Evolutional changes of cortical hypometabolism in West's syndrome
Summary The pathophysiological basis of the epileptic encephalopathy West's syndrome remains unknown. We have done serial positron emission tomography (PET) with fluorine-18-labelled 2-deoxy-3-fluoro-D-glucose (FDG) in twelve patients with newly diagnosed West's syndrome. Throughout follow...
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| Veröffentlicht in: | The Lancet (British edition) 1994-06, Vol.343 (8913), p.1620-1623 |
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| creator | Maeda, N. Watanabe, K. Negoro, T. Aso, K. Ohki, T. lto, K. Kato, T. |
| description | Summary
The pathophysiological basis of the epileptic encephalopathy West's syndrome remains unknown. We have done serial positron emission tomography (PET) with fluorine-18-labelled 2-deoxy-3-fluoro-D-glucose (FDG) in twelve patients with newly diagnosed West's syndrome.
Throughout follow-up, PET revealed diffuse or focal cortical hypometabolism in eleven patients, whereas magnetic resonance imaging (MRI) showed morphological abnormalities in only five. At disease onset, PET showed cortical hypometabolism in eight patients (diffuse in three, focal in five). The second PET showed normal metabolism in six of these patients but focal abnormalities in three of the four with normal results on first PET. In all seven patients with normal findings on the second PET, tonic spasms ceased after initial treatment and no epileptic seizure occurred thereafter. In the five patients with cortical hypometabolism on the second PET, tonic spasms persisted or recurred, or partial seizures appeared. However, in two patients PET abnormalities disappeared in accordance with the later resolution of epileptic seizures. All patients with normal MRI and second PET results had normal psychomotor development.
Diffuse or focal cortical hypometabolism that cannot be detected by MRI or computed tomography is common in patients with West's syndrome. However, this anomaly is not permanent and changes with clinical symptoms. These functional abnormalities in the cerebral cortex may be associated with the development of West's syndrome. |
| doi_str_mv | 10.1016/S0140-6736(94)93065-1 |
| format | Article |
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The pathophysiological basis of the epileptic encephalopathy West's syndrome remains unknown. We have done serial positron emission tomography (PET) with fluorine-18-labelled 2-deoxy-3-fluoro-D-glucose (FDG) in twelve patients with newly diagnosed West's syndrome.
Throughout follow-up, PET revealed diffuse or focal cortical hypometabolism in eleven patients, whereas magnetic resonance imaging (MRI) showed morphological abnormalities in only five. At disease onset, PET showed cortical hypometabolism in eight patients (diffuse in three, focal in five). The second PET showed normal metabolism in six of these patients but focal abnormalities in three of the four with normal results on first PET. In all seven patients with normal findings on the second PET, tonic spasms ceased after initial treatment and no epileptic seizure occurred thereafter. In the five patients with cortical hypometabolism on the second PET, tonic spasms persisted or recurred, or partial seizures appeared. However, in two patients PET abnormalities disappeared in accordance with the later resolution of epileptic seizures. All patients with normal MRI and second PET results had normal psychomotor development.
Diffuse or focal cortical hypometabolism that cannot be detected by MRI or computed tomography is common in patients with West's syndrome. However, this anomaly is not permanent and changes with clinical symptoms. These functional abnormalities in the cerebral cortex may be associated with the development of West's syndrome.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(94)93065-1</identifier><identifier>PMID: 7911927</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Biological and medical sciences ; Cerebral Cortex - diagnostic imaging ; Cerebral Cortex - metabolism ; Cerebral Cortex - pathology ; Computed tomography ; Deoxyglucose - analogs & derivatives ; Emissions ; Encephalitis ; Female ; Fluorine ; Fluorodeoxyglucose F18 ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Infant ; Magnetic Resonance Imaging ; Male ; Medical research ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurology ; Spasms, Infantile - diagnosis ; Spasms, Infantile - diagnostic imaging ; Spasms, Infantile - metabolism ; Tomography ; Tomography, Emission-Computed</subject><ispartof>The Lancet (British edition), 1994-06, Vol.343 (8913), p.1620-1623</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><rights>Copyright Lancet Ltd. Jun 25, 1994</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-56c7f1d5f776c019f88d562e9f4b1ccb94425071421c5b603bcf363bae78925f3</citedby><cites>FETCH-LOGICAL-c482t-56c7f1d5f776c019f88d562e9f4b1ccb94425071421c5b603bcf363bae78925f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0140673694930651$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4146636$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7911927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maeda, N.</creatorcontrib><creatorcontrib>Watanabe, K.</creatorcontrib><creatorcontrib>Negoro, T.</creatorcontrib><creatorcontrib>Aso, K.</creatorcontrib><creatorcontrib>Ohki, T.</creatorcontrib><creatorcontrib>lto, K.</creatorcontrib><creatorcontrib>Kato, T.</creatorcontrib><title>Evolutional changes of cortical hypometabolism in West's syndrome</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>Summary
The pathophysiological basis of the epileptic encephalopathy West's syndrome remains unknown. We have done serial positron emission tomography (PET) with fluorine-18-labelled 2-deoxy-3-fluoro-D-glucose (FDG) in twelve patients with newly diagnosed West's syndrome.
