Augmented local immunity in the liver by a streptococcal preparation, OK432, related to antitumor activity of hepatic macrophages
The aim of this study was to investigate the augmentative effect of a streptoccal preparation, OK432, on the immunological competence of hepatic macrophages. We found that OK432 was distributed predominantly to hepatic macrophages after intravenous injection, and Northern blot analysis revealed that...
Gespeichert in:
| Veröffentlicht in: | Immunopharmacology 1994-01, Vol.27 (1), p.31-41 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 41 |
|---|---|
| container_issue | 1 |
| container_start_page | 31 |
| container_title | Immunopharmacology |
| container_volume | 27 |
| creator | Mise, Masahiro Arii, Shigeki Higashitsuji, Hiroaki Furutani, Masaharu Monden, Kazunobu Adachi, Yukito Funaki, Naomi Fujita, Shinichi Ishiguro, Satoshi Kitao, Tadahiro Nakamura, Toshio Fujita, Jun Nakayama, Hiroki Imamura, Masayuki |
| description | The aim of this study was to investigate the augmentative effect of a streptoccal preparation, OK432, on the immunological competence of hepatic macrophages. We found that OK432 was distributed predominantly to hepatic macrophages after intravenous injection, and Northern blot analysis revealed that OK432 induced the gene expression of IL-1α, β, and TNFα in the liver. The induction of mRNAs was evident 1 h after the intravenous injection of OK432 and their accumulation reached a maximal level at 3 h. TNF production of hepatic macrophages was also increased by the intravenous injection of OK432. Furthermore, OK432 significantly increased the proportion of IL-2 receptor-positive hepatic macrophages. As for antitumor activity in the liver being augmented by OK432, the cytotoxic and cytostatic activity of hepatic macrophages from OK432-treated rats against tumor cells was significantly increased and OK432 markedly reduced the number of tumor nodules in the liver after the inoculation of tumor cells via the portal vein. These findings, which indicated that OK432 has various immuno-stimulating actions on hepatic macrophages, leading to the augmentation of antitumor activity in the liver, suggest that OK432 may be of some benefit in helping to prevent hepatic metastasis, at least in part, via its activation of hepatic macrophages. |
| doi_str_mv | 10.1016/0162-3109(94)90005-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76522691</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0162310994900051</els_id><sourcerecordid>16970490</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-7863b3915c479249340bdf0e6e3d8ded4321bfbc08d84d1c89ada6d9f30feddc3</originalsourceid><addsrcrecordid>eNqFkU1v3CAQhjm02m43_QeNxCGKGmndgsEfXCqtoiStGimX9owwjLNEtnEAr7TH_PPg7mqPyQEhZp55h3kHoa-UfKeElj_SyTNGifgm-JUghBQZ_YCWp_An9DmEpxTnlSgWaFHnpKyKfIleNtNjD0MEgzunVYdt30-DjXtsBxy3gDu7A4-bPVY4RA9jdNrpGRzTQ3kVrRvW-OEPZ_kae-jULBUdVkO0ceqdx0pHu5sVXYu3qSZajXulvRu36hHCGfrYqi7Al-O9Qv9ub_5e_8ruH-5-X2_uM81pFbOqLlnDBC10GiHngnHSmJZACczUBkzqT5u20aQ2NTdU10IZVRrRMtKCMZqt0OVBd_TueYIQZW-Dhq5TA7gpyKos8rwU9F2QlqIiXJAE8gOYZgnBQytHb3vl95ISOa9Fzv7L2X8puPy_Fjnrnx_1p6YHcyo67iTlL455FZLRrVeDtuGEMcETxxL284BBMm1nwcugLQwajPWgozTOvv2PV4-IrJU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16970490</pqid></control><display><type>article</type><title>Augmented local immunity in the liver by a streptococcal preparation, OK432, related to antitumor activity of hepatic macrophages</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Mise, Masahiro ; Arii, Shigeki ; Higashitsuji, Hiroaki ; Furutani, Masaharu ; Monden, Kazunobu ; Adachi, Yukito ; Funaki, Naomi ; Fujita, Shinichi ; Ishiguro, Satoshi ; Kitao, Tadahiro ; Nakamura, Toshio ; Fujita, Jun ; Nakayama, Hiroki ; Imamura, Masayuki</creator><creatorcontrib>Mise, Masahiro ; Arii, Shigeki ; Higashitsuji, Hiroaki ; Furutani, Masaharu ; Monden, Kazunobu ; Adachi, Yukito ; Funaki, Naomi ; Fujita, Shinichi ; Ishiguro, Satoshi ; Kitao, Tadahiro ; Nakamura, Toshio ; Fujita, Jun ; Nakayama, Hiroki ; Imamura, Masayuki</creatorcontrib><description>The aim of this study was to investigate the augmentative effect of a streptoccal preparation, OK432, on the immunological competence of hepatic macrophages. We found that OK432 was distributed predominantly to hepatic macrophages after intravenous injection, and Northern