Physiological importance of dehydroepiandrosterone
Dehydroepiandrosterone (DHEA), with its sulphate conjugate (DHEAS), is the most abundant steroid hormone in the circulation but its physiological importance is unclear. We propose that DHEA has either oestrogen-like or androgen-like effects depending on the hormonal milieu. In premenopausal women DH...
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| Veröffentlicht in: | The Lancet (British edition) 1994-06, Vol.343 (8911), p.1479-1481 |
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| description | Dehydroepiandrosterone (DHEA), with its sulphate conjugate (DHEAS), is the most abundant steroid hormone in the circulation but its physiological importance is unclear. We propose that DHEA has either oestrogen-like or androgen-like effects depending on the hormonal milieu. In premenopausal women DHEA is either an oestrogen antagonist, perhaps through the competitive binding of its metabolite 5-androstene-3β,17β-diol (ADIOL) and oestradiol to the oestrogen receptor, or an androgen through its metabolism to androstenedione and testosterone. In women DHEA contributes to abdominal obesity and insulin resistance: in the premenopausal high oestrogen concentrations may counterbalance the androgenic effects of DHEA but in the postmenopausal metabolism to testosterone may increase the risk of cardiovascular disease, though this effect may be counterbalanced by the age-dependent decline in DHEA and also by the oestradiol-like effects of ADIOL. In some breast cancer cell lines in a low oestrogen milieu DHEA has an oestradiol-like effect, stimulating tumour growth, whereas in oestradiol abundance DHEA antagonises the growth-stimulating effect of oestradiol. In men, with an androgenic milieu, DHEA acts like an oestrogen and protects against cardiovascular disease. |
| doi_str_mv | 10.1016/S0140-6736(94)92587-9 |
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We propose that DHEA has either oestrogen-like or androgen-like effects depending on the hormonal milieu. In premenopausal women DHEA is either an oestrogen antagonist, perhaps through the competitive binding of its metabolite 5-androstene-3β,17β-diol (ADIOL) and oestradiol to the oestrogen receptor, or an androgen through its metabolism to androstenedione and testosterone. In women DHEA contributes to abdominal obesity and insulin resistance: in the premenopausal high oestrogen concentrations may counterbalance the androgenic effects of DHEA but in the postmenopausal metabolism to testosterone may increase the risk of cardiovascular disease, though this effect may be counterbalanced by the age-dependent decline in DHEA and also by the oestradiol-like effects of ADIOL. In some breast cancer cell lines in a low oestrogen milieu DHEA has an oestradiol-like effect, stimulating tumour growth, whereas in oestradiol abundance DHEA antagonises the growth-stimulating effect of oestradiol. In men, with an androgenic milieu, DHEA acts like an oestrogen and protects against cardiovascular disease.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(94)92587-9</identifier><identifier>PMID: 7911183</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Anatomy & physiology ; Androgens ; Biological and medical sciences ; Breast Neoplasms - metabolism ; Cardiovascular diseases ; Cardiovascular Diseases - blood ; Dehydroepiandrosterone - blood ; Dehydroepiandrosterone - physiology ; Estrogens ; Female ; Fundamental and applied biological sciences. Psychology ; Health risks ; Humans ; Insulin Resistance - physiology ; Male ; Medical research ; Menopause - metabolism ; Metabolites ; Obesity - metabolism ; Physiology ; Reference Values ; Steroid hormones. 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Jun 11, 1994</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-5754867ebf2d1d74c867fc200c184a005c6b6c322707f378490430b80a4fdcc3</citedby><cites>FETCH-LOGICAL-c482t-5754867ebf2d1d74c867fc200c184a005c6b6c322707f378490430b80a4fdcc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/199030358?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4146671$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7911183$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eberling, P.</creatorcontrib><creatorcontrib>Koivisto, V.A.