Serum interleukin-6 concentration in schizophrenia: Elevation associated with duration of illness
Using an enzyme immunoassay (ELISA), we measured serum interleukin-6 (IL-6) concentration in 128 schizophrenic patients (24 of whom were never medicated) and in 110 normal control subjects. Mean serum IL-6 concentration was significantly higher in the schizophrenic patients as compared with the cont...
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| Veröffentlicht in: | Psychiatry research 1994, Vol.51 (1), p.1-10 |
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| container_title | Psychiatry research |
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| creator | Ganguli, Rohan Yang, Zanwei Shurin, Galina Chengappa, K.N.Roy Brar, Jaspreet S. Gubbi, Amanda V. Rabin, Bruce S. |
| description | Using an enzyme immunoassay (ELISA), we measured serum interleukin-6 (IL-6) concentration in 128 schizophrenic patients (24 of whom were never medicated) and in 110 normal control subjects. Mean serum IL-6 concentration was significantly higher in the schizophrenic patients as compared with the control subjects (
p = 0.009). Comparisons within the patient group revealed that serum IL-6 was significantly correlated with duration of illness (
r = 0.32,
p = 0.0004). After covariation for duration of illness, there was no relationship between IL-6 levels and the production of autoantibodies, clinical state, or medication status. Thus, elevated serum IL-6 levels in schizophrenia develop during the course of illness and may be related to treatment or to disease progression. |
| doi_str_mv | 10.1016/0165-1781(94)90042-6 |
| format | Article |
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p = 0.009). Comparisons within the patient group revealed that serum IL-6 was significantly correlated with duration of illness (
r = 0.32,
p = 0.0004). After covariation for duration of illness, there was no relationship between IL-6 levels and the production of autoantibodies, clinical state, or medication status. Thus, elevated serum IL-6 levels in schizophrenia develop during the course of illness and may be related to treatment or to disease progression.</description><identifier>ISSN: 0165-1781</identifier><identifier>EISSN: 1872-7123</identifier><identifier>DOI: 10.1016/0165-1781(94)90042-6</identifier><identifier>PMID: 7910974</identifier><identifier>CODEN: PSRSDR</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Adult and adolescent clinical studies ; Antipsychotic Agents - administration & dosage ; Antipsychotic Agents - therapeutic use ; Autoantibodies ; Autoantibodies - immunology ; Biological and medical sciences ; cytokine ; Cytokines - immunology ; Ethnic Groups ; Female ; Humans ; Interleukin-6 - blood ; Interleukin-6 - immunology ; Male ; Medical sciences ; psychoimmunology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Schizophrenia ; Schizophrenia - blood ; Schizophrenia - drug therapy ; Schizophrenia - immunology ; Sex Factors</subject><ispartof>Psychiatry research, 1994, Vol.51 (1), p.1-10</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-f0d2dbd39723c2a2c77e1271357447f186231f37313245de03a3f6d220bd0f253</citedby><cites>FETCH-LOGICAL-c386t-f0d2dbd39723c2a2c77e1271357447f186231f37313245de03a3f6d220bd0f253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0165-1781(94)90042-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3917443$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7910974$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ganguli, Rohan</creatorcontrib><creatorcontrib>Yang, Zanwei</creatorcontrib><creatorcontrib>Shurin, Galina</creatorcontrib><creatorcontrib>Chengappa, K.N.Roy</creatorcontrib><creatorcontrib>Brar, Jaspreet S.</creatorcontrib><creatorcontrib>Gubbi, Amanda V.</creatorcontrib><creatorcontrib>Rabin, Bruce S.</creatorcontrib><title>Serum interleukin-6 concentration in schizophrenia: Elevation associated with duration of illness</title><title>Psychiatry research</title><addtitle>Psychiatry Res</addtitle><description>Using an enzyme immunoassay (ELISA), we measured serum interleukin-6 (IL-6) concentration in 128 schizophrenic patients (24 of whom were never medicated) and in 110 normal control subjects. Mean serum IL-6 concentration was significantly higher in the schizophrenic patients as compared with the control subjects (
p = 0.009). Comparisons within the patient group revealed that serum IL-6 was significantly correlated with duration of illness (
r = 0.32,
