beta.-Adrenoceptor activity of the stereoisomers of the bufuralol alcohol and ketone metabolites

The stereoisomers of 2-[(tert-butylamino)methyl]-7-methyl-2,7-benzofurandimethanol (2) and 2-[2-(tert-butylamino)-1-hydroxyethyl]-7-benzofuranyl methyl ketone (3), the alcohol and ketone metabolites of bufuralol, have been prepared and examined for beta-adrenoceptor activity in rats. All the stereoi...

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Veröffentlicht in:	Journal of medicinal chemistry 1985-11, Vol.28 (11), p.1648-1651
Hauptverfasser:	Machin, Peter J, Hurst, David N, Osbond, John M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - pharmacology Animals Blood Pressure - drug effects Chemical Phenomena Chemistry Ethanolamines - chemical synthesis Ethanolamines - pharmacology Exact sciences and technology Heart Rate - drug effects Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives Isoproterenol - pharmacology Molecular Conformation Organic chemistry Preparations and properties Rats Receptors, Adrenergic, beta - drug effects Receptors, Adrenergic, beta - physiology Stereoisomerism Structure-Activity Relationship
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