Selected muscle and nerve extracts contain an activity which stimulates myoblast proliferation and which is distinct from transferrin
Extracts from normal chicken anterior latissimus dorsi and dystrophic pectoralis major muscles and from normal chicken sciatic nerves induce a growth stimulation in chicken and rat myogenic cell cultures. Transferrin is only partially responsible for the observed stimulation since the addition of th...
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| Veröffentlicht in: | Developmental biology 1985-12, Vol.112 (2), p.353-358 |
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| container_title | Developmental biology |
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| creator | Kardami, Elissavet Spector, Dennis Strohman, Richard C. |
| description | Extracts from normal chicken anterior latissimus dorsi and dystrophic pectoralis major muscles and from normal chicken sciatic nerves induce a growth stimulation in chicken and rat myogenic cell cultures. Transferrin is only partially responsible for the observed stimulation since the addition of the extracts to transferrin-saturated cultures induces a further growth response and extracts from which transferrin has been removed by immunoabsorption still retain a substantial portion of their stimulation activity. The active fractions of muscle and nerve extracts display heat, acid, and organic solvent inactivation. Gel filtration of ammonium sulfate fractionated activity from the anterior latissimus dorsi muscle suggests the presence of a growth factor in the molecular weight range of 10,000 to 30,000. |
| doi_str_mv | 10.1016/0012-1606(85)90406-3 |
| format | Article |
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Transferrin is only partially responsible for the observed stimulation since the addition of the extracts to transferrin-saturated cultures induces a further growth response and extracts from which transferrin has been removed by immunoabsorption still retain a substantial portion of their stimulation activity. The active fractions of muscle and nerve extracts display heat, acid, and organic solvent inactivation. Gel filtration of ammonium sulfate fractionated activity from the anterior latissimus dorsi muscle suggests the presence of a growth factor in the molecular weight range of 10,000 to 30,000.</description><identifier>ISSN: 0012-1606</identifier><identifier>EISSN: 1095-564X</identifier><identifier>DOI: 10.1016/0012-1606(85)90406-3</identifier><identifier>PMID: 3908194</identifier><identifier>CODEN: DEBIAO</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Analytical, structural and metabolic biochemistry ; Animals ; Biological and medical sciences ; Cell Differentiation ; Cell Division ; Cell Line ; Chick Embryo ; Chickens ; Chromatography ; Fractional Precipitation ; Fundamental and applied biological sciences. Psychology ; Growth Substances - isolation & purification ; Growth Substances - pharmacology ; Immunosorbent Techniques ; Molecular Weight ; Muscles - analysis ; Muscles - cytology ; Muscles - metabolism ; Muscular Dystrophy, Animal - metabolism ; Myosins - metabolism ; Protein hormones. Growth factors. Cytokines ; Proteins ; Rats ; Sciatic Nerve - analysis ; Transferrin - pharmacology</subject><ispartof>Developmental biology, 1985-12, Vol.112 (2), p.353-358</ispartof><rights>1985</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-15a3a9a3c5d5b0a6ca311d5bbe94ffba73f2425b333e7faad23fdde0c29598a93</citedby><cites>FETCH-LOGICAL-c386t-15a3a9a3c5d5b0a6ca311d5bbe94ffba73f2425b333e7faad23fdde0c29598a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0012-1606(85)90406-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8742712$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3908194$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kardami, Elissavet</creatorcontrib><creatorcontrib>Spector, Dennis</creatorcontrib><creatorcontrib>Strohman, Richard C.</creatorcontrib><title>Selected muscle and nerve extracts contain an activity which stimulates myoblast proliferation and which is distinct from transferrin</title><title>Developmental biology</title><addtitle>Dev Biol</addtitle><description>Extracts from normal chicken anterior latissimus dorsi and dystrophic pectoralis major muscles and from normal chicken sciatic nerves induce a growth stimulation in chicken and rat myogenic cell cultures. Transferrin is only partially responsible for the observed stimulation since the addition of the extracts to transferrin-saturated cultures induces a further growth response and extracts from which transferrin has been removed by immunoabsorption still retain a substantial portion of their stimulation activity. The active fractions of muscle and nerve extracts display heat, acid, and organic solvent inactivation. Gel filtration of ammonium sulfate fractionated activity from the anterior latissimus dorsi muscle suggests the presence of a growth factor in the molecular weight range of 10,000 to 30,000.