna is a slow virus infection of sheep in which the characteristic pathological change is demyelination in foci of inflammation. The latter is thought to be the result of an immunopathological process directed against cellular and antigenic targets that have been difficult to define because of restricted viral gene expression. A new simultaneous detection assay is used to demonstrate viral RNA in cells identified unambiguously as oligodendrocytes and astrocytes. These cells were found in inflammatory foci. With a new strain of virus that causes a rapid form of visna in Icelandic sheep, viral antigens were demonstrated in cells in the inflammatory lesions. These findings are consistent with the postulated immunopathological mechanism of demyelination: cells that maintain intact myelin sheaths in the central nervous system are destroyed by the inflammatory response to viral antigens expressed in these cells. |
| doi_str_mv | 10.1016/0042-6822(85)90264-8 |
| format | Article |
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These findings are consistent with the postulated immunopathological mechanism of demyelination: cells that maintain intact myelin sheaths in the central nervous system are destroyed by the inflammatory response to viral antigens expressed in these cells.</description><identifier>ISSN: 0042-6822</identifier><identifier>EISSN: 1096-0341</identifier><identifier>DOI: 10.1016/0042-6822(85)90264-8</identifier><identifier>PMID: 3002020</identifier><identifier>CODEN: VIRLAX</identifier><language>eng</language><publisher>San Diego, CA: Elsevier</publisher><subject>Animals ; Antigens, Viral - analysis ; Astrocytes - immunology ; Astrocytes - microbiology ; Biological and medical sciences ; Demyelinating Diseases - immunology ; Demyelinating Diseases - microbiology ; Fundamental and applied biological sciences. Psychology ; Microbiology ; Morphology, structure, chemical composition, physicochemical properties ; Neuroglia - immunology ; Neuroglia - microbiology ; Nucleic Acid Hybridization ; Oligodendroglia - immunology ; Oligodendroglia - microbiology ; Retroviridae Infections - immunology ; Retroviridae Infections - microbiology ; RNA, Viral - analysis ; Sheep ; Virology ; visna virus ; Visna-maedi virus - genetics ; Visna-maedi virus - immunology</subject><ispartof>Virology (New York, N.Y.), 1985-01, Vol.141 (2), p.311-318</ispartof><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8420202$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3002020$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>STOWRING, L</creatorcontrib><creatorcontrib>HAASE, A. 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With a new strain of virus that causes a rapid form of visna in Icelandic sheep, viral antigens were demonstrated in cells in the inflammatory lesions. These findings are consistent with the postulated immunopathological mechanism of demyelination: cells that maintain intact myelin sheaths in the central nervous system are destroyed by the inflammatory response to viral antigens expressed in these cells.</description><subject>Animals</subject><subject>Antigens, Viral - analysis</subject><subject>Astrocytes - immunology</subject><subject>Astrocytes - microbiology</subject><subject>Biological and medical sciences</subject><subject>Demyelinating Diseases - immunology</subject><subject>Demyelinating Diseases - microbiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Microbiology</subject><subject>Morphology, structure, chemical composition, physicochemical properties</subject><subject>Neuroglia - immunology</subject><subject>Neuroglia - microbiology</subject><subject>Nucleic Acid Hybridization</subject><subject>Oligodendroglia - immunology</subject><subject>Oligodendroglia - microbiology</subject><subject>Retroviridae Infections - immunology</subject><subject>Retroviridae Infections - microbiology</subject><subject>RNA, Viral - analysis</subject><subject>Sheep</subject><subject>Virology</subject><subject>visna virus</subject><subject>Visna-maedi virus - genetics</subject><subject>Visna-maedi virus - immunology</subject><issn>0042-6822</issn><issn>1096-0341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMo67r6DxR6ENFDNZmkSXpc1k9YFEXPJU2nS6RN16YV9t_bYvEqA_PB-8zLMIScMnrNKJM3lAqIpQa41MlVSkGKWO-ROaOpjCkXbJ_M_5BDchTCJx1mpeiMzDilMMScvN5ih7ZzjY-aMvp2wZsht32IjO_cBv3YFNHb8zJyPtpUzlSRxaoK41g21o1rBdY7rJw3o88xOShNFfBkqgvycX_3vnqM1y8PT6vlOvYAqostqFylKaIFLKQFmmumOHKW8FKkwBFpKXSScy0lWMaEEgVwliYc8pInii_Ixa_vtm2-egxdVrswnmY8Nn3IlEwSOvL_gUxwAE71AJ5NYJ_XWGTb1tWm3WXTswb9fNJNsKYqW-OtC3-YFiMF_Af3dnav</recordid><startdate>19850101</startdate><enddate>19850101</enddate><creator>STOWRING, L</creator><creator>HAASE, A. 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T ; PETURSSON, G ; GEORGSSON, G ; PALSSON, P ; LUTLEY, R ; ROOS, R ; SZUCHET, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-n227t-c27b799eec2ed6c20b8173e3153f4923ee0f485b38662c11474d2319532bf3573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Antigens, Viral - analysis</topic><topic>Astrocytes - immunology</topic><topic>Astrocytes - microbiology</topic><topic>Biological and medical sciences</topic><topic>Demyelinating Diseases - immunology</topic><topic>Demyelinating Diseases - microbiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Microbiology</topic><topic>Morphology, structure, chemical composition, physicochemical properties</topic><topic>Neuroglia - immunology</topic><topic>Neuroglia - microbiology</topic><topic>Nucleic Acid Hybridization</topic><topic>Oligodendroglia - immunology</topic><topic>Oligodendroglia - microbiology</topic><topic>Retroviridae Infections - immunology</topic><topic>Retroviridae Infections - microbiology</topic><topic>RNA, Viral - analysis</topic><topic>Sheep</topic><topic>Virology</topic><topic>visna virus</topic><topic>Visna-maedi virus - genetics</topic><topic>Visna-maedi virus - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>STOWRING, L</creatorcontrib><creatorcontrib>HAASE, A. 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A new simultaneous detection assay is used to demonstrate viral RNA in cells identified unambiguously as oligodendrocytes and astrocytes. These cells were found in inflammatory foci. With a new strain of virus that causes a rapid form of visna in Icelandic sheep, viral antigens were demonstrated in cells in the inflammatory lesions. These findings are consistent with the postulated immunopathological mechanism of demyelination: cells that maintain intact myelin sheaths in the central nervous system are destroyed by the inflammatory response to viral antigens expressed in these cells.</abstract><cop>San Diego, CA</cop><pub>Elsevier</pub><pmid>3002020</pmid><doi>10.1016/0042-6822(85)90264-8</doi><tpages>8</tpages></addata></record> |
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| ispartof | Virology (New York, N.Y.), 1985-01, Vol.141 (2), p.311-318 |
| issn | 0042-6822 1096-0341 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Antigens, Viral - analysis Astrocytes - immunology Astrocytes - microbiology Biological and medical sciences Demyelinating Diseases - immunology Demyelinating Diseases - microbiology Fundamental and applied biological sciences. Psychology Microbiology Morphology, structure, chemical composition, physicochemical properties Neuroglia - immunology Neuroglia - microbiology Nucleic Acid Hybridization Oligodendroglia - immunology Oligodendroglia - microbiology Retroviridae Infections - immunology Retroviridae Infections - microbiology RNA, Viral - analysis Sheep Virology visna virus Visna-maedi virus - genetics Visna-maedi virus - immunology |
| title | Detection of visna virus antigens and RNA in glial cells in foci of demyelination |
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