On the change of cardiac action potential with age: a study in dogs
The action potential duration (APD) was measured using an Ag-AgCl electrode, in open chest anaesthetised dogs (n = 8) and puppies, 4 to 6 months old (n=8), with complete atrio-ventricular dissociation and β-adrenergic blockade. They were paced in the control period at a frequency of 120 beats·min−1....
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| Veröffentlicht in: | Cardiovascular research 1985-11, Vol.19 (11), p.674-678 |
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| container_title | Cardiovascular research |
| container_volume | 19 |
| creator | BOSKER, HANS DRAKE-HOLLAND, ANGELA J KEURS, HENK E D J TER NOBLE, MARK I M PASSINGHAM, JANE E PEPPER, JOHN R MAIN, MARK J WANLESS, RICHARD B |
| description | The action potential duration (APD) was measured using an Ag-AgCl electrode, in open chest anaesthetised dogs (n = 8) and puppies, 4 to 6 months old (n=8), with complete atrio-ventricular dissociation and β-adrenergic blockade. They were paced in the control period at a frequency of 120 beats·min−1. Both adults and puppies showed maximum action potential duration at a test pulse interval of over 700 ms. Below this the adult dogs showed a progressive shortening of the action potential duration (mean APD 81.5% at 200 ms). In contrast, the puppies showed much less shortening (91% at 200 ms; p |
| doi_str_mv | 10.1093/cvr/19.11.674 |
| format | Article |
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They were paced in the control period at a frequency of 120 beats·min−1. Both adults and puppies showed maximum action potential duration at a test pulse interval of over 700 ms. Below this the adult dogs showed a progressive shortening of the action potential duration (mean APD 81.5% at 200 ms). In contrast, the puppies showed much less shortening (91% at 200 ms; p<0.001). Measurements of Na+, K+-ATPase activity by the Rb uptake method gave values of 13.4± 1.3 (puppies, n = 4) and 6.1 ± 1.1 (adults, n = 6). These results may be consistent with the idea of a greater influx and efflux of sodium in the myocardial cells of the puppy compared with the adult dog.</description><identifier>ISSN: 0008-6363</identifier><identifier>EISSN: 1755-3245</identifier><identifier>DOI: 10.1093/cvr/19.11.674</identifier><identifier>PMID: 4075357</identifier><identifier>CODEN: CVREAU</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>action potential duration ; Action Potentials ; Aging ; Animals ; Biological and medical sciences ; Dogs ; Fundamental and applied biological sciences. Psychology ; Heart ; Heart - physiology ; puppy vs dog ; sodium pump ; Time Factors ; Vertebrates: cardiovascular system</subject><ispartof>Cardiovascular research, 1985-11, Vol.19 (11), p.674-678</ispartof><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-c99a5f856aa4c61d17cdc728997d735e9b463c5f95a0cfdc63863ccfe43e86393</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8696167$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4075357$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BOSKER, HANS</creatorcontrib><creatorcontrib>DRAKE-HOLLAND, ANGELA J</creatorcontrib><creatorcontrib>KEURS, HENK E D J TER</creatorcontrib><creatorcontrib>NOBLE, MARK I M</creatorcontrib><creatorcontrib>PASSINGHAM, JANE E</creatorcontrib><creatorcontrib>PEPPER, JOHN R</creatorcontrib><creatorcontrib>MAIN, MARK J</creatorcontrib><creatorcontrib>WANLESS, RICHARD B</creatorcontrib><title>On the change of cardiac action potential with age: a study in dogs</title><title>Cardiovascular research</title><addtitle>Cardiovasc Res</addtitle><description>The action potential duration (APD) was measured using an Ag-AgCl electrode, in open chest anaesthetised dogs (n = 8) and puppies, 4 to 6 months old (n=8), with complete atrio-ventricular dissociation and β-adrenergic blockade. They were paced in the control period at a frequency of 120 beats·min−1. Both adults and puppies showed maximum action potential duration at a test pulse interval of over 700 ms. Below this the adult dogs showed a progressive shortening of the action potential duration (mean APD 81.5% at 200 ms). In contrast, the puppies showed much less shortening (91% at 200 ms; p<0.001). Measurements of Na+, K+-ATPase activity by the Rb uptake method gave values of 13.4± 1.3 (puppies, n = 4) and 6.1 ± 1.1 (adults, n = 6). These results may be consistent with the idea of a greater influx and efflux of sodium in the myocardial cells of the puppy compared with the adult dog.