Comparative effect of muramyl dipeptide in vivo and in vitro on the tumoricidal activity of rat peritoneal macrophages

Muramyl dipeptide (MDP) has been tested for its ability to induce rat peritoneal macrophage tumoricidal activity. Rat resident macrophages were activated in vivo and in vitro. Nevertheless, they were cytolytic when harvested 1 or 2 h after an intraperitoneal injection of MDP, but noncytolytic when h...

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Veröffentlicht in:	Journal of biological response modifiers 1985-10, Vol.4 (5), p.460-463
Hauptverfasser:	Reisser, D, Jeannin, J F, Lagadec, P, Martin, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylmuramyl-Alanyl-Isoglutamine - pharmacology Animals Cytotoxicity, Immunologic - drug effects DNA Replication - drug effects In Vitro Techniques Macrophage Activation Macrophages - drug effects Macrophages - immunology Mice Rats Rats, Inbred Strains Species Specificity Time Factors
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creator	Reisser, D Jeannin, J F Lagadec, P Martin, F
description	Muramyl dipeptide (MDP) has been tested for its ability to induce rat peritoneal macrophage tumoricidal activity. Rat resident macrophages were activated in vivo and in vitro. Nevertheless, they were cytolytic when harvested 1 or 2 h after an intraperitoneal injection of MDP, but noncytolytic when harvested later. The activation obtained in vivo and in vitro with small amounts of MDP was not increased with larger doses. As, under the same conditions, mouse peritoneal macrophages were not activated, the sensitivity of the peritoneal macrophages to MDP depends on the species used.
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Rat resident macrophages were activated in vivo and in vitro. Nevertheless, they were cytolytic when harvested 1 or 2 h after an intraperitoneal injection of MDP, but noncytolytic when harvested later. The activation obtained in vivo and in vitro with small amounts of MDP was not increased with larger doses. As, under the same conditions, mouse peritoneal macrophages were not activated, the sensitivity of the peritoneal macrophages to MDP depends on the species used.</description><identifier>ISSN: 0732-6580</identifier><identifier>PMID: 4078593</identifier><language>eng</language><publisher>United States</publisher><subject>Acetylmuramyl-Alanyl-Isoglutamine - pharmacology ; Animals ; Cytotoxicity, Immunologic - drug effects ; DNA Replication - drug effects ; In Vitro Techniques ; Macrophage Activation ; Macrophages - drug effects ; Macrophages - immunology ; Mice ; Rats ; Rats, Inbred Strains ; Species Specificity ; Time Factors</subject><ispartof>Journal of biological response modifiers, 1985-10, Vol.4 (5), p.460-463</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4078593$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reisser, D</creatorcontrib><creatorcontrib>Jeannin, J F</creatorcontrib><creatorcontrib>Lagadec, P</creatorcontrib><creatorcontrib>Martin, F</creatorcontrib><title>Comparative effect of muramyl dipeptide in vivo and in vitro on the tumoricidal activity of rat peritoneal macrophages</title><title>Journal of biological response modifiers</title><addtitle>J Biol Response Mod</addtitle><description>Muramyl dipeptide (MDP) has been tested for its ability to induce rat peritoneal macrophage tumoricidal activity. 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Rat resident macrophages were activated in vivo and in vitro. Nevertheless, they were cytolytic when harvested 1 or 2 h after an intraperitoneal injection of MDP, but noncytolytic when harvested later. The activation obtained in vivo and in vitro with small amounts of MDP was not increased with larger doses. As, under the same conditions, mouse peritoneal macrophages were not activated, the sensitivity of the peritoneal macrophages to MDP depends on the species used.</abstract><cop>United States</cop><pmid>4078593</pmid><tpages>4</tpages></addata></record>
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source	MEDLINE; Journals@Ovid Complete
subjects	Acetylmuramyl-Alanyl-Isoglutamine - pharmacology Animals Cytotoxicity, Immunologic - drug effects DNA Replication - drug effects In Vitro Techniques Macrophage Activation Macrophages - drug effects Macrophages - immunology Mice Rats Rats, Inbred Strains Species Specificity Time Factors
title	Comparative effect of muramyl dipeptide in vivo and in vitro on the tumoricidal activity of rat peritoneal macrophages
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