</creatorcontrib><title>Physiological importance of dehydroepiandrosterone</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>Dehydroepiandrosterone (DHEA), with its sulphate conjugate (DHEAS), is the most abundant steroid hormone in the circulation but its physiological importance is unclear. We propose that DHEA has either oestrogen-like or androgen-like effects depending on the hormonal milieu. In premenopausal women DHEA is either an oestrogen antagonist, perhaps through the competitive binding of its metabolite 5-androstene-3β,17β-diol (ADIOL) and oestradiol to the oestrogen receptor, or an androgen through its metabolism to androstenedione and testosterone. In women DHEA contributes to abdominal obesity and insulin resistance: in the premenopausal high oestrogen concentrations may counterbalance the androgenic effects of DHEA but in the postmenopausal metabolism to testosterone may increase the risk of cardiovascular disease, though this effect may be counterbalanced by the age-dependent decline in DHEA and also by the oestradiol-like effects of ADIOL. In some breast cancer cell lines in a low oestrogen milieu DHEA has an oestradiol-like effect, stimulating tumour growth, whereas in oestradiol abundance DHEA antagonises the growth-stimulating effect of oestradiol. In men, with an androgenic milieu, DHEA acts like an oestrogen and protects against cardiovascular disease.</description><subject>Anatomy & physiology</subject><subject>Androgens</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - metabolism</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - blood</subject><subject>Dehydroepiandrosterone - blood</subject><subject>Dehydroepiandrosterone - physiology</subject><subject>Estrogens</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health risks</subject><subject>Humans</subject><subject>Insulin Resistance - physiology</subject><subject>Male</subject><subject>Medical research</subject><subject>Menopause - metabolism</subject><subject>Metabolites</subject><subject>Obesity - metabolism</subject><subject>Physiology</subject><subject>Reference Values</subject><subject>Steroid hormones. 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Psychology</topic><topic>Health risks</topic><topic>Humans</topic><topic>Insulin Resistance - physiology</topic><topic>Male</topic><topic>Medical research</topic><topic>Menopause - metabolism</topic><topic>Metabolites</topic><topic>Obesity - metabolism</topic><topic>Physiology</topic><topic>Reference Values</topic><topic>Steroid hormones. 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Academic</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eberling, P.</au><au>Koivisto, V.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physiological importance of dehydroepiandrosterone</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>1994-06-11</date><risdate>1994</risdate><volume>343</volume><issue>8911</issue><spage>1479</spage><epage>1481</epage><pages>1479-1481</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>Dehydroepiandrosterone (DHEA), with its sulphate conjugate (DHEAS), is the most abundant steroid hormone in the circulation but its physiological importance is unclear. We propose that DHEA has either oestrogen-like or androgen-like effects depending on the hormonal milieu. In premenopausal women DHEA is either an oestrogen antagonist, perhaps through the competitive binding of its metabolite 5-androstene-3β,17β-diol (ADIOL) and oestradiol to the oestrogen receptor, or an androgen through its metabolism to androstenedione and testosterone. In women DHEA contributes to abdominal obesity and insulin resistance: in the premenopausal high oestrogen concentrations may counterbalance the androgenic effects of DHEA but in the postmenopausal metabolism to testosterone may increase the risk of cardiovascular disease, though this effect may be counterbalanced by the age-dependent decline in DHEA and also by the oestradiol-like effects of ADIOL. In some breast cancer cell lines in a low oestrogen milieu DHEA has an oestradiol-like effect, stimulating tumour growth, whereas in oestradiol abundance DHEA antagonises the growth-stimulating effect of oestradiol. In men, with an androgenic milieu, DHEA acts like an oestrogen and protects against cardiovascular disease.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>7911183</pmid><doi>10.1016/S0140-6736(94)92587-9</doi><tpages>3</tpages></addata></record> |
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| subjects | Anatomy & physiology Androgens Biological and medical sciences Breast Neoplasms - metabolism Cardiovascular diseases Cardiovascular Diseases - blood Dehydroepiandrosterone - blood Dehydroepiandrosterone - physiology Estrogens Female Fundamental and applied biological sciences. Psychology Health risks Humans Insulin Resistance - physiology Male Medical research Menopause - metabolism Metabolites Obesity - metabolism Physiology Reference Values Steroid hormones. Cholecalciferol derivatives Steroids Vertebrates: endocrinology |
| title | Physiological importance of dehydroepiandrosterone |
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