Throughout follow-up, PET revealed diffuse or focal cortical hypometabolism in eleven patients, whereas magnetic resonance imaging (MRI) showed morphological abnormalities in only five. At disease onset, PET showed cortical hypometabolism in eight patients (diffuse in three, focal in five). The second PET showed normal metabolism in six of these patients but focal abnormalities in three of the four with normal results on first PET. In all seven patients with normal findings on the second PET, tonic spasms ceased after initial treatment and no epileptic seizure occurred thereafter. In the five patients with cortical hypometabolism on the second PET, tonic spasms persisted or recurred, or partial seizures appeared. However, in two patients PET abnormalities disappeared in accordance with the later resolution of epileptic seizures. All patients with normal MRI and second PET results had normal psychomotor development.
Diffuse or focal cortical hypometabolism that cannot be detected by MRI or computed tomography is common in patients with West's syndrome. However, this anomaly is not permanent and changes with clinical symptoms. These functional abnormalities in the cerebral cortex may be associated with the development of West's syndrome.</description><subject>Biological and medical sciences</subject><subject>Cerebral Cortex - diagnostic imaging</subject><subject>Cerebral Cortex - metabolism</subject><subject>Cerebral Cortex - pathology</subject><subject>Computed tomography</subject><subject>Deoxyglucose - analogs & derivatives</subject><subject>Emissions</subject><subject>Encephalitis</subject><subject>Female</subject><subject>Fluorine</subject><subject>Fluorodeoxyglucose F18</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. 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edition)</jtitle><addtitle>Lancet</addtitle><date>1994-06-25</date><risdate>1994</risdate><volume>343</volume><issue>8913</issue><spage>1620</spage><epage>1623</epage><pages>1620-1623</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>Summary
The pathophysiological basis of the epileptic encephalopathy West's syndrome remains unknown. We have done serial positron emission tomography (PET) with fluorine-18-labelled 2-deoxy-3-fluoro-D-glucose (FDG) in twelve patients with newly diagnosed West's syndrome.
Throughout follow-up, PET revealed diffuse or focal cortical hypometabolism in eleven patients, whereas magnetic resonance imaging (MRI) showed morphological abnormalities in only five. At disease onset, PET showed cortical hypometabolism in eight patients (diffuse in three, focal in five). The second PET showed normal metabolism in six of these patients but focal abnormalities in three of the four with normal results on first PET. In all seven patients with normal findings on the second PET, tonic spasms ceased after initial treatment and no epileptic seizure occurred thereafter. In the five patients with cortical hypometabolism on the second PET, tonic spasms persisted or recurred, or partial seizures appeared. However, in two patients PET abnormalities disappeared in accordance with the later resolution of epileptic seizures. All patients with normal MRI and second PET results had normal psychomotor development.
Diffuse or focal cortical hypometabolism that cannot be detected by MRI or computed tomography is common in patients with West's syndrome. However, this anomaly is not permanent and changes with clinical symptoms. These functional abnormalities in the cerebral cortex may be associated with the development of West's syndrome.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>7911927</pmid><doi>10.1016/S0140-6736(94)93065-1</doi><tpages>4</tpages></addata></record> |
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| subjects | Biological and medical sciences Cerebral Cortex - diagnostic imaging Cerebral Cortex - metabolism Cerebral Cortex - pathology Computed tomography Deoxyglucose - analogs & derivatives Emissions Encephalitis Female Fluorine Fluorodeoxyglucose F18 Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Infant Magnetic Resonance Imaging Male Medical research Medical sciences Nervous system (semeiology, syndromes) Neurology Spasms, Infantile - diagnosis Spasms, Infantile - diagnostic imaging Spasms, Infantile - metabolism Tomography Tomography, Emission-Computed |
| title | Evolutional changes of cortical hypometabolism in West's syndrome |
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