blot analysis revealed that OK432 induced the gene expression of IL-1α, β, and TNFα in the liver. The induction of mRNAs was evident 1 h after the intravenous injection of OK432 and their accumulation reached a maximal level at 3 h. TNF production of hepatic macrophages was also increased by the intravenous injection of OK432. Furthermore, OK432 significantly increased the proportion of IL-2 receptor-positive hepatic macrophages. As for antitumor activity in the liver being augmented by OK432, the cytotoxic and cytostatic activity of hepatic macrophages from OK432-treated rats against tumor cells was significantly increased and OK432 markedly reduced the number of tumor nodules in the liver after the inoculation of tumor cells via the portal vein. These findings, which indicated that OK432 has various immuno-stimulating actions on hepatic macrophages, leading to the augmentation of antitumor activity in the liver, suggest that OK432 may be of some benefit in helping to prevent hepatic metastasis, at least in part, via its activation of hepatic macrophages.</description><identifier>ISSN: 0162-3109</identifier><identifier>DOI: 10.1016/0162-3109(94)90005-1</identifier><identifier>PMID: 8206752</identifier><identifier>CODEN: IMMUDP</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Antineoplastic agents ; Biological and medical sciences ; Cytotoxicity, Immunologic - drug effects ; Hepatic macrophage ; Humans ; IL-1αmRNA ; IL-1βmRNA ; IL-2 receptor ; Immunotherapy ; In Vitro Techniques ; Interleukin-1 - biosynthesis ; Liver - immunology ; Liver - metabolism ; Liver Neoplasms - immunology ; Macrophage Activation - physiology ; Male ; Medical sciences ; OK432 ; Pharmacology. Drug treatments ; Picibanil - pharmacokinetics ; Picibanil - pharmacology ; Rats ; Receptors, Interleukin-2 - biosynthesis ; RNA, Messenger - biosynthesis ; Streptococcus ; TNFαmRNA ; Tumor Cells, Cultured ; Tumor Necrosis Factor-alpha - biosynthesis</subject><ispartof>Immunopharmacology, 1994-01, Vol.27 (1), p.31-41</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-7863b3915c479249340bdf0e6e3d8ded4321bfbc08d84d1c89ada6d9f30feddc3</citedby><cites>FETCH-LOGICAL-c417t-7863b3915c479249340bdf0e6e3d8ded4321bfbc08d84d1c89ada6d9f30feddc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,4025,27925,27926,27927</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3940673$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8206752$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mise, Masahiro</creatorcontrib><creatorcontrib>Arii, Shigeki</creatorcontrib><creatorcontrib>Higashitsuji, Hiroaki</creatorcontrib><creatorcontrib>Furutani, Masaharu</creatorcontrib><creatorcontrib>Monden, Kazunobu</creatorcontrib><creatorcontrib>Adachi, Yukito</creatorcontrib><creatorcontrib>Funaki, Naomi</creatorcontrib><creatorcontrib>Fujita, Shinichi</creatorcontrib><creatorcontrib>Ishiguro, Satoshi</creatorcontrib><creatorcontrib>Kitao, Tadahiro</creatorcontrib><creatorcontrib>Nakamura, Toshio</creatorcontrib><creatorcontrib>Fujita, Jun</creatorcontrib><creatorcontrib>Nakayama, Hiroki</creatorcontrib><creatorcontrib>Imamura, Masayuki</creatorcontrib><title>Augmented local immunity in the liver by a streptococcal preparation, OK432, related to antitumor activity of hepatic macrophages</title><title>Immunopharmacology</title><addtitle>Immunopharmacology</addtitle><description>The aim of this study was to investigate the augmentative effect of a streptoccal preparation, OK432, on the immunological competence of hepatic macrophages. We found that OK432 was distributed predominantly to hepatic macrophages after intravenous injection, and Northern blot analysis revealed that OK432 induced the gene expression of IL-1α, β, and TNFα in the liver. The induction of mRNAs was evident 1 h after the intravenous injection of OK432 and their accumulation reached a maximal level at 3 h. TNF production of hepatic macrophages was also increased by the intravenous injection of OK432. Furthermore, OK432 significantly increased the proportion of IL-2 receptor-positive hepatic macrophages. As for antitumor activity in the liver being augmented by OK432, the cytotoxic and cytostatic activity of hepatic macrophages from OK432-treated rats against tumor cells was significantly increased and OK432 markedly reduced the number of tumor nodules in the liver after the inoculation of tumor cells via the portal vein. These findings, which indicated that OK432 has various immuno-stimulating actions on hepatic macrophages, leading to the augmentation of antitumor activity in the liver, suggest that OK432 may be of some benefit in helping to prevent hepatic metastasis, at least in part, via its activation of hepatic macrophages.