Analysis of HPV16 E6 and mutant p53-transfected keratinocytes in reconstituted epidermis suggests that wild-type p53 inhibits cytokeratin 19 expression

Using a reconstituted skin culture model we have analysed the effects of oncogenic human papillomavirus (HPV) and mutant TP53 genes on the proliferation and differentiation of human keratinocytes. Immortal cell lines generated by transfection of early passage normal human keratinocytes with HPV16 E7...

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Veröffentlicht in:	Journal of cell science 1994-02, Vol.107 (2), p.435-441
Hauptverfasser:	MOLES, J.-P, SCHILLER, J. T, TESNIERE, A, LEIGH, I. M, GUILHOU, J.-J, BASSET-SEGUIN, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Differentiation Cell Division Cell Line Culture Techniques Fundamental and applied biological sciences. Psychology Gene Expression Genes, p53 Genes, Viral Humans Keratinocytes - metabolism Keratins - genetics Mutation Oncogene Proteins, Viral - genetics Papillomaviridae - genetics Papillomavirus E7 Proteins Phenotype Repressor Proteins Skin - cytology Skin - metabolism Skin Neoplasms - genetics Skin Neoplasms - pathology Transfection Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue
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