Lithium sustains the acute antidepressant effects of sleep deprivation: Preliminary findings from a controlled study
Early morning sleep deprivation (patient awake from 0200 to 2200 hours) produces a same-day antidepressant effect in approximately one-half of patients with major depression. Unfortunately, these antidepressant effects are short-lived and patients usually relapse to baseline depression levels within...
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| Veröffentlicht in: | Psychiatry research 1994-03, Vol.51 (3), p.283-295 |
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| container_title | Psychiatry research |
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| creator | Szuba, Martin P. Baxter, Lewis R. Altshuler, Lori L. Allen, Eva M. Guze, Barry H. Schwartz, Jeffrey M. Liston, Edward H. |
| description | Early morning sleep deprivation (patient awake from 0200 to 2200 hours) produces a same-day antidepressant effect in approximately one-half of patients with major depression. Unfortunately, these antidepressant effects are short-lived and patients usually relapse to baseline depression levels within 48 hours. Recent work suggests, however, that the use of lithium with early morning sleep deprivation sustains this rapid antidepressant effect and makes it clinically useful. In a 30-day study, we compared the abilities of four different treatments (lithium plus early morning sleep deprivation, lithium plus a control sleep deprivation procedure, and desipramine with either of the two sleep manipulations) to induce a rapid (next-day) and sustained antidepressant response in 16 depressed patients. Lithium plus early morning sleep deprivation produced a quicker response than lithium with the control sleep deprivation, and the response was sustained for at least 30 days. In this design, however, lithium/early morning sleep deprivation was no faster than either of the two desipramine / sleep deprivation conditions in inducing remission. These results support the results of previous studies and suggest further investigation of this novel sleep/ pharmacologic intervention is warranted. |
| doi_str_mv | 10.1016/0165-1781(94)90015-9 |
| format | Article |
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Unfortunately, these antidepressant effects are short-lived and patients usually relapse to baseline depression levels within 48 hours. Recent work suggests, however, that the use of lithium with early morning sleep deprivation sustains this rapid antidepressant effect and makes it clinically useful. In a 30-day study, we compared the abilities of four different treatments (lithium plus early morning sleep deprivation, lithium plus a control sleep deprivation procedure, and desipramine with either of the two sleep manipulations) to induce a rapid (next-day) and sustained antidepressant response in 16 depressed patients. Lithium plus early morning sleep deprivation produced a quicker response than lithium with the control sleep deprivation, and the response was sustained for at least 30 days. In this design, however, lithium/early morning sleep deprivation was no faster than either of the two desipramine / sleep deprivation conditions in inducing remission. These results support the results of previous studies and suggest further investigation of this novel sleep/ pharmacologic intervention is warranted.</description><identifier>ISSN: 0165-1781</identifier><identifier>EISSN: 1872-7123</identifier><identifier>DOI: 10.1016/0165-1781(94)90015-9</identifier><identifier>PMID: 8208874</identifier><identifier>CODEN: PSRSDR</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Affective disorder ; Analysis of Variance ; Associated treatments ; Biological and medical sciences ; bipolar depression ; Combined Modality Therapy ; Depressive Disorder - physiopathology ; Depressive Disorder - psychology ; Depressive Disorder - therapy ; desipramine ; Female ; Humans ; Lithium - therapeutic use ; Male ; Medical sciences ; Middle Aged ; Psychiatric Status Rating Scales ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Sleep Deprivation - physiology ; Time Factors ; Treatments ; unipolar depression</subject><ispartof>Psychiatry research, 1994-03, Vol.51 (3), p.283-295</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-50b27e6ebb8429e4d18b407619d43121063d4e3dd68a8782dcbd73ced06ff2c13</citedby><cites>FETCH-LOGICAL-c498t-50b27e6ebb8429e4d18b407619d43121063d4e3dd68a8782dcbd73ced06ff2c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0165-1781(94)90015-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3977149$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8208874$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Szuba, Martin P.</creatorcontrib><creatorcontrib>Baxter, Lewis R.</creatorcontrib><creatorcontrib>Altshuler, Lori L.</creatorcontrib><creatorcontrib>Allen, Eva M.</creatorcontrib><creatorcontrib>Guze, Barry H.</creatorcontrib><creatorcontrib>Schwartz, Jeffrey M.</creatorcontrib><creatorcontrib>Liston, Edward H.</creatorcontrib><title>Lithium sustains the acute antidepressant effects of sleep deprivation: Preliminary findings from a controlled study</title><title>Psychiatry research</title><addtitle>Psychiatry Res</addtitle><description>Early morning sleep deprivation (patient awake from 0200 to 2200 hours) produces a same-day antidepressant effect in approximately one-half of patients with major depression. Unfortunately, these antidepressant effects are short-lived and patients usually relapse to baseline depression levels within 48 hours. Recent work suggests, however, that the use of lithium with early morning sleep deprivation sustains this rapid antidepressant effect and makes it clinically useful. In a 30-day study, we compared the abilities of four different treatments (lithium plus early morning sleep deprivation, lithium plus a control sleep deprivation procedure, and desipramine with either of the two sleep manipulations) to induce a rapid (next-day) and sustained antidepressant response in 16 depressed patients. Lithium plus early morning sleep deprivation produced a quicker response than lithium with the control sleep deprivation, and the response was sustained for at least 30 days. In this design, however, lithium/early morning sleep deprivation was no faster than either of the two desipramine / sleep deprivation conditions in inducing remission. These results support the results of previous studies and suggest further investigation of this novel sleep/ pharmacologic intervention is warranted.