Frequency and significance of isolation of Ureaplasma urealyticum and Mycoplasma hominis from cerebrospinal fluid and tracheal aspirate specimens from low birth weight infants
To investigate the pathogenicity of Ureaplasma urealyticum and Mycoplasma hominis in preterm infants, we conducted a study to determine (1) frequency of isolation from cerebrospinal fluid and tracheal aspirate specimens and (2) clinical outcomes and effect of erythromycin treatment in ureaplasma-col...
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| Veröffentlicht in: | The Journal of pediatrics 1994-06, Vol.124 (6), p.956-961 |
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| container_title | The Journal of pediatrics |
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| creator | Heggie, Alfred D. Jacobs, Michael R. Butler, Verleria T. Baley, Jill E. Boxerbaum, Bernard |
| description | To investigate the pathogenicity of
Ureaplasma urealyticum and
Mycoplasma hominis in preterm infants, we conducted a study to determine (1) frequency of isolation from cerebrospinal fluid and tracheal aspirate specimens and (2) clinical outcomes and effect of erythromycin treatment in ureaplasma-colonized infants. From the cerebrospinal fluid of 920 infants,
U. urealyticum was isolated from 2 (0.2%) and
M. hominis from none. From tracheal aspirale specimens from 224 infants,
U. urealyticum was recovered from 37 (17%) and
M. hominis from 4 (2%). Demographic characteristics and clinical outcomes were compared in very low birth weight infants ( |
| doi_str_mv | 10.1016/S0022-3476(05)83192-0 |
| format | Article |
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Ureaplasma urealyticum and
Mycoplasma hominis in preterm infants, we conducted a study to determine (1) frequency of isolation from cerebrospinal fluid and tracheal aspirate specimens and (2) clinical outcomes and effect of erythromycin treatment in ureaplasma-colonized infants. From the cerebrospinal fluid of 920 infants,
U. urealyticum was isolated from 2 (0.2%) and
M. hominis from none. From tracheal aspirale specimens from 224 infants,
U. urealyticum was recovered from 37 (17%) and
M. hominis from 4 (2%). Demographic characteristics and clinical outcomes were compared in very low birth weight infants (<1500 gm) who were culture-positive or-negative for
U. urealyticum. Although infants with positive results were less mature than their cohorts with negative results, there were no substantive differences in clinical outcomes between the two groups. Initiation of erythromycin treatment of infants with positive ureaplasma culture results at a mean age of 16.4 days did not appear to alter the clinical outcome. We conclude that in preterm infants (1) infection of the cerebrospinal fluid by
U. urealyticum is infrequent, (2) ureaplasma organisms are frequently present in tracheal aspirate specimens but do not appear to be related to the presence or the subsequent development of respiratory disease, and (3) initiation of erythromycin treatment at 1 to 3 weeks of age does not alter the clinical course.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(05)83192-0</identifier><identifier>PMID: 8201486</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Bacterial diseases ; Biological and medical sciences ; Cerebrospinal Fluid - microbiology ; Erythromycin - therapeutic use ; Female ; Human bacterial diseases ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases - drug therapy ; Infant, Premature, Diseases - microbiology ; Infectious diseases ; Male ; Medical sciences ; Miscellaneous ; Mycoplasma - isolation & purification ; Trachea - microbiology ; Treatment Outcome ; Ureaplasma Infections - drug therapy ; Ureaplasma urealyticum - isolation & purification</subject><ispartof>The Journal of pediatrics, 1994-06, Vol.124 (6), p.956-961</ispartof><rights>1994 Mosby-Year Book, Inc.