Modulation of procainamide's effect on cardiac conduction in dogs by extracellular potassium concentration : a quantitative analysis

Antiarrhythmic drugs are known to have state-dependent interactions with cardiac sodium channels, and these have potentially important implications for drug effects on cardiac conduction, particularly in situations of changed resting potential and heart rate. Recent advances in theoretical approache...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1994-06, Vol.89 (6), p.2870-2878
Hauptverfasser:	VILLEMAIRE, C, NATTEL, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiarythmic agents Biological and medical sciences Cardiovascular system Dogs Female Heart Conduction System - drug effects Heart Conduction System - physiology Hyperkalemia - physiopathology Male Medical sciences Pharmacology. Drug treatments Potassium - pharmacology Procainamide - pharmacology Sodium Channels - drug effects
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