</description><subject>action potential duration</subject><subject>Action Potentials</subject><subject>Aging</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Dogs</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart</subject><subject>Heart - physiology</subject><subject>puppy vs dog</subject><subject>sodium pump</subject><subject>Time Factors</subject><subject>Vertebrates: cardiovascular system</subject><issn>0008-6363</issn><issn>1755-3245</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1PGzEQxa2qCALl2COSDxW3Det4x1731kZ8tCByaaWKizXMehPDZje1HSD_PUZE4TTz9H56T3qMfRXlWJRGntFTOBNmLMRY6eoTGwkNUMhJBZ_ZqCzLulBSyQN2GONDlgC62mf7ValBgh6x6aznaeE4LbCfOz60nDA0HokjJT_0fDUk1yePHX_2acFx7r5z5DGtmw33PW-GefzC9lrsojve3iP29-L8z_SquJld_pr-uCmomkAqyBiEtgaFWJESjdDUkJ7UxuhGS3DmvlKSoDWAJbUNKVlnTa2rpMufkUfs9D13FYb_axeTXfpIruuwd8M6Wq1AaKXqDBbvIIUhxuBauwp-iWFjRWnfRrN5NCuMFcLm0TJ_sg1e3y9ds6O3K2X_29bHSNi1AXvycYfVyiih9Eetj8m97GwMj7lFarBX_-7stZjArYDf9qd8BSUEgok</recordid><startdate>198511</startdate><enddate>198511</enddate><creator>BOSKER, HANS</creator><creator>DRAKE-HOLLAND, ANGELA J</creator><creator>KEURS, HENK E D J TER</creator><creator>NOBLE, MARK I M</creator><creator>PASSINGHAM, JANE E</creator><creator>PEPPER, JOHN R</creator><creator>MAIN, MARK J</creator><creator>WANLESS, RICHARD B</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198511</creationdate><title>On the change of cardiac action potential with age: a study in dogs</title><author>BOSKER, HANS ; DRAKE-HOLLAND, ANGELA J ; KEURS, HENK E D J TER ; NOBLE, MARK I M ; PASSINGHAM, JANE E ; PEPPER, JOHN R ; MAIN, MARK J ; WANLESS, RICHARD B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-c99a5f856aa4c61d17cdc728997d735e9b463c5f95a0cfdc63863ccfe43e86393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>action potential duration</topic><topic>Action Potentials</topic><topic>Aging</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Dogs</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart</topic><topic>Heart - physiology</topic><topic>puppy vs dog</topic><topic>sodium pump</topic><topic>Time Factors</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BOSKER, HANS</creatorcontrib><creatorcontrib>DRAKE-HOLLAND, ANGELA J</creatorcontrib><creatorcontrib>KEURS, HENK E D J TER</creatorcontrib><creatorcontrib>NOBLE, MARK I M</creatorcontrib><creatorcontrib>PASSINGHAM, JANE E</creatorcontrib><creatorcontrib>PEPPER, JOHN R</creatorcontrib><creatorcontrib>MAIN, MARK J</creatorcontrib><creatorcontrib>WANLESS, RICHARD B</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiovascular research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BOSKER, HANS</au><au>DRAKE-HOLLAND, ANGELA J</au><au>KEURS, HENK E D J TER</au><au>NOBLE, MARK I M</au><au>PASSINGHAM, JANE E</au><au>PEPPER, JOHN R</au><au>MAIN, MARK J</au><au>WANLESS, RICHARD B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>On the change of cardiac action potential with age: a study in dogs</atitle><jtitle>Cardiovascular research</jtitle><addtitle>Cardiovasc Res</addtitle><date>1985-11</date><risdate>1985</risdate><volume>19</volume><issue>11</issue><spage>674</spage><epage>678</epage><pages>674-678</pages><issn>0008-6363</issn><eissn>1755-3245</eissn><coden>CVREAU</coden><abstract>The action potential duration (APD) was measured using an Ag-AgCl electrode, in open chest anaesthetised dogs (n = 8) and puppies, 4 to 6 months old (n=8), with complete atrio-ventricular dissociation and β-adrenergic blockade. They were paced in the control period at a frequency of 120 beats·min−1. Both adults and puppies showed maximum action potential duration at a test pulse interval of over 700 ms. Below this the adult dogs showed a progressive shortening of the action potential duration (mean APD 81.5% at 200 ms). In contrast, the puppies showed much less shortening (91% at 200 ms; p<0.001). Measurements of Na+, K+-ATPase activity by the Rb uptake method gave values of 13.4± 1.3 (puppies, n = 4) and 6.1 ± 1.1 (adults, n = 6). These results may be consistent with the idea of a greater influx and efflux of sodium in the myocardial cells of the puppy compared with the adult dog.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>4075357</pmid><doi>10.1093/cvr/19.11.674</doi><tpages>5</tpages></addata></record> |
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| ispartof | Cardiovascular research, 1985-11, Vol.19 (11), p.674-678 |
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| source | Oxford University Press Journals Digital Archive legacy; MEDLINE |
| subjects | action potential duration Action Potentials Aging Animals Biological and medical sciences Dogs Fundamental and applied biological sciences. Psychology Heart Heart - physiology puppy vs dog sodium pump Time Factors Vertebrates: cardiovascular system |
| title | On the change of cardiac action potential with age: a study in dogs |
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