</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-7ae415bfbb0acfaffdccbd570522bba6553abec6bd69b075e00ebf1f6bd7e0723</citedby><cites>FETCH-LOGICAL-c389t-7ae415bfbb0acfaffdccbd570522bba6553abec6bd69b075e00ebf1f6bd7e0723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022347605831920$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4140239$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8201486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heggie, Alfred D.</creatorcontrib><creatorcontrib>Jacobs, Michael R.</creatorcontrib><creatorcontrib>Butler, Verleria T.</creatorcontrib><creatorcontrib>Baley, Jill E.</creatorcontrib><creatorcontrib>Boxerbaum, Bernard</creatorcontrib><title>Frequency and significance of isolation of Ureaplasma urealyticum and Mycoplasma hominis from cerebrospinal fluid and tracheal aspirate specimens from low birth weight infants</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>To investigate the pathogenicity of
Ureaplasma urealyticum and
Mycoplasma hominis in preterm infants, we conducted a study to determine (1) frequency of isolation from cerebrospinal fluid and tracheal aspirate specimens and (2) clinical outcomes and effect of erythromycin treatment in ureaplasma-colonized infants. From the cerebrospinal fluid of 920 infants,
U. urealyticum was isolated from 2 (0.2%) and
M. hominis from none. From tracheal aspirale specimens from 224 infants,
U. urealyticum was recovered from 37 (17%) and
M. hominis from 4 (2%). Demographic characteristics and clinical outcomes were compared in very low birth weight infants (<1500 gm) who were culture-positive or-negative for
U. urealyticum. Although infants with positive results were less mature than their cohorts with negative results, there were no substantive differences in clinical outcomes between the two groups. Initiation of erythromycin treatment of infants with positive ureaplasma culture results at a mean age of 16.4 days did not appear to alter the clinical outcome. We conclude that in preterm infants (1) infection of the cerebrospinal fluid by
U. urealyticum is infrequent, (2) ureaplasma organisms are frequently present in tracheal aspirate specimens but do not appear to be related to the presence or the subsequent development of respiratory disease, and (3) initiation of erythromycin treatment at 1 to 3 weeks of age does not alter the clinical course.</description><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Cerebrospinal Fluid - microbiology</subject><subject>Erythromycin - therapeutic use</subject><subject>Female</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infant, Low Birth Weight</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Premature, Diseases - drug therapy</subject><subject>Infant, Premature, Diseases - microbiology</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Mycoplasma - isolation & purification</subject><subject>Trachea - microbiology</subject><subject>Treatment Outcome</subject><subject>Ureaplasma Infections - drug therapy</subject><subject>Ureaplasma urealyticum - isolation & purification</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EKkvhJ1TyASE4BCbfyQlVFQWkIg7QszV2xt1Bib3YCdX-Kv4i3t1or5z88b7vjD2PEFc5vM8hbz78ACiKrKza5i3U77oy74sMnohNDn2bNV1ZPhWbs-W5eBHjLwDoK4ALcdEVkFddsxF_bwP9XsiZvUQ3yMgPji0bdIakt5KjH3Fm7w6H-0C4GzFOKJe0Hfczm2U65r7tjV-lrZ_YcZQ2-EkaCqSDjzt2OEo7Ljwc_XNAs00lJCYp4Ewy7sjwRG4Njv5Rag7zVj4SP2xnyc6im-NL8cziGOnVul6K-9tPP2--ZHffP3-9ub7LTNn1c9YiVXmtrdaAxqK1gzF6qFuoi0JrbOq6RE2m0UPTa2hrAiBtc5suWoK2KC_Fm1PdXfBpPnFWE0dD44iO_BJV29Rl0VWQjPXJaNI3YyCrdoEnDHuVgzqAUkdQ6kBBQa2OoNQhd7U2WPREwzm1kkn661XHaHC0ISHheLZVeQVF2Sfbx5ON0jD-MAUVDSecNHAgM6vB838e8g_uOrYZ</recordid><startdate>19940601</startdate><enddate>19940601</enddate><creator>Heggie, Alfred D.</creator><creator>Jacobs, Michael R.</creator><creator>Butler, Verleria T.</creator><creator>Baley, Jill E.