Comparative Evaluation of Aztreonam in Therapy for Experimental Bacterial Meningitis and Cerebritis

Aztreonam (SQ 26,776), a new monocyclic β-lactam agent, was compared with several frequently used antibiotics in therapy for three types of experimental meningitis in rabbits and for experimental Escherichia coli cerebritis in rats. Aztreonam was highly active against common gram-negative meningeal...

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Veröffentlicht in:	Reviews of infectious diseases 1985-11, Vol.7, p.S635-S647
Hauptverfasser:	Scheld, W. Michael, James P. Brodeur, Pamela A. Foresman, Jean C. Gratz, George T. Rodeheaver
Format:	Artikel
Sprache:	eng
Schlagworte:	Ampicillin - therapeutic use Animals Antibiotics Aztreonam - metabolism Aztreonam - therapeutic use Bacterial meningitis Brain - metabolism Brain abscess Brain Abscess - drug therapy Cerebral hemispheres Drug Evaluation, Preclinical Encephalitis - drug therapy Encephalitis - metabolism Escherichia coli Infections - drug therapy Escherichia coli meningitis Female Gentamicins - therapeutic use Haemophilus influenzae Haemophilus meningitis Inoculation Listeria meningitis Meningitis - drug therapy Meningitis - metabolism Meningitis, Haemophilus - drug therapy Meningitis, Haemophilus - metabolism Meningococcal meningitis Penicillin Resistance Rabbits Rats Rats, Inbred Strains Session II: Discovery, Development, and Properties of Attreonam
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