Isolation of yeast artificial chromosome clones from 54 polymorphic loci mapped with high odds on human chromosome 4
We constructed a yeast artificial chromosome (YAC) framework map of human chromosome 4 by screening a YAC library with 63 polymorphic DNA markers located on the chromosome. These genetic markers are from two framework melotic maps that had previously been constructed by two research groups, and are...
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| Veröffentlicht in: | Human molecular genetics 1994-02, Vol.3 (2), p.243-246 |
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| container_title | Human molecular genetics |
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| creator | Fan, Jlan-Bing DeYoung, Joe Lagacé, Rob Lina, R.Andrea Xu, Zhldong Murray, Jeffrey C. Buetow, Kenneth H. Weissenbach, Jean Goold, Richard D. Cox, David R. Myers, Richard M. |
| description | We constructed a yeast artificial chromosome (YAC) framework map of human chromosome 4 by screening a YAC library with 63 polymorphic DNA markers located on the chromosome. These genetic markers are from two framework melotic maps that had previously been constructed by two research groups, and are placed on the two maps with odds for their order of 1000: 1 or greater. In addition to Isolating and determining the sizes of 141 YAC clones for 54 of these markers, we combined the two framework melotic maps to produce a single Integrated map. These combined maps and the YAC clones provide a set of extended DNA loci ordered at high odds that can be used to isolate additional polymorphic loci and genes, and to serve as a framework for obtaining a higher resolution physical map of the chromosome. |
| doi_str_mv | 10.1093/hmg/3.2.243 |
| format | Article |
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These genetic markers are from two framework melotic maps that had previously been constructed by two research groups, and are placed on the two maps with odds for their order of 1000: 1 or greater. In addition to Isolating and determining the sizes of 141 YAC clones for 54 of these markers, we combined the two framework melotic maps to produce a single Integrated map. These combined maps and the YAC clones provide a set of extended DNA loci ordered at high odds that can be used to isolate additional polymorphic loci and genes, and to serve as a framework for obtaining a higher resolution physical map of the chromosome.</description><identifier>ISSN: 0964-6906</identifier><identifier>EISSN: 1460-2083</identifier><identifier>DOI: 10.1093/hmg/3.2.243</identifier><identifier>PMID: 8004089</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Biological and medical sciences ; chromosome 4 ; Chromosome Mapping ; Chromosomes, Artificial, Yeast ; Chromosomes, Human, Pair 4 ; Classical genetics, quantitative genetics, hybrids ; DNA ; Fundamental and applied biological sciences. Psychology ; Genetic Linkage ; Genetic Markers ; Genetics of eukaryotes. Biological and molecular evolution ; Human ; Humans ; man ; mapping ; Meiosis ; Polymorphism, Genetic ; Sequence Tagged Sites ; yeast artificial chromosomes</subject><ispartof>Human molecular genetics, 1994-02, Vol.3 (2), p.243-246</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-26fc648eef260ed30385c2ba04b1b193d6516f882ada69b825cbadde3e836f4c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4031319$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8004089$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fan, Jlan-Bing</creatorcontrib><creatorcontrib>DeYoung, Joe</creatorcontrib><creatorcontrib>Lagacé, Rob</creatorcontrib><creatorcontrib>Lina, R.Andrea</creatorcontrib><creatorcontrib>Xu, Zhldong</creatorcontrib><creatorcontrib>Murray, Jeffrey C.</creatorcontrib><creatorcontrib>Buetow, Kenneth H.</creatorcontrib><creatorcontrib>Weissenbach, Jean</creatorcontrib><creatorcontrib>Goold, Richard D.</creatorcontrib><creatorcontrib>Cox, David R.</creatorcontrib><creatorcontrib>Myers, Richard M.</creatorcontrib><title>Isolation of yeast artificial chromosome clones from 54 polymorphic loci mapped with high odds on human chromosome 4</title><title>Human molecular genetics</title><addtitle>Hum Mol Genet</addtitle><description>We constructed a yeast artificial chromosome (YAC) framework map of human chromosome 4 by screening a YAC library with 63 polymorphic DNA markers located on the chromosome. These genetic markers are from two framework melotic maps that had previously been constructed by two research groups, and are placed on the two maps with odds for their order of 1000: 1 or greater. In addition to Isolating and determining the sizes of 141 YAC clones for 54 of these markers, we combined the two framework melotic maps to produce a single Integrated map. These combined maps and the YAC clones provide a set of extended DNA loci ordered at high odds that can be used to isolate additional polymorphic loci and genes, and to serve as a framework for obtaining a higher resolution physical map of the chromosome.