</creator><creator>Boxerbaum, Bernard</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940601</creationdate><title>Frequency and significance of isolation of Ureaplasma urealyticum and Mycoplasma hominis from cerebrospinal fluid and tracheal aspirate specimens from low birth weight infants</title><author>Heggie, Alfred D. ; Jacobs, Michael R. ; Butler, Verleria T. ; Baley, Jill E. ; Boxerbaum, Bernard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-7ae415bfbb0acfaffdccbd570522bba6553abec6bd69b075e00ebf1f6bd7e0723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Cerebrospinal Fluid - microbiology</topic><topic>Erythromycin - therapeutic use</topic><topic>Female</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infant, Low Birth Weight</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infant, Premature, Diseases - drug therapy</topic><topic>Infant, Premature, Diseases - microbiology</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Mycoplasma - isolation & purification</topic><topic>Trachea - microbiology</topic><topic>Treatment Outcome</topic><topic>Ureaplasma Infections - drug therapy</topic><topic>Ureaplasma urealyticum - isolation & purification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heggie, Alfred D.</creatorcontrib><creatorcontrib>Jacobs, Michael R.</creatorcontrib><creatorcontrib>Butler, Verleria T.</creatorcontrib><creatorcontrib>Baley, Jill E.</creatorcontrib><creatorcontrib>Boxerbaum, Bernard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heggie, Alfred D.</au><au>Jacobs, Michael R.</au><au>Butler, Verleria T.</au><au>Baley, Jill E.</au><au>Boxerbaum, Bernard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Frequency and significance of isolation of Ureaplasma urealyticum and Mycoplasma hominis from cerebrospinal fluid and tracheal aspirate specimens from low birth weight infants</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1994-06-01</date><risdate>1994</risdate><volume>124</volume><issue>6</issue><spage>956</spage><epage>961</epage><pages>956-961</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>To investigate the pathogenicity of
Ureaplasma urealyticum and
Mycoplasma hominis in preterm infants, we conducted a study to determine (1) frequency of isolation from cerebrospinal fluid and tracheal aspirate specimens and (2) clinical outcomes and effect of erythromycin treatment in ureaplasma-colonized infants. From the cerebrospinal fluid of 920 infants,
U. urealyticum was isolated from 2 (0.2%) and
M. hominis from none. From tracheal aspirale specimens from 224 infants,
U. urealyticum was recovered from 37 (17%) and
M. hominis from 4 (2%). Demographic characteristics and clinical outcomes were compared in very low birth weight infants (<1500 gm) who were culture-positive or-negative for
U. urealyticum. Although infants with positive results were less mature than their cohorts with negative results, there were no substantive differences in clinical outcomes between the two groups. Initiation of erythromycin treatment of infants with positive ureaplasma culture results at a mean age of 16.4 days did not appear to alter the clinical outcome. We conclude that in preterm infants (1) infection of the cerebrospinal fluid by
U. urealyticum is infrequent, (2) ureaplasma organisms are frequently present in tracheal aspirate specimens but do not appear to be related to the presence or the subsequent development of respiratory disease, and (3) initiation of erythromycin treatment at 1 to 3 weeks of age does not alter the clinical course.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>8201486</pmid><doi>10.1016/S0022-3476(05)83192-0</doi><tpages>6</tpages></addata></record> |
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| subjects | Bacterial diseases Biological and medical sciences Cerebrospinal Fluid - microbiology Erythromycin - therapeutic use Female Human bacterial diseases Humans Infant, Low Birth Weight Infant, Newborn Infant, Premature Infant, Premature, Diseases - drug therapy Infant, Premature, Diseases - microbiology Infectious diseases Male Medical sciences Miscellaneous Mycoplasma - isolation & purification Trachea - microbiology Treatment Outcome Ureaplasma Infections - drug therapy Ureaplasma urealyticum - isolation & purification |
| title | Frequency and significance of isolation of Ureaplasma urealyticum and Mycoplasma hominis from cerebrospinal fluid and tracheal aspirate specimens from low birth weight infants |
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