Satellite cell activity is required for hypertrophy of overloaded adult rat muscle
Hypertrophy of extensor digitorum longus muscle, overloaded by the removal of the synergist tibialis anterior (TA) muscle, in growing rats is inhibited if endogenous satellite cells are sterilized by exposure to irradiation. However, normal muscle growth is not eliminated, only diminished. To test w...
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| Veröffentlicht in: | Muscle & nerve 1994-06, Vol.17 (6), p.608-613 |
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| creator | Rosenblatt, J. David Yong, David Parry, David J. |
| description | Hypertrophy of extensor digitorum longus muscle, overloaded by the removal of the synergist tibialis anterior (TA) muscle, in growing rats is inhibited if endogenous satellite cells are sterilized by exposure to irradiation. However, normal muscle growth is not eliminated, only diminished. To test whether irradiated, overloaded muscle can hypertrophy in the absence of normal growth‐related stimuli, experiments were conducted on mature rats. TA muscle ablation caused hypertrophy of EDL muscle, characterized by a significant increase in muscle mass and the size of type IIx and type IIb fibers, and a proportional increase the number of myonuclei. When ablation was preceded by irradiation hypertrophy did not occur. The results indicate that satellite cell activation, division, and fusion is necessary for compensatory hypertrophy of fully mature muscle, and may be important to the understanding of the limits of recovery of inherited muscle myopathies treated by myogenic cell implantation. © 1994 John Wiley & Sons, Inc. |
| doi_str_mv | 10.1002/mus.880170607 |
| format | Article |
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David ; Yong, David ; Parry, David J.</creator><creatorcontrib>Rosenblatt, J. David ; Yong, David ; Parry, David J.</creatorcontrib><description>Hypertrophy of extensor digitorum longus muscle, overloaded by the removal of the synergist tibialis anterior (TA) muscle, in growing rats is inhibited if endogenous satellite cells are sterilized by exposure to irradiation. However, normal muscle growth is not eliminated, only diminished. To test whether irradiated, overloaded muscle can hypertrophy in the absence of normal growth‐related stimuli, experiments were conducted on mature rats. TA muscle ablation caused hypertrophy of EDL muscle, characterized by a significant increase in muscle mass and the size of type IIx and type IIb fibers, and a proportional increase the number of myonuclei. When ablation was preceded by irradiation hypertrophy did not occur. The results indicate that satellite cell activation, division, and fusion is necessary for compensatory hypertrophy of fully mature muscle, and may be important to the understanding of the limits of recovery of inherited muscle myopathies treated by myogenic cell implantation. © 1994 John Wiley & Sons, Inc.</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.880170607</identifier><identifier>PMID: 8196703</identifier><identifier>CODEN: MUNEDE</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adaptation, Physiological ; Animals ; Biological and medical sciences ; Fundamental and applied biological sciences. 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David</creatorcontrib><creatorcontrib>Yong, David</creatorcontrib><creatorcontrib>Parry, David J.</creatorcontrib><title>Satellite cell activity is required for hypertrophy of overloaded adult rat muscle</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>Hypertrophy of extensor digitorum longus muscle, overloaded by the removal of the synergist tibialis anterior (TA) muscle, in growing rats is inhibited if endogenous satellite cells are sterilized by exposure to irradiation. However, normal muscle growth is not eliminated, only diminished. To test whether irradiated, overloaded muscle can hypertrophy in the absence of normal growth‐related stimuli, experiments were conducted on mature rats. TA muscle ablation caused hypertrophy of EDL muscle, characterized by a significant increase in muscle mass and the size of type IIx and type IIb fibers, and a proportional increase the number of myonuclei. When ablation was preceded by irradiation hypertrophy did not occur. The results indicate that satellite cell activation, division, and fusion is necessary for compensatory hypertrophy of fully mature muscle, and may be important to the understanding of the limits of recovery of inherited muscle myopathies treated by myogenic cell implantation. © 1994 John Wiley & Sons, Inc.