Effects of glucagon on urinary excretion of urea and on plasma ammonia level in argininosuccinate synthetase deficiency

Glucagon, a potent inducer of urea cycle enzymes, was administered subcutaneously, at a dose of 0.5 mg once a day, for 7 days to two citrullinemic patients. During this period, plasma NH3 levels in case 1 decreased significantly (P < 0.05 compared to levels before administration) and daily urinar...

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Veröffentlicht in:	Journal of gastroenterology 1994-02, Vol.29 (1), p.31-34
Hauptverfasser:	Tamura, S, Kawata, S, Fukuda, K, Inui, Y, Kakimoto, H, Ishiguro, H, Namba, M, Kono, N, Matsuzawa, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino Acid Metabolism, Inborn Errors - drug therapy Amino Acid Metabolism, Inborn Errors - metabolism Ammonia - blood Argininosuccinate Synthase - deficiency Citrulline - blood Female Glucagon - therapeutic use Humans Male Urea - urine
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