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Cytotoxicity, Immunologic - drug effects</subject><subject>Hepatic macrophage</subject><subject>Humans</subject><subject>IL-1αmRNA</subject><subject>IL-1βmRNA</subject><subject>IL-2 receptor</subject><subject>Immunotherapy</subject><subject>In Vitro Techniques</subject><subject>Interleukin-1 - biosynthesis</subject><subject>Liver - immunology</subject><subject>Liver - metabolism</subject><subject>Liver Neoplasms - immunology</subject><subject>Macrophage Activation - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>OK432</subject><subject>Pharmacology. Drug treatments</subject><subject>Picibanil - pharmacokinetics</subject><subject>Picibanil - pharmacology</subject><subject>Rats</subject><subject>Receptors, Interleukin-2 - biosynthesis</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Streptococcus</subject><subject>TNFαmRNA</subject><subject>Tumor Cells, Cultured</subject><subject>Tumor Necrosis Factor-alpha - biosynthesis</subject><issn>0162-3109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v3CAQhjm02m43_QeNxCGKGmndgsEfXCqtoiStGimX9owwjLNEtnEAr7TH_PPg7mqPyQEhZp55h3kHoa-UfKeElj_SyTNGifgm-JUghBQZ_YCWp_An9DmEpxTnlSgWaFHnpKyKfIleNtNjD0MEgzunVYdt30-DjXtsBxy3gDu7A4-bPVY4RA9jdNrpGRzTQ3kVrRvW-OEPZ_kae-jULBUdVkO0ceqdx0pHu5sVXYu3qSZajXulvRu36hHCGfrYqi7Al-O9Qv9ub_5e_8ruH-5-X2_uM81pFbOqLlnDBC10GiHngnHSmJZACczUBkzqT5u20aQ2NTdU10IZVRrRMtKCMZqt0OVBd_TueYIQZW-Dhq5TA7gpyKos8rwU9F2QlqIiXJAE8gOYZgnBQytHb3vl95ISOa9Fzv7L2X8puPy_Fjnrnx_1p6YHcyo67iTlL455FZLRrVeDtuGEMcETxxL284BBMm1nwcugLQwajPWgozTOvv2PV4-IrJU</recordid><startdate>199401</startdate><enddate>199401</enddate><creator>Mise, Masahiro</creator><creator>Arii, Shigeki</creator><creator>Higashitsuji, Hiroaki</creator><creator>Furutani, Masaharu</creator><creator>Monden, Kazunobu</creator><creator>Adachi, Yukito</creator><creator>Funaki, Naomi</creator><creator>Fujita, Shinichi</creator><creator>Ishiguro, Satoshi</creator><creator>Kitao, Tadahiro</creator><creator>Nakamura, Toshio</creator><creator>Fujita, Jun</creator><creator>Nakayama, Hiroki</creator><creator>Imamura, Masayuki</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>199401</creationdate><title>Augmented local immunity in the liver by a streptococcal preparation, OK432, related to antitumor activity of hepatic macrophages</title><author>Mise, Masahiro ; Arii, Shigeki ; Higashitsuji, Hiroaki ; Furutani, Masaharu ; Monden, Kazunobu ; Adachi, Yukito ; Funaki, Naomi ; Fujita, Shinichi ; Ishiguro, Satoshi ; Kitao, Tadahiro ; Nakamura, Toshio ; Fujita, Jun ; Nakayama, Hiroki ; Imamura, Masayuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-7863b3915c479249340bdf0e6e3d8ded4321bfbc08d84d1c89ada6d9f30feddc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Cytotoxicity, Immunologic - drug effects</topic><topic>Hepatic macrophage</topic><topic>Humans</topic><topic>IL-1αmRNA</topic><topic>IL-1βmRNA</topic><topic>IL-2 receptor</topic><topic>Immunotherapy</topic><topic>In Vitro Techniques</topic><topic>Interleukin-1 - biosynthesis</topic><topic>Liver - immunology</topic><topic>Liver - metabolism</topic><topic>Liver Neoplasms - immunology</topic><topic>Macrophage Activation - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>OK432</topic><topic>Pharmacology. Drug treatments</topic><topic>Picibanil - pharmacokinetics</topic><topic>Picibanil - pharmacology</topic><topic>Rats</topic><topic>Receptors, Interleukin-2 - biosynthesis</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Streptococcus</topic><topic>TNFαmRNA</topic><topic>Tumor Cells, Cultured</topic><topic>Tumor Necrosis Factor-alpha - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mise, Masahiro</creatorcontrib><creatorcontrib>Arii, Shigeki</creatorcontrib><creatorcontrib>Higashitsuji, Hiroaki</creatorcontrib><creatorcontrib>Furutani, Masaharu</creatorcontrib><creatorcontrib>Monden, Kazunobu</creatorcontrib><creatorcontrib>Adachi, Yukito</creatorcontrib><creatorcontrib>Funaki, Naomi</creatorcontrib><creatorcontrib>Fujita, Shinichi</creatorcontrib><creatorcontrib>Ishiguro, Satoshi</creatorcontrib><creatorcontrib>Kitao, Tadahiro</creatorcontrib><creatorcontrib>Nakamura, Toshio</creatorcontrib><creatorcontrib>Fujita, Jun</creatorcontrib><creatorcontrib>Nakayama, Hiroki</creatorcontrib><creatorcontrib>Imamura, Masayuki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mise, Masahiro</au><au>Arii, Shigeki</au><au>Higashitsuji, Hiroaki</au><au>Furutani, Masaharu</au><au>Monden, Kazunobu</au><au>Adachi, Yukito</au><au>Funaki, Naomi</au><au>Fujita, Shinichi</au><au>Ishiguro, Satoshi</au><au>Kitao, Tadahiro</au><au>Nakamura, Toshio</au><au>Fujita, Jun</au><au>Nakayama, Hiroki</au><au>Imamura, Masayuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Augmented local immunity in the liver by a streptococcal preparation, OK432, related to antitumor activity of hepatic macrophages</atitle><jtitle>Immunopharmacology</jtitle><addtitle>Immunopharmacology</addtitle><date>1994-01</date><risdate>1994</risdate><volume>27</volume><issue>1</issue><spage>31</spage><epage>41</epage><pages>31-41</pages><issn>0162-3109</issn><coden>IMMUDP</coden><abstract>The aim of this study was to investigate the augmentative effect of a streptoccal preparation, OK432, on the immunological competence of hepatic macrophages. We found that OK432 was distributed predominantly to hepatic macrophages after intravenous injection, and Northern blot analysis revealed that OK432 induced the gene expression of IL-1α, β, and TNFα in the liver. The induction of mRNAs was evident 1 h after the intravenous injection of OK432 and their accumulation reached a maximal level at 3 h. TNF production of hepatic macrophages was also increased by the intravenous injection of OK432. Furthermore, OK432 significantly increased the proportion of IL-2 receptor-positive hepatic macrophages. As for antitumor activity in the liver being augmented by OK432, the cytotoxic and cytostatic activity of hepatic macrophages from OK432-treated rats against tumor cells was significantly increased and OK432 markedly reduced the number of tumor nodules in the liver after the inoculation of tumor cells via the portal vein. These findings, which indicated that OK432 has various immuno-stimulating actions on hepatic macrophages, leading to the augmentation of antitumor activity in the liver, suggest that OK432 may be of some benefit in helping to prevent hepatic metastasis, at least in part, via its activation of hepatic macrophages.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>8206752</pmid><doi>10.1016/0162-3109(94)90005-1</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0162-3109 |
| ispartof | Immunopharmacology, 1994-01, Vol.27 (1), p.31-41 |
| issn | 0162-3109 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76522691 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Antineoplastic agents Biological and medical sciences Cytotoxicity, Immunologic - drug effects Hepatic macrophage Humans IL-1αmRNA IL-1βmRNA IL-2 receptor Immunotherapy In Vitro Techniques Interleukin-1 - biosynthesis Liver - immunology Liver - metabolism Liver Neoplasms - immunology Macrophage Activation - physiology Male Medical sciences OK432 Pharmacology. Drug treatments Picibanil - pharmacokinetics Picibanil - pharmacology Rats Receptors, Interleukin-2 - biosynthesis RNA, Messenger - biosynthesis Streptococcus TNFαmRNA Tumor Cells, Cultured Tumor Necrosis Factor-alpha - biosynthesis |
| title | Augmented local immunity in the liver by a streptococcal preparation, OK432, related to antitumor activity of hepatic macrophages |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T02%3A33%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Augmented%20local%20immunity%20in%20the%20liver%20by%20a%20streptococcal%20preparation,%20OK432,%20related%20to%20antitumor%20activity%20of%20hepatic%20macrophages&rft.jtitle=Immunopharmacology&rft.au=Mise,%20Masahiro&rft.date=1994-01&rft.volume=27&rft.issue=1&rft.spage=31&rft.epage=41&rft.pages=31-41&rft.issn=0162-3109&rft.coden=IMMUDP&rft_id=info:doi/10.1016/0162-3109(94)90005-1&rft_dat=%3Cproquest_cross%3E16970490%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16970490&rft_id=info:pmid/8206752&rft_els_id=0162310994900051&rfr_iscdi=true |