</description><subject>Adaptation, Physiological</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypertrophy</subject><subject>irradiation</subject><subject>Male</subject><subject>Muscle Development</subject><subject>muscle growth</subject><subject>Muscles - pathology</subject><subject>Muscles - radiation effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>satellite cells</subject><subject>skeletal muscle</subject><subject>Space life sciences</subject><subject>Striated muscle. Tendons</subject><subject>Toes</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1vFDEURS0ECptASYnkAtFNsMffJUpgQQogESLSWV77WTHMZja2J2T-PY52tKKiesU97_n4IvSKklNKSP9uO5VTrQlVRBL1BK0oMarjwuinaEUo151k5vo5Oi7lFyGEaqmO0JGmRirCVuj7paswDKkC9m1i52u6T3XGqeAMd1PKEHAcM76Zd5BrHnc3Mx4jHu8hD6MLLXVhGirOruKm4gd4gZ5FNxR4ucwTdPXxw4-zT93Ft_Xns_cXneeyKUbdC8k09CJSFcAYiLxnWgYg2ijBBOs3ZhNcjDQwIWTPnVMieBF19IpzdoLe7u_u8ng3Qal2m8rjJ9wtjFOxSgpKuSAN7Pagz2MpGaLd5bR1ebaU2McObRO3hw4b_3o5PG22EA70UlrL3yy5K94NMbtbn8oB45Qow_qGqT32Jw0w__9N--Xq8l-BRTiVCg-HTZd_W6mYEvbn17Wl2pxfr9sqYX8BHtGZgQ</recordid><startdate>199406</startdate><enddate>199406</enddate><creator>Rosenblatt, J. 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David ; Yong, David ; Parry, David J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4697-f825638e25f17de99ef42386de089753532b9bdaff1d355624aa75dc5f8fc7443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adaptation, Physiological</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypertrophy</topic><topic>irradiation</topic><topic>Male</topic><topic>Muscle Development</topic><topic>muscle growth</topic><topic>Muscles - pathology</topic><topic>Muscles - radiation effects</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>satellite cells</topic><topic>skeletal muscle</topic><topic>Space life sciences</topic><topic>Striated muscle. Tendons</topic><topic>Toes</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosenblatt, J. David</creatorcontrib><creatorcontrib>Yong, David</creatorcontrib><creatorcontrib>Parry, David J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosenblatt, J. David</au><au>Yong, David</au><au>Parry, David J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Satellite cell activity is required for hypertrophy of overloaded adult rat muscle</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>1994-06</date><risdate>1994</risdate><volume>17</volume><issue>6</issue><spage>608</spage><epage>613</epage><pages>608-613</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><coden>MUNEDE</coden><abstract>Hypertrophy of extensor digitorum longus muscle, overloaded by the removal of the synergist tibialis anterior (TA) muscle, in growing rats is inhibited if endogenous satellite cells are sterilized by exposure to irradiation. However, normal muscle growth is not eliminated, only diminished. To test whether irradiated, overloaded muscle can hypertrophy in the absence of normal growth‐related stimuli, experiments were conducted on mature rats. TA muscle ablation caused hypertrophy of EDL muscle, characterized by a significant increase in muscle mass and the size of type IIx and type IIb fibers, and a proportional increase the number of myonuclei. When ablation was preceded by irradiation hypertrophy did not occur. The results indicate that satellite cell activation, division, and fusion is necessary for compensatory hypertrophy of fully mature muscle, and may be important to the understanding of the limits of recovery of inherited muscle myopathies treated by myogenic cell implantation. © 1994 John Wiley & Sons, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8196703</pmid><doi>10.1002/mus.880170607</doi><tpages>6</tpages></addata></record> |
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| ispartof | Muscle & nerve, 1994-06, Vol.17 (6), p.608-613 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adaptation, Physiological Animals Biological and medical sciences Fundamental and applied biological sciences. Psychology Hypertrophy irradiation Male Muscle Development muscle growth Muscles - pathology Muscles - radiation effects Rats Rats, Sprague-Dawley satellite cells skeletal muscle Space life sciences Striated muscle. Tendons Toes Vertebrates: osteoarticular system, musculoskeletal system |
| title | Satellite cell activity is required for hypertrophy of overloaded adult rat muscle |
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