Effects of Aerosol Ipratropium Bromide on Cardiac Vagal Tone
Thirty-one adult asthmatic subjects, aged 18 to 40 years, were administered both ipratropium bromide and placebo, in two sessions, held at least 2 days apart, in balanced order. Pulmonary function, heart period (milliseconds between heart beats), and respiratory sinus arrhythmia (a measure of cardia...
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| Veröffentlicht in: | Chest 1994-06, Vol.105 (6), p.1701-1704 |
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| container_issue | 6 |
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| container_title | Chest |
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| creator | Lehrer, Paul M. Hochron, Stuart M. Rausch, Lawrence Carr, Richard |
| description | Thirty-one adult asthmatic subjects, aged 18 to 40 years, were administered both ipratropium bromide and placebo, in two sessions, held at least 2 days apart, in balanced order. Pulmonary function, heart period (milliseconds between heart beats), and respiratory sinus arrhythmia (a measure of cardiac vagal tone) were assessed before drug administration and 45 min thereafter. Ipratropium bromide had no significant effect on cardiac vagal tone, while it did produce improvement in pulmonary function. |
| doi_str_mv | 10.1378/chest.105.6.1701 |
| format | Article |
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Pulmonary function, heart period (milliseconds between heart beats), and respiratory sinus arrhythmia (a measure of cardiac vagal tone) were assessed before drug administration and 45 min thereafter. Ipratropium bromide had no significant effect on cardiac vagal tone, while it did produce improvement in pulmonary function.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.105.6.1701</identifier><identifier>PMID: 8205863</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: Elsevier Inc</publisher><subject>Administration, Inhalation ; Adult ; Aerosols ; Asthma - physiopathology ; Biological and medical sciences ; Bronchial Provocation Tests ; Female ; Heart Rate - drug effects ; Humans ; Ipratropium - administration & dosage ; Ipratropium - pharmacology ; Male ; Medical sciences ; Myocardial Contraction - drug effects ; Pharmacology. Drug treatments ; Respiration - drug effects ; Respiratory system ; Spirometry ; Time Factors ; Vagus Nerve - drug effects ; Vagus Nerve - physiology</subject><ispartof>Chest, 1994-06, Vol.105 (6), p.1701-1704</ispartof><rights>1994 The American College of Chest Physicians</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-5e262fa3070684705a8762dab41b8c24c7fa7249771b4e30b83e24dbf60a89f13</citedby><cites>FETCH-LOGICAL-c510t-5e262fa3070684705a8762dab41b8c24c7fa7249771b4e30b83e24dbf60a89f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4126708$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8205863$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lehrer, Paul M.</creatorcontrib><creatorcontrib>Hochron, Stuart M.</creatorcontrib><creatorcontrib>Rausch, Lawrence</creatorcontrib><creatorcontrib>Carr, Richard</creatorcontrib><title>Effects of Aerosol Ipratropium Bromide on Cardiac Vagal Tone</title><title>Chest</title><addtitle>Chest</addtitle><description>Thirty-one adult asthmatic subjects, aged 18 to 40 years, were administered both ipratropium bromide and placebo, in two sessions, held at least 2 days apart, in balanced order. Pulmonary function, heart period (milliseconds between heart beats), and respiratory sinus arrhythmia (a measure of cardiac vagal tone) were assessed before drug administration and 45 min thereafter. Ipratropium bromide had no significant effect on cardiac vagal tone, while it did produce improvement in pulmonary function.