Calcium-dependence of somatostatin binding to receptors
Binding of 125I-[Tyr 11] somatostatin (S14) and 125I-[Tyr 1]S14 has been studied in pancreatic acini and cerebral cortex. Ca 2+-dependence of somatostatin binding to receptors was observed only with the highly non degradable iodinated analog 125I-[Tyr 11] somatostatin but not with 125I-[Tyr 1] somat...
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| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1985-09, Vol.6 (5), p.831-833 |
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| container_title | Peptides (New York, N.Y. : 1980) |
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| creator | Susini, C.H. Esteve, J.P. Vaysse, N. Ribet, A. |
| description | Binding of
125I-[Tyr
11] somatostatin (S14) and
125I-[Tyr
1]S14 has been studied in pancreatic acini and cerebral cortex. Ca
2+-dependence of somatostatin binding to receptors was observed only with the highly non degradable iodinated analog
125I-[Tyr
11] somatostatin but not with
125I-[Tyr
1] somatostatin. The inhibitory activity of S14 on secretin-stimulated cAMP cellular content was decreased when Ca
2+ concentration in the medium was reduced to 30 nM, indicating that the Ca
2+ dependence of somatostatin binding to receptors is also present with the native peptide. |
| doi_str_mv | 10.1016/0196-9781(85)90309-2 |
| format | Article |
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125I-[Tyr
11] somatostatin (S14) and
125I-[Tyr
1]S14 has been studied in pancreatic acini and cerebral cortex. Ca
2+-dependence of somatostatin binding to receptors was observed only with the highly non degradable iodinated analog
125I-[Tyr
11] somatostatin but not with
125I-[Tyr
1] somatostatin. The inhibitory activity of S14 on secretin-stimulated cAMP cellular content was decreased when Ca
2+ concentration in the medium was reduced to 30 nM, indicating that the Ca
2+ dependence of somatostatin binding to receptors is also present with the native peptide.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/0196-9781(85)90309-2</identifier><identifier>PMID: 2867524</identifier><identifier>CODEN: PPTDD5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Calcium - physiology ; Cell receptors ; Cell structures and functions ; Cerebral Cortex - metabolism ; Cerebro-cortical membranes ; Cyclic AMP ; Cyclic AMP - metabolism ; Fundamental and applied biological sciences. Psychology ; Guinea Pigs ; In Vitro Techniques ; Iodine Radioisotopes ; Molecular and cellular biology ; Pancreas - metabolism ; Pancreatic membranes ; Receptors, Cell Surface - metabolism ; Receptors, Somatostatin ; Somatostatin - metabolism ; Somatostatin receptors</subject><ispartof>Peptides (New York, N.Y. : 1980), 1985-09, Vol.6 (5), p.831-833</ispartof><rights>1985</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-c4f7bfebde6a51bb0c2d0c5e91e5a4274d141ab3438ab659eaab1a668b9da59e3</citedby><cites>FETCH-LOGICAL-c386t-c4f7bfebde6a51bb0c2d0c5e91e5a4274d141ab3438ab659eaab1a668b9da59e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0196-9781(85)90309-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8832055$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2867524$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Susini, C.H.</creatorcontrib><creatorcontrib>Esteve, J.P.</creatorcontrib><creatorcontrib>Vaysse, N.</creatorcontrib><creatorcontrib>Ribet, A.</creatorcontrib><title>Calcium-dependence of somatostatin binding to receptors</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>Binding of
125I-[Tyr
11] somatostatin (S14) and
125I-[Tyr
1]S14 has been studied in pancreatic acini and cerebral cortex. Ca
2+-dependence of somatostatin binding to receptors was observed only with the highly non degradable iodinated analog
125I-[Tyr
11] somatostatin but not with
125I-[Tyr
1] somatostatin. The inhibitory activity of S14 on secretin-stimulated cAMP cellular content was decreased when Ca
2+ concentration in the medium was reduced to 30 nM, indicating that the Ca
