Pretreatment Plasma Levels of Fibrinopeptide-A (FPA), D-Dimer (DD), and von Willebrand Factor (vWF) in Patients with Ovarian Carcinoma
The preoperative plasma levels of fibrinopeptide-A (FPA), D-dimer (DD), and von Willebrand Factor (vWF) were measured in 125 patients with ovarian masses undergoing laparotomy and in 88 healthy nonpregnant women as controls. FPA, DD, and vWF levels were significantly higher in the 58 patients with o...
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| Veröffentlicht in: | Gynecologic oncology 1994-06, Vol.53 (3), p.352-356 |
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| creator | Gadducci, Angiolo Baicchi, Ugo Marrai, Roberto Del Bravo, Barbara Fosella, Pier Vittorio Facchini, Virgilio |
| description | The preoperative plasma levels of fibrinopeptide-A (FPA), D-dimer (DD), and von Willebrand Factor (vWF) were measured in 125 patients with ovarian masses undergoing laparotomy and in 88 healthy nonpregnant women as controls. FPA, DD, and vWF levels were significantly higher in the 58 patients with ovarian carcinoma than in the 67 patients with benign ovarian disease or controls. FPA and DD values were significantly higher in advanced (FIGO stage III-IV) than in early ovarian carcinoma. Among patients with advanced disease, FPA and DD levels correlated with none of the common clinicopathological prognostic variables; conversely, vWF values were related to FIGO stage (IV versus III, P < 0.02) and size of residual disease after initial surgery (>2 cm versus ⩽2 cm, P < 0.05). In conclusion, increased fibrin production and degradation occur in patients with ovarian carcinoma. |
| doi_str_mv | 10.1006/gyno.1994.1146 |
| format | Article |
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FPA, DD, and vWF levels were significantly higher in the 58 patients with ovarian carcinoma than in the 67 patients with benign ovarian disease or controls. FPA and DD values were significantly higher in advanced (FIGO stage III-IV) than in early ovarian carcinoma. Among patients with advanced disease, FPA and DD levels correlated with none of the common clinicopathological prognostic variables; conversely, vWF values were related to FIGO stage (IV versus III, P < 0.02) and size of residual disease after initial surgery (>2 cm versus ⩽2 cm, P < 0.05). In conclusion, increased fibrin production and degradation occur in patients with ovarian carcinoma.</description><identifier>ISSN: 0090-8258</identifier><identifier>EISSN: 1095-6859</identifier><identifier>DOI: 10.1006/gyno.1994.1146</identifier><identifier>PMID: 8206409</identifier><identifier>CODEN: GYNOA3</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Female ; Female genital diseases ; Fibrin - biosynthesis ; Fibrin - metabolism ; Fibrin Fibrinogen Degradation Products - metabolism ; Fibrinopeptide A - metabolism ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Middle Aged ; Neoplasm Staging ; Ovarian Diseases - blood ; Ovarian Diseases - pathology ; Ovarian Neoplasms - blood ; Ovarian Neoplasms - pathology ; Ovarian Neoplasms - surgery ; Predictive Value of Tests ; Sensitivity and Specificity ; Tumors ; von Willebrand Factor - metabolism</subject><ispartof>Gynecologic oncology, 1994-06, Vol.53 (3), p.352-356</ispartof><rights>1994 Academic Press</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-d03564200ba8834c9d5984357ea6f6dda6e6b8f985c18d1692f3101cf232aa3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0090825884711462$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4186019$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8206409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gadducci, Angiolo</creatorcontrib><creatorcontrib>Baicchi, Ugo</creatorcontrib><creatorcontrib>Marrai, Roberto</creatorcontrib><creatorcontrib>Del Bravo, Barbara</creatorcontrib><creatorcontrib>Fosella, Pier Vittorio</creatorcontrib><creatorcontrib>Facchini, Virgilio</creatorcontrib><title>Pretreatment Plasma Levels of Fibrinopeptide-A (FPA), D-Dimer (DD), and von Willebrand Factor (vWF) in Patients with Ovarian Carcinoma</title><title>Gynecologic oncology</title><addtitle>Gynecol Oncol</addtitle><description>The preoperative plasma levels of fibrinopeptide-A (FPA), D-dimer (DD), and von Willebrand Factor (vWF) were measured in 125 patients with ovarian masses undergoing laparotomy and in 88 healthy nonpregnant women as controls. FPA, DD, and vWF levels were significantly higher in the 58 patients with ovarian carcinoma than in the 67 patients with benign ovarian disease or controls. FPA and DD values were significantly higher in advanced (FIGO stage III-IV) than in early ovarian carcinoma. Among patients with advanced disease, FPA and DD levels correlated with none of the common clinicopathological prognostic variables; conversely, vWF values were related to FIGO stage (IV versus III, P < 0.02) and size of residual disease after initial surgery (>2 cm versus ⩽2 cm, P < 0.05). In conclusion, increased fibrin production and degradation occur in patients with ovarian carcinoma.