</description><subject>Administration, Inhalation</subject><subject>Adult</subject><subject>Aerosols</subject><subject>Asthma - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Bronchial Provocation Tests</subject><subject>Female</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Ipratropium - administration & dosage</subject><subject>Ipratropium - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Myocardial Contraction - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Respiration - drug effects</subject><subject>Respiratory system</subject><subject>Spirometry</subject><subject>Time Factors</subject><subject>Vagus Nerve - drug effects</subject><subject>Vagus Nerve - physiology</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtv1DAQhy0EKkvhzgUpB8Qtix_xI4hLWRWoVIlL4WpNnHHXlRMvdgLiv8dlV0UcOFmj-T08HyEvGd0yoc1bt8eybBmVW7VlmrJHZMN6wVohO_GYbChlvBWq50_Js1LuaJ1Zr87ImeFUGiU25P2l9-iW0iTfXGBOJcXm6pBhyekQ1qn5kNMURmzS3OwgjwFc8w1uITY3acbn5ImHWPDF6T0nXz9e3uw-t9dfPl3tLq5bJxldWolccQ-CaqpMp6kEoxUfYejYYBzvnPageddrzYYOBR2MQN6Ng1cUTO-ZOCdvjrmHnL6v9WI7heIwRpgxrcVqJYXslapCehS6eknJ6O0hhwnyL8uovQdm_wCrk7TK3gOrllen7HWYcHwwnAjV_evTHoqD6DPMLpQHWce40tT8bd6H2_3PkNGWCWKsoeLYeZfWPEP8p_nd0YIV3Y-A2RYXcHY4Vrtb7JjC_7_9GxJOl0I</recordid><startdate>19940601</startdate><enddate>19940601</enddate><creator>Lehrer, Paul M.</creator><creator>Hochron, Stuart M.</creator><creator>Rausch, Lawrence</creator><creator>Carr, Richard</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940601</creationdate><title>Effects of Aerosol Ipratropium Bromide on Cardiac Vagal Tone</title><author>Lehrer, Paul M. ; Hochron, Stuart M. ; Rausch, Lawrence ; Carr, Richard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-5e262fa3070684705a8762dab41b8c24c7fa7249771b4e30b83e24dbf60a89f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Administration, Inhalation</topic><topic>Adult</topic><topic>Aerosols</topic><topic>Asthma - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Bronchial Provocation Tests</topic><topic>Female</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Ipratropium - administration & dosage</topic><topic>Ipratropium - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Myocardial Contraction - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Respiration - drug effects</topic><topic>Respiratory system</topic><topic>Spirometry</topic><topic>Time Factors</topic><topic>Vagus Nerve - drug effects</topic><topic>Vagus Nerve - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lehrer, Paul M.</creatorcontrib><creatorcontrib>Hochron, Stuart M.</creatorcontrib><creatorcontrib>Rausch, Lawrence</creatorcontrib><creatorcontrib>Carr, Richard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lehrer, Paul M.</au><au>Hochron, Stuart M.</au><au>Rausch, Lawrence</au><au>Carr, Richard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Aerosol Ipratropium Bromide on Cardiac Vagal Tone</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1994-06-01</date><risdate>1994</risdate><volume>105</volume><issue>6</issue><spage>1701</spage><epage>1704</epage><pages>1701-1704</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>Thirty-one adult asthmatic subjects, aged 18 to 40 years, were administered both ipratropium bromide and placebo, in two sessions, held at least 2 days apart, in balanced order. Pulmonary function, heart period (milliseconds between heart beats), and respiratory sinus arrhythmia (a measure of cardiac vagal tone) were assessed before drug administration and 45 min thereafter. Ipratropium bromide had no significant effect on cardiac vagal tone, while it did produce improvement in pulmonary function.</abstract><cop>Northbrook, IL</cop><pub>Elsevier Inc</pub><pmid>8205863</pmid><doi>10.1378/chest.105.6.1701</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Chest, 1994-06, Vol.105 (6), p.1701-1704 |
| issn | 0012-3692 1931-3543 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Administration, Inhalation Adult Aerosols Asthma - physiopathology Biological and medical sciences Bronchial Provocation Tests Female Heart Rate - drug effects Humans Ipratropium - administration & dosage Ipratropium - pharmacology Male Medical sciences Myocardial Contraction - drug effects Pharmacology. Drug treatments Respiration - drug effects Respiratory system Spirometry Time Factors Vagus Nerve - drug effects Vagus Nerve - physiology |
| title | Effects of Aerosol Ipratropium Bromide on Cardiac Vagal Tone |
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