2+ dependence of somatostatin binding to receptors is also present with the native peptide.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcium - physiology</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>Cerebral Cortex - metabolism</subject><subject>Cerebro-cortical membranes</subject><subject>Cyclic AMP</subject><subject>Cyclic AMP - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Guinea Pigs</subject><subject>In Vitro Techniques</subject><subject>Iodine Radioisotopes</subject><subject>Molecular and cellular biology</subject><subject>Pancreas - metabolism</subject><subject>Pancreatic membranes</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Receptors, Somatostatin</subject><subject>Somatostatin - metabolism</subject><subject>Somatostatin receptors</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMoun78A4UeRPRQTdokTS6CLH6B4EXPYZJMJdI2a9IV_Pd23WWPnoZhnvdleAg5ZfSaUSZvKNOy1I1il0pcaVpTXVY7ZMZUU5eCSb1LZlvkgBzm_Ekp5VyrfbJfKdmIis9IM4fOhWVfelzg4HFwWMS2yLGHMeYRxjAUNgw-DB_FGIuEDhdjTPmY7LXQZTzZzCPy_nD_Nn8qX14fn-d3L6WrlRxLx9vGtmg9ShDMWuoqT51AzVAArxruGWdga14rsFJoBLAMpFRWe5jW-ohcrHsXKX4tMY-mD9lh18GAcZlNIwWvpVATyNegSzHnhK1ZpNBD-jGMmpUvs5JhVjKMEubPl6mm2Nmmf2l79NvQRtB0P9_cITvo2gSDC3mLKVVXVIgJu11jOLn4DphMdmEl04dJ2Wh8DP__8Qs7Goc1</recordid><startdate>198509</startdate><enddate>198509</enddate><creator>Susini, C.H.</creator><creator>Esteve, J.P.</creator><creator>Vaysse, N.</creator><creator>Ribet, A.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198509</creationdate><title>Calcium-dependence of somatostatin binding to receptors</title><author>Susini, C.H. ; Esteve, J.P. ; Vaysse, N. ; Ribet, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-c4f7bfebde6a51bb0c2d0c5e91e5a4274d141ab3438ab659eaab1a668b9da59e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcium - physiology</topic><topic>Cell receptors</topic><topic>Cell structures and functions</topic><topic>Cerebral Cortex - metabolism</topic><topic>Cerebro-cortical membranes</topic><topic>Cyclic AMP</topic><topic>Cyclic AMP - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Guinea Pigs</topic><topic>In Vitro Techniques</topic><topic>Iodine Radioisotopes</topic><topic>Molecular and cellular biology</topic><topic>Pancreas - metabolism</topic><topic>Pancreatic membranes</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Receptors, Somatostatin</topic><topic>Somatostatin - metabolism</topic><topic>Somatostatin receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Susini, C.H.</creatorcontrib><creatorcontrib>Esteve, J.P.</creatorcontrib><creatorcontrib>Vaysse, N.</creatorcontrib><creatorcontrib>Ribet, A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Susini, C.H.</au><au>Esteve, J.P.</au><au>Vaysse, N.</au><au>Ribet, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Calcium-dependence of somatostatin binding to receptors</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>1985-09</date><risdate>1985</risdate><volume>6</volume><issue>5</issue><spage>831</spage><epage>833</epage><pages>831-833</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><coden>PPTDD5</coden><abstract>Binding of
125I-[Tyr
11] somatostatin (S14) and
125I-[Tyr
1]S14 has been studied in pancreatic acini and cerebral cortex. Ca
2+-dependence of somatostatin binding to receptors was observed only with the highly non degradable iodinated analog
125I-[Tyr
11] somatostatin but not with
125I-[Tyr
1] somatostatin. The inhibitory activity of S14 on secretin-stimulated cAMP cellular content was decreased when Ca
2+ concentration in the medium was reduced to 30 nM, indicating that the Ca
2+ dependence of somatostatin binding to receptors is also present with the native peptide.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2867524</pmid><doi>10.1016/0196-9781(85)90309-2</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0196-9781 |
| ispartof | Peptides (New York, N.Y. : 1980), 1985-09, Vol.6 (5), p.831-833 |
| issn | 0196-9781 1873-5169 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76543658 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Calcium - physiology Cell receptors Cell structures and functions Cerebral Cortex - metabolism Cerebro-cortical membranes Cyclic AMP Cyclic AMP - metabolism Fundamental and applied biological sciences. Psychology Guinea Pigs In Vitro Techniques Iodine Radioisotopes Molecular and cellular biology Pancreas - metabolism Pancreatic membranes Receptors, Cell Surface - metabolism Receptors, Somatostatin Somatostatin - metabolism Somatostatin receptors |
| title | Calcium-dependence of somatostatin binding to receptors |
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