</description><subject>Adult</subject><subject>Affective disorder</subject><subject>Analysis of Variance</subject><subject>Associated treatments</subject><subject>Biological and medical sciences</subject><subject>bipolar depression</subject><subject>Combined Modality Therapy</subject><subject>Depressive Disorder - physiopathology</subject><subject>Depressive Disorder - psychology</subject><subject>Depressive Disorder - therapy</subject><subject>desipramine</subject><subject>Female</subject><subject>Humans</subject><subject>Lithium - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Sleep Deprivation - physiology</subject><subject>Time Factors</subject><subject>Treatments</subject><subject>unipolar depression</subject><issn>0165-1781</issn><issn>1872-7123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9rFTEUxYMo9bX1GyhkIaKL0WQmb5J0IUipVXigi7oOmeTGRmYyz9xMod_ejO_xll3kD5xzD_f8CHnN2UfOeP-pnm3DpeLvtfigGePbRj8jG65k20jeds_J5mR5Sc4R_zDGWq71GTlTLVNKig0pu1ju4zJRXLDYmJCWe6DWLaXeqUQP-wyI9UshBHAF6RwojgB7umrxwZY4pyv6M8MYp5hsfqQhJh_Tb6QhzxO11M2p5HkcwVMsi3-8JC-CHRFeHd8L8uvrzd31t2b34_b79Zdd44RWpdmyoZXQwzAo0WoQnqtBMNlz7UXHW876zgvovO-VVVK13g1edg4860NoHe8uyLtD7j7PfxfAYqaIDsbRJpgXNLLfdroTq1EcjC7PiBmCqc2mWsVwZlbYZiVpVpJGC_MfttF17M0xfxkm8KehI92qvz3qFp0dQ7bJRTzZOi0lF2vM54MNKouHCNmgi5BqkZgrcePn-PQe_wCeyJ08</recordid><startdate>19940301</startdate><enddate>19940301</enddate><creator>Szuba, Martin P.</creator><creator>Baxter, Lewis R.</creator><creator>Altshuler, Lori L.</creator><creator>Allen, Eva M.</creator><creator>Guze, Barry H.</creator><creator>Schwartz, Jeffrey M.</creator><creator>Liston, Edward H.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940301</creationdate><title>Lithium sustains the acute antidepressant effects of sleep deprivation: Preliminary findings from a controlled study</title><author>Szuba, Martin P. ; Baxter, Lewis R. ; Altshuler, Lori L. ; Allen, Eva M. ; Guze, Barry H. ; Schwartz, Jeffrey M. ; Liston, Edward H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-50b27e6ebb8429e4d18b407619d43121063d4e3dd68a8782dcbd73ced06ff2c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adult</topic><topic>Affective disorder</topic><topic>Analysis of Variance</topic><topic>Associated treatments</topic><topic>Biological and medical sciences</topic><topic>bipolar depression</topic><topic>Combined Modality Therapy</topic><topic>Depressive Disorder - physiopathology</topic><topic>Depressive Disorder - psychology</topic><topic>Depressive Disorder - therapy</topic><topic>desipramine</topic><topic>Female</topic><topic>Humans</topic><topic>Lithium - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Sleep Deprivation - physiology</topic><topic>Time Factors</topic><topic>Treatments</topic><topic>unipolar depression</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Szuba, Martin P.</creatorcontrib><creatorcontrib>Baxter, Lewis R.</creatorcontrib><creatorcontrib>Altshuler, Lori L.</creatorcontrib><creatorcontrib>Allen, Eva M.</creatorcontrib><creatorcontrib>Guze, Barry H.</creatorcontrib><creatorcontrib>Schwartz, Jeffrey M.</creatorcontrib><creatorcontrib>Liston, Edward H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Szuba, Martin P.</au><au>Baxter, Lewis R.</au><au>Altshuler, Lori L.</au><au>Allen, Eva M.</au><au>Guze, Barry H.</au><au>Schwartz, Jeffrey M.</au><au>Liston, Edward H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lithium sustains the acute antidepressant effects of sleep deprivation: Preliminary findings from a controlled study</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>1994-03-01</date><risdate>1994</risdate><volume>51</volume><issue>3</issue><spage>283</spage><epage>295</epage><pages>283-295</pages><issn>0165-1781</issn><eissn>1872-7123</eissn><coden>PSRSDR</coden><abstract>Early morning sleep deprivation (patient awake from 0200 to 2200 hours) produces a same-day antidepressant effect in approximately one-half of patients with major depression. Unfortunately, these antidepressant effects are short-lived and patients usually relapse to baseline depression levels within 48 hours. Recent work suggests, however, that the use of lithium with early morning sleep deprivation sustains this rapid antidepressant effect and makes it clinically useful. In a 30-day study, we compared the abilities of four different treatments (lithium plus early morning sleep deprivation, lithium plus a control sleep deprivation procedure, and desipramine with either of the two sleep manipulations) to induce a rapid (next-day) and sustained antidepressant response in 16 depressed patients. Lithium plus early morning sleep deprivation produced a quicker response than lithium with the control sleep deprivation, and the response was sustained for at least 30 days. In this design, however, lithium/early morning sleep deprivation was no faster than either of the two desipramine / sleep deprivation conditions in inducing remission. These results support the results of previous studies and suggest further investigation of this novel sleep/ pharmacologic intervention is warranted.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>8208874</pmid><doi>10.1016/0165-1781(94)90015-9</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Psychiatry research, 1994-03, Vol.51 (3), p.283-295 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Affective disorder Analysis of Variance Associated treatments Biological and medical sciences bipolar depression Combined Modality Therapy Depressive Disorder - physiopathology Depressive Disorder - psychology Depressive Disorder - therapy desipramine Female Humans Lithium - therapeutic use Male Medical sciences Middle Aged Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Sleep Deprivation - physiology Time Factors Treatments unipolar depression |
| title | Lithium sustains the acute antidepressant effects of sleep deprivation: Preliminary findings from a controlled study |
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