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Fibrin - biosynthesis</subject><subject>Fibrin - metabolism</subject><subject>Fibrin Fibrinogen Degradation Products - metabolism</subject><subject>Fibrinopeptide A - metabolism</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Ovarian Diseases - blood</subject><subject>Ovarian Diseases - pathology</subject><subject>Ovarian Neoplasms - blood</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Ovarian Neoplasms - surgery</subject><subject>Predictive Value of Tests</subject><subject>Sensitivity and Specificity</subject><subject>Tumors</subject><subject>von Willebrand Factor - metabolism</subject><issn>0090-8258</issn><issn>1095-6859</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1rGzEQhkVpSd00194KOpSQQNeR9kOWjsbuNgVDDC3kKGal2VZlP1xJ3pI_0N9dLTa55TQM76N3xEPIB86WnDFx9_NpGJdcqXLJeSlekQVnqsqErNRrsmBMsUzmlXxL3oXwmzFWMJ5fkAuZM1EytSD_9h6jR4g9DpHuOwg90B1O2AU6trR2jXfDeMBDdBazNb2p9-vbz3SbbV2Pnt5st2mDwdJpHOij6zps_LzWYOKY8umxvqVuoHuILl0I9K-Lv-jDBN7BQDfgTarv4T1500IX8Oo8L8n3-suPzX22e_j6bbPeZaYQMmaWFZUoc8YakLIojbKVkmVRrRBEK6wFgaKRrZKV4dJyofK24IybNi9ygOKSXJ9aD378c8QQde-Cwa6DAcdj0CtR5auCiwQuT6DxYwgeW33wrgf_pDnTs3Y9a9ezdj1rTw8-npuPTY_2GT97Tvmncw7BQNcmR8aFZ6zkUjA-Y_KEJf04OfQ6mKTNoHUeTdR2dC_94D87vZx1</recordid><startdate>19940601</startdate><enddate>19940601</enddate><creator>Gadducci, Angiolo</creator><creator>Baicchi, Ugo</creator><creator>Marrai, Roberto</creator><creator>Del Bravo, Barbara</creator><creator>Fosella, Pier Vittorio</creator><creator>Facchini, Virgilio</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940601</creationdate><title>Pretreatment Plasma Levels of Fibrinopeptide-A (FPA), D-Dimer (DD), and von Willebrand Factor (vWF) in Patients with Ovarian Carcinoma</title><author>Gadducci, Angiolo ; Baicchi, Ugo ; Marrai, Roberto ; Del Bravo, Barbara ; Fosella, Pier Vittorio ; Facchini, Virgilio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-d03564200ba8834c9d5984357ea6f6dda6e6b8f985c18d1692f3101cf232aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Fibrin - biosynthesis</topic><topic>Fibrin - metabolism</topic><topic>Fibrin Fibrinogen Degradation Products - metabolism</topic><topic>Fibrinopeptide A - metabolism</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Ovarian Diseases - blood</topic><topic>Ovarian Diseases - pathology</topic><topic>Ovarian Neoplasms - blood</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Ovarian Neoplasms - surgery</topic><topic>Predictive Value of Tests</topic><topic>Sensitivity and Specificity</topic><topic>Tumors</topic><topic>von Willebrand Factor - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gadducci, Angiolo</creatorcontrib><creatorcontrib>Baicchi, Ugo</creatorcontrib><creatorcontrib>Marrai, Roberto</creatorcontrib><creatorcontrib>Del Bravo, Barbara</creatorcontrib><creatorcontrib>Fosella, Pier Vittorio</creatorcontrib><creatorcontrib>Facchini, Virgilio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecologic oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gadducci, Angiolo</au><au>Baicchi, Ugo</au><au>Marrai, Roberto</au><au>Del Bravo, Barbara</au><au>Fosella, Pier Vittorio</au><au>Facchini, Virgilio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pretreatment Plasma Levels of Fibrinopeptide-A (FPA), D-Dimer (DD), and von Willebrand Factor (vWF) in Patients with Ovarian Carcinoma</atitle><jtitle>Gynecologic oncology</jtitle><addtitle>Gynecol Oncol</addtitle><date>1994-06-01</date><risdate>1994</risdate><volume>53</volume><issue>3</issue><spage>352</spage><epage>356</epage><pages>352-356</pages><issn>0090-8258</issn><eissn>1095-6859</eissn><coden>GYNOA3</coden><abstract>The preoperative plasma levels of fibrinopeptide-A (FPA), D-dimer (DD), and von Willebrand Factor (vWF) were measured in 125 patients with ovarian masses undergoing laparotomy and in 88 healthy nonpregnant women as controls. FPA, DD, and vWF levels were significantly higher in the 58 patients with ovarian carcinoma than in the 67 patients with benign ovarian disease or controls. FPA and DD values were significantly higher in advanced (FIGO stage III-IV) than in early ovarian carcinoma. Among patients with advanced disease, FPA and DD levels correlated with none of the common clinicopathological prognostic variables; conversely, vWF values were related to FIGO stage (IV versus III, P < 0.02) and size of residual disease after initial surgery (>2 cm versus ⩽2 cm, P < 0.05). In conclusion, increased fibrin production and degradation occur in patients with ovarian carcinoma.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>8206409</pmid><doi>10.1006/gyno.1994.1146</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Female Female genital diseases Fibrin - biosynthesis Fibrin - metabolism Fibrin Fibrinogen Degradation Products - metabolism Fibrinopeptide A - metabolism Gynecology. Andrology. Obstetrics Humans Medical sciences Middle Aged Neoplasm Staging Ovarian Diseases - blood Ovarian Diseases - pathology Ovarian Neoplasms - blood Ovarian Neoplasms - pathology Ovarian Neoplasms - surgery Predictive Value of Tests Sensitivity and Specificity Tumors von Willebrand Factor - metabolism |
| title | Pretreatment Plasma Levels of Fibrinopeptide-A (FPA), D-Dimer (DD), and von Willebrand Factor (vWF) in Patients with Ovarian Carcinoma |
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