Sensitivity of ortho- and paramyxovirus replication to human interferon α
Replication of the influenza virus strains Influenza Ao/WSN (H0N1), fowl plague (Hav1N1) and B-Lee/40 (ATCC) and the paramyxovirus, New Castle disease virus (Victoria) are highly sensitive to human interferon type alpha in Madin Darby bovine kidney cells. Pretreatment of cells with human interferon...
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| Veröffentlicht in: | Molecular biology reports 1985-10, Vol.10 (4), p.237-243 |
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| creator | STRUBE, M BODO, G JUNGWIRTH, C |
| description | Replication of the influenza virus strains Influenza Ao/WSN (H0N1), fowl plague (Hav1N1) and B-Lee/40 (ATCC) and the paramyxovirus, New Castle disease virus (Victoria) are highly sensitive to human interferon type alpha in Madin Darby bovine kidney cells. Pretreatment of cells with human interferon type alpha resulted in protection of the cells against viral cytopathic effect. The inhibition of the orthomyxovirus strains used in this study and New Castle disease virus replication is mediated by an inhibition of viral protein synthesis. Residual WSN virus particles released from interferon treated cells showed the same structural protein pattern as virus particles isolated from control cells. Glycosylation of the viral structural components appeared to be unaffected by interferon. |
| doi_str_mv | 10.1007/BF00775982 |
| format | Article |
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Pretreatment of cells with human interferon type alpha resulted in protection of the cells against viral cytopathic effect. The inhibition of the orthomyxovirus strains used in this study and New Castle disease virus replication is mediated by an inhibition of viral protein synthesis. Residual WSN virus particles released from interferon treated cells showed the same structural protein pattern as virus particles isolated from control cells. Glycosylation of the viral structural components appeared to be unaffected by interferon.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/BF00775982</identifier><identifier>PMID: 4069110</identifier><language>eng</language><publisher>Dordrecht: Kluwer</publisher><subject>Analysis of the immune response. Humoral and cellular immunity ; Animals ; Biological and medical sciences ; Cattle ; DNA Replication - drug effects ; Dogs ; Fundamental and applied biological sciences. 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Pretreatment of cells with human interferon type alpha resulted in protection of the cells against viral cytopathic effect. The inhibition of the orthomyxovirus strains used in this study and New Castle disease virus replication is mediated by an inhibition of viral protein synthesis. Residual WSN virus particles released from interferon treated cells showed the same structural protein pattern as virus particles isolated from control cells. Glycosylation of the viral structural components appeared to be unaffected by interferon.</description><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>DNA Replication - drug effects</subject><subject>Dogs</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>Influenza A virus - drug effects</subject><subject>Influenza B virus - drug effects</subject><subject>Interferon Type I - pharmacology</subject><subject>Kinetics</subject><subject>Mice</subject><subject>Miscellaneous</subject><subject>Newcastle disease virus - drug effects</subject><subject>Newcastle disease virus - genetics</subject><subject>Orthomyxoviridae - drug effects</subject><subject>Orthomyxoviridae - genetics</subject><subject>Regulatory factors and their cellular receptors</subject><subject>Species Specificity</subject><subject>Structure-Activity Relationship</subject><subject>Virus Replication - drug effects</subject><issn>0301-4851</issn><issn>1573-4978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM1KxDAURoMo4zi6cS9kIS6EapI2TbrUwfGHARfquty0CRNpmzFJB-exfBGfyYpl3NwL9zt8cA9Cp5RcUULE9e1imIIXku2hKeUiTbJCyH00JSmhSSY5PURHIbwTQjIq-ARNMpIXlJIpenrRXbDRbmzcYmew83HlEgxdjdfgod1-uo31fcBerxtbQbSuw9HhVd9Ch20XtTfaD7fvr2N0YKAJ-mTcM_S2uHudPyTL5_vH-c0yqRjLY6I4F4xyLjNgXBlulOK04DQHLQkrtKxBMqqBGVGAInWmoBaMaS5qBayGdIYu_nrX3n30OsSytaHSTQOddn0oRT58n1I2gJd_YOVdCF6bcu1tC35bUlL-iiv_xQ3w2djaq1bXO3Q0NeTnYw6hgsZ46CobdpgUGRNUpj8zCHYO</recordid><startdate>198510</startdate><enddate>198510</enddate><creator>STRUBE, M</creator><creator>BODO, G</creator><creator>JUNGWIRTH, C</creator><general>Kluwer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198510</creationdate><title>Sensitivity of ortho- and paramyxovirus replication to human interferon α</title><author>STRUBE, M ; BODO, G ; JUNGWIRTH, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c226t-b557215584a25bf5fbb519516ae8029e8da821ea2f79ab0d4bad722e57dba2da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>DNA Replication - drug effects</topic><topic>Dogs</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>Influenza A virus - drug effects</topic><topic>Influenza B virus - drug effects</topic><topic>Interferon Type I - pharmacology</topic><topic>Kinetics</topic><topic>Mice</topic><topic>Miscellaneous</topic><topic>Newcastle disease virus - drug effects</topic><topic>Newcastle disease virus - genetics</topic><topic>Orthomyxoviridae - drug effects</topic><topic>Orthomyxoviridae - genetics</topic><topic>Regulatory factors and their cellular receptors</topic><topic>Species Specificity</topic><topic>Structure-Activity Relationship</topic><topic>Virus Replication - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>STRUBE, M</creatorcontrib><creatorcontrib>BODO, G</creatorcontrib><creatorcontrib>JUNGWIRTH, C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular biology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>STRUBE, M</au><au>BODO, G</au><au>JUNGWIRTH, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sensitivity of ortho- and paramyxovirus replication to human interferon α</atitle><jtitle>Molecular biology reports</jtitle><addtitle>Mol Biol Rep</addtitle><date>1985-10</date><risdate>1985</risdate><volume>10</volume><issue>4</issue><spage>237</spage><epage>243</epage><pages>237-243</pages><issn>0301-4851</issn><eissn>1573-4978</eissn><abstract>Replication of the influenza virus strains Influenza Ao/WSN (H0N1), fowl plague (Hav1N1) and B-Lee/40 (ATCC) and the paramyxovirus, New Castle disease virus (Victoria) are highly sensitive to human interferon type alpha in Madin Darby bovine kidney cells. Pretreatment of cells with human interferon type alpha resulted in protection of the cells against viral cytopathic effect. The inhibition of the orthomyxovirus strains used in this study and New Castle disease virus replication is mediated by an inhibition of viral protein synthesis. Residual WSN virus particles released from interferon treated cells showed the same structural protein pattern as virus particles isolated from control cells. Glycosylation of the viral structural components appeared to be unaffected by interferon.</abstract><cop>Dordrecht</cop><pub>Kluwer</pub><pmid>4069110</pmid><doi>10.1007/BF00775982</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0301-4851 |
| ispartof | Molecular biology reports, 1985-10, Vol.10 (4), p.237-243 |
| issn | 0301-4851 1573-4978 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Analysis of the immune response. Humoral and cellular immunity Animals Biological and medical sciences Cattle DNA Replication - drug effects Dogs Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Influenza A virus - drug effects Influenza B virus - drug effects Interferon Type I - pharmacology Kinetics Mice Miscellaneous Newcastle disease virus - drug effects Newcastle disease virus - genetics Orthomyxoviridae - drug effects Orthomyxoviridae - genetics Regulatory factors and their cellular receptors Species Specificity Structure-Activity Relationship Virus Replication - drug effects |
| title | Sensitivity of ortho- and paramyxovirus replication to human interferon α |
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