Synthesis, characterization, and anorectic testing of the four stereoisomers of cyclo(histidylproline)

All four possible stereoisomers of cyclo(histidylproline) were individually synthesized, purified, and characterized. They were each tested for anorectic activity in rats with a free feeding paradigm over 24 h. Contrary to literature reports, none significantly reduced food intake at any time over t...

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Veröffentlicht in:	Journal of medicinal chemistry 1985-11, Vol.28 (11), p.1745-1747
Hauptverfasser:	Kukla, Michael J, Breslin, Henry J, Bowden, Charles R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bombesin - pharmacology Chemical Phenomena Chemistry Eating - drug effects Exact sciences and technology Kinetics Male Organic chemistry Peptides Peptides, Cyclic - chemical synthesis Peptides, Cyclic - pharmacology Piperazines - chemical synthesis Piperazines - pharmacology Preparations and properties Rats Rats, Inbred Strains Stereoisomerism
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Zusammenfassung:	All four possible stereoisomers of cyclo(histidylproline) were individually synthesized, purified, and characterized. They were each tested for anorectic activity in rats with a free feeding paradigm over 24 h. Contrary to literature reports, none significantly reduced food intake at any time over the test period.
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm00149a035