</description><subject>Biological and medical sciences</subject><subject>chromosome 4</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Artificial, Yeast</subject><subject>Chromosomes, Human, Pair 4</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>DNA</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Linkage</subject><subject>Genetic Markers</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Human</subject><subject>Humans</subject><subject>man</subject><subject>mapping</subject><subject>Meiosis</subject><subject>Polymorphism, Genetic</subject><subject>Sequence Tagged Sites</subject><subject>yeast artificial chromosomes</subject><issn>0964-6906</issn><issn>1460-2083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0b1r3DAYBnBRWtJL2qlzQUPpEnyR9MqyPJaQLxrIksLRRcj6iNValiv5SO-_j8MdR7dOgvf58Qx6EPpEyZqSFi76-HQBa7ZmHN6gFeWCVIxIeItWpBW8Ei0R79FpKb8IoYJDc4JOJCGcyHaF5ruSBj2HNOLk8c7pMmOd5-CDCXrAps8pppKiw2ZIoyvYLwdcczylYRdTnvpg8JBMwFFPk7P4Ocw97sNTj5O1BS-9_Tbq8d8m_gG983oo7uPhPUM_rq8eL2-r-4ebu8tv95UByeaKCW8El855JoizQEDWhnWa8I52tAUraiq8lExbLdpOstp02loHToLw3MAZ-rrvnXL6s3VlVjEU44ZBjy5ti2pEzVpe8_9CKpoGSCsXeL6HJqdSsvNqyiHqvFOUqNcx1DKGAsXUMsaiPx9qt1109mgPv7_kXw65LkYPPuvRhHJknAAF-sqqPQtldn-Psc6_lWigqdXt5qfafL_Z0OsGFIEXMo2iUA</recordid><startdate>19940201</startdate><enddate>19940201</enddate><creator>Fan, Jlan-Bing</creator><creator>DeYoung, Joe</creator><creator>Lagacé, Rob</creator><creator>Lina, R.Andrea</creator><creator>Xu, Zhldong</creator><creator>Murray, Jeffrey C.</creator><creator>Buetow, Kenneth H.</creator><creator>Weissenbach, Jean</creator><creator>Goold, Richard D.</creator><creator>Cox, David R.</creator><creator>Myers, Richard M.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T3</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19940201</creationdate><title>Isolation of yeast artificial chromosome clones from 54 polymorphic loci mapped with high odds on human chromosome 4</title><author>Fan, Jlan-Bing ; DeYoung, Joe ; Lagacé, Rob ; Lina, R.Andrea ; Xu, Zhldong ; Murray, Jeffrey C. ; Buetow, Kenneth H. ; Weissenbach, Jean ; Goold, Richard D. ; Cox, David R. ; Myers, Richard M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-26fc648eef260ed30385c2ba04b1b193d6516f882ada69b825cbadde3e836f4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Biological and medical sciences</topic><topic>chromosome 4</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Artificial, Yeast</topic><topic>Chromosomes, Human, Pair 4</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>DNA</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Linkage</topic><topic>Genetic Markers</topic><topic>Genetics of eukaryotes. 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These genetic markers are from two framework melotic maps that had previously been constructed by two research groups, and are placed on the two maps with odds for their order of 1000: 1 or greater. In addition to Isolating and determining the sizes of 141 YAC clones for 54 of these markers, we combined the two framework melotic maps to produce a single Integrated map. These combined maps and the YAC clones provide a set of extended DNA loci ordered at high odds that can be used to isolate additional polymorphic loci and genes, and to serve as a framework for obtaining a higher resolution physical map of the chromosome.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>8004089</pmid><doi>10.1093/hmg/3.2.243</doi><tpages>4</tpages></addata></record> |
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| ispartof | Human molecular genetics, 1994-02, Vol.3 (2), p.243-246 |
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| language | eng |
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| source | Oxford University Press Journals Digital Archive legacy; MEDLINE |
| subjects | Biological and medical sciences chromosome 4 Chromosome Mapping Chromosomes, Artificial, Yeast Chromosomes, Human, Pair 4 Classical genetics, quantitative genetics, hybrids DNA Fundamental and applied biological sciences. Psychology Genetic Linkage Genetic Markers Genetics of eukaryotes. Biological and molecular evolution Human Humans man mapping Meiosis Polymorphism, Genetic Sequence Tagged Sites yeast artificial chromosomes |
| title | Isolation of yeast artificial chromosome clones from 54 polymorphic loci mapped with high odds on human chromosome 4 |
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