Soluble CTLA-4 can suppress autoantibody production and elicit long term unresponsiveness in a novel transgenic model

Activation of Ag-specific T cells often requires costimulatory signals in addition to the primary signal mediated through the TCR. The CD28-B7 interaction provides one important costimulatory signal. Previous studies have shown that a soluble CD28 homologue, CTLA4lg, binds B7 with high affinity and...

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