</description><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Differentiation</subject><subject>Cell Division</subject><subject>Cell Line</subject><subject>Chick Embryo</subject><subject>Chickens</subject><subject>Chromatography</subject><subject>Fractional Precipitation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Growth Substances - isolation & purification</subject><subject>Growth Substances - pharmacology</subject><subject>Immunosorbent Techniques</subject><subject>Molecular Weight</subject><subject>Muscles - analysis</subject><subject>Muscles - cytology</subject><subject>Muscles - metabolism</subject><subject>Muscular Dystrophy, Animal - metabolism</subject><subject>Myosins - metabolism</subject><subject>Protein hormones. Growth factors. Cytokines</subject><subject>Proteins</subject><subject>Rats</subject><subject>Sciatic Nerve - analysis</subject><subject>Transferrin - pharmacology</subject><issn>0012-1606</issn><issn>1095-564X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2KFDEURoM4jO3oGyhkIYMuSpNKJVW1EWTwDwZmoYK7cCu5YSKp1Jik2ukH8L1NTze9dJWE79yPywkhLzh7yxlX7xjjbcMVU68H-WZkHVONeEQ2nI2ykar7-ZhsTsgT8jTnX4wxMQzinJyLkQ187Dbk7zcMaApaOq_ZBKQQLY2YtkjxviQwJVOzxAI-1ojWt9_6sqN_br25pbn4eQ1QMNN5t0wBcqF3aQneYYLil_hQd2B9ptbXgWgKdWmZaW2PuYLJx2fkzEHI-Px4XpAfnz5-v_rSXN98_nr14boxYlCl4RIEjCCMtHJioAwIzut1wrFzboJeuLZr5SSEwN4B2FY4a5GZdpTjAKO4IJeH3rrk7xVz0bPPBkOAiMuada-kaAVXFewOoElLzgmdvkt-hrTTnOm9fb1Xq_dq9SD1g30t6tjLY_86zWhPQ0fdNX91zCEbCK4aMD6fsKHv2p63FXt_wLC62HpMOhuP0aD1qX6Wtov__x7_AH0kpLw</recordid><startdate>198512</startdate><enddate>198512</enddate><creator>Kardami, Elissavet</creator><creator>Spector, Dennis</creator><creator>Strohman, Richard C.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198512</creationdate><title>Selected muscle and nerve extracts contain an activity which stimulates myoblast proliferation and which is distinct from transferrin</title><author>Kardami, Elissavet ; Spector, Dennis ; Strohman, Richard C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-15a3a9a3c5d5b0a6ca311d5bbe94ffba73f2425b333e7faad23fdde0c29598a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Differentiation</topic><topic>Cell Division</topic><topic>Cell Line</topic><topic>Chick Embryo</topic><topic>Chickens</topic><topic>Chromatography</topic><topic>Fractional Precipitation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Growth Substances - isolation & purification</topic><topic>Growth Substances - pharmacology</topic><topic>Immunosorbent Techniques</topic><topic>Molecular Weight</topic><topic>Muscles - analysis</topic><topic>Muscles - cytology</topic><topic>Muscles - metabolism</topic><topic>Muscular Dystrophy, Animal - metabolism</topic><topic>Myosins - metabolism</topic><topic>Protein hormones. Growth factors. Cytokines</topic><topic>Proteins</topic><topic>Rats</topic><topic>Sciatic Nerve - analysis</topic><topic>Transferrin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kardami, Elissavet</creatorcontrib><creatorcontrib>Spector, Dennis</creatorcontrib><creatorcontrib>Strohman, Richard C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kardami, Elissavet</au><au>Spector, Dennis</au><au>Strohman, Richard C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selected muscle and nerve extracts contain an activity which stimulates myoblast proliferation and which is distinct from transferrin</atitle><jtitle>Developmental biology</jtitle><addtitle>Dev Biol</addtitle><date>1985-12</date><risdate>1985</risdate><volume>112</volume><issue>2</issue><spage>353</spage><epage>358</epage><pages>353-358</pages><issn>0012-1606</issn><eissn>1095-564X</eissn><coden>DEBIAO</coden><abstract>Extracts from normal chicken anterior latissimus dorsi and dystrophic pectoralis major muscles and from normal chicken sciatic nerves induce a growth stimulation in chicken and rat myogenic cell cultures. Transferrin is only partially responsible for the observed stimulation since the addition of the extracts to transferrin-saturated cultures induces a further growth response and extracts from which transferrin has been removed by immunoabsorption still retain a substantial portion of their stimulation activity. The active fractions of muscle and nerve extracts display heat, acid, and organic solvent inactivation. Gel filtration of ammonium sulfate fractionated activity from the anterior latissimus dorsi muscle suggests the presence of a growth factor in the molecular weight range of 10,000 to 30,000.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>3908194</pmid><doi>10.1016/0012-1606(85)90406-3</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-1606 |
| ispartof | Developmental biology, 1985-12, Vol.112 (2), p.353-358 |
| issn | 0012-1606 1095-564X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Cell Differentiation Cell Division Cell Line Chick Embryo Chickens Chromatography Fractional Precipitation Fundamental and applied biological sciences. Psychology Growth Substances - isolation & purification Growth Substances - pharmacology Immunosorbent Techniques Molecular Weight Muscles - analysis Muscles - cytology Muscles - metabolism Muscular Dystrophy, Animal - metabolism Myosins - metabolism Protein hormones. Growth factors. Cytokines Proteins Rats Sciatic Nerve - analysis Transferrin - pharmacology |
| title | Selected muscle and nerve extracts contain an activity which stimulates myoblast proliferation and which is distinct from transferrin |
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