p = 0.0004). After covariation for duration of illness, there was no relationship between IL-6 levels and the production of autoantibodies, clinical state, or medication status. Thus, elevated serum IL-6 levels in schizophrenia develop during the course of illness and may be related to treatment or to disease progression.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Antipsychotic Agents - administration & dosage</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Autoantibodies</subject><subject>Autoantibodies - immunology</subject><subject>Biological and medical sciences</subject><subject>cytokine</subject><subject>Cytokines - immunology</subject><subject>Ethnic Groups</subject><subject>Female</subject><subject>Humans</subject><subject>Interleukin-6 - blood</subject><subject>Interleukin-6 - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>psychoimmunology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Schizophrenia</subject><subject>Schizophrenia - blood</subject><subject>Schizophrenia - drug therapy</subject><subject>Schizophrenia - immunology</subject><subject>Sex Factors</subject><issn>0165-1781</issn><issn>1872-7123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFOGzEQhq0KBIHyBiDtAVX0sNRj765jDpUqlEIlpB5azpZjjxXDxg72LhV9-jrNKkcOIx_-7x-NP0LOgV4Dhe5LmbYGMYcr2XyWlDas7j6QGcwFqwUwfkBme-SYnOT8RCllIOURORISqBTNjOhfmMZ15cOAqcfx2Ye6q0wMBsOQ9OBjKFmVzcr_jZtVwuD1TbXo8XWX6Zyj8XpAW_3xw6qy41SKrvJ9HzDnj-TQ6T7j2fSeksfvi9-39_XDz7sft98easPn3VA7apldWi4F44ZpZoRAYAJ4K5pGOJh3jIPjggNnTWuRcs1dZxmjS0sda_kp-bTbu0nxZcQ8qLXPBvteB4xjVqJroZWMFrDZgSbFnBM6tUl-rdObAqq2ZtVWm9pqU7JR_82qrtQupv3jco12X5pUlvxyynU2undJB-PzHuMSykd4wb7uMCwuXj0mlY3H4tv6hGZQNvr37_gHxJuUuw</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>Ganguli, Rohan</creator><creator>Yang, Zanwei</creator><creator>Shurin, Galina</creator><creator>Chengappa, K.N.Roy</creator><creator>Brar, Jaspreet S.</creator><creator>Gubbi, Amanda V.</creator><creator>Rabin, Bruce S.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1994</creationdate><title>Serum interleukin-6 concentration in schizophrenia: Elevation associated with duration of illness</title><author>Ganguli, Rohan ; Yang, Zanwei ; Shurin, Galina ; Chengappa, K.N.Roy ; Brar, Jaspreet S. ; Gubbi, Amanda V. ; Rabin, Bruce S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-f0d2dbd39723c2a2c77e1271357447f186231f37313245de03a3f6d220bd0f253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Antipsychotic Agents - administration & dosage</topic><topic>Antipsychotic Agents - therapeutic use</topic><topic>Autoantibodies</topic><topic>Autoantibodies - immunology</topic><topic>Biological and medical sciences</topic><topic>cytokine</topic><topic>Cytokines - immunology</topic><topic>Ethnic Groups</topic><topic>Female</topic><topic>Humans</topic><topic>Interleukin-6 - blood</topic><topic>Interleukin-6 - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>psychoimmunology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Schizophrenia</topic><topic>Schizophrenia - blood</topic><topic>Schizophrenia - drug therapy</topic><topic>Schizophrenia - immunology</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ganguli, Rohan</creatorcontrib><creatorcontrib>Yang, Zanwei</creatorcontrib><creatorcontrib>Shurin, Galina</creatorcontrib><creatorcontrib>Chengappa, K.N.Roy</creatorcontrib><creatorcontrib>Brar, Jaspreet S.</creatorcontrib><creatorcontrib>Gubbi, Amanda V.</creatorcontrib><creatorcontrib>Rabin, Bruce S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ganguli, Rohan</au><au>Yang, Zanwei</au><au>Shurin, Galina</au><au>Chengappa, K.N.Roy</au><au>Brar, Jaspreet S.</au><au>Gubbi, Amanda V.</au><au>Rabin, Bruce S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum interleukin-6 concentration in schizophrenia: Elevation associated with duration of illness</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>1994</date><risdate>1994</risdate><volume>51</volume><issue>1</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>0165-1781</issn><eissn>1872-7123</eissn><coden>PSRSDR</coden><abstract>Using an enzyme immunoassay (ELISA), we measured serum interleukin-6 (IL-6) concentration in 128 schizophrenic patients (24 of whom were never medicated) and in 110 normal control subjects. Mean serum IL-6 concentration was significantly higher in the schizophrenic patients as compared with the control subjects (
p = 0.009). Comparisons within the patient group revealed that serum IL-6 was significantly correlated with duration of illness (
r = 0.32,
p = 0.0004). After covariation for duration of illness, there was no relationship between IL-6 levels and the production of autoantibodies, clinical state, or medication status. Thus, elevated serum IL-6 levels in schizophrenia develop during the course of illness and may be related to treatment or to disease progression.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>7910974</pmid><doi>10.1016/0165-1781(94)90042-6</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Adult and adolescent clinical studies Antipsychotic Agents - administration & dosage Antipsychotic Agents - therapeutic use Autoantibodies Autoantibodies - immunology Biological and medical sciences cytokine Cytokines - immunology Ethnic Groups Female Humans Interleukin-6 - blood Interleukin-6 - immunology Male Medical sciences psychoimmunology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - blood Schizophrenia - drug therapy Schizophrenia - immunology Sex Factors |
| title | Serum interleukin-6 concentration in schizophrenia: Elevation associated with duration of illness |
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