TISSUE DISTRIBUTION OF CEFMINOX IN BEAGLE DOGS

A new cephamycin antibiotic, cefminox (MT-141, CMNX), was intravenously infused into Beagle dogs at a dose of 40 mg/kg in order to study it's distribution to various tissues. The following results were obtained. 1. The maximum serum concentration of CMNX observed at the end of the infusion peri...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Japanese journal of antibiotics 1985/07/25, Vol.38(7), pp.1769-1775
Hauptverfasser: CHIBA, FUMIKO, KOMIYA, IZUMI, FUJITA, MASATAKA, SHINKAI, SACHIHIKO, SAKURAI, TAKASHI, NAKAYOSHI, TAKEMI
Format: Artikel
Sprache:jpn
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1775
container_issue 7
container_start_page 1769
container_title Japanese journal of antibiotics
container_volume 38
creator CHIBA, FUMIKO
KOMIYA, IZUMI
FUJITA, MASATAKA
SHINKAI, SACHIHIKO
SAKURAI, TAKASHI
NAKAYOSHI, TAKEMI
description A new cephamycin antibiotic, cefminox (MT-141, CMNX), was intravenously infused into Beagle dogs at a dose of 40 mg/kg in order to study it's distribution to various tissues. The following results were obtained. 1. The maximum serum concentration of CMNX observed at the end of the infusion period was 102.3 μg/ml, and then the concentration decreased. The biological half-life of CMNX in serum was 37.0 minutes. This half-life was similar to the results of previous studies with Beagle dogs and rabbits. 2. The maximum concentrations in tissues and body fluids were highest in B-bile followed by kidney, urinary bladder, serum, liver, vagina, uterus, pericardiac fluid, trachea, ovary, lung, gallbladder, parotid gland, heart, tonsil, thymus, spleen, pancreas, aqueous humor and cerebrospinal fluid, in that order and not detected in brain. The maximum concentrations in gallbladder, B-bile, pericardiac fluid and cerebrospinal fluid were found at 1-2 hours after administration. In other tissues and body fluids, they were obtained at the end of the infusion period. 3. The area under the tissue concentration curve (AUC) was highest in the urinary bladder followed by the kidney, vagina, liver, uterus, gallbladder, trachea, ovary and lung, in that order. These results suggest that CMNX is useful for various infectious diseases in these tissues. 4. The pharmacokinetic parameter (K11K21) derived from serum and tissue concentrations using the deconvolution method well correlated to maximum tissue concentrations.
doi_str_mv 10.11553/antibiotics1968b.38.1769
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_76493489</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76493489</sourcerecordid><originalsourceid>FETCH-LOGICAL-j189t-b675a7a624fe3696a8c5e2b8ba1c0c47b281b81bff05326cee05cfc3486125433</originalsourceid><addsrcrecordid>eNpdkE1Lw0AYhBdRaqn9CUK8eEvMfm-ObU1rsDZgUvC27K4bTUk_zCYH_71bWnoQXuY9zMPADAAPMI4gpBQ_qV1X63rf1cbBhAkdYRFBzpIrMERQsJASzq_BMMZMhIgLeAvGztU6xpAL5CMGYIATTAiCQxCVWVGs0-A5K8r3bLous3wV5PNgls7fslX-EWSrYJpOFkuP5IviDtxUqnF2fP4jsJ6n5ewlXOaLbDZZhhsoki7UjFPFFUOkspglTAlDLdJCK2hiQ7hGAmp_VRVTjJixNqamMpgIBhElGI_A4yn30O5_eus6ua2dsU2jdnbfO8kZ8Q1E4sH7M9jrrf2Uh7beqvZXngt6__Xkb1ynvuzFV62fr7Hy_5YSC8mPchz0Qplv1Uq7w383JmzV</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76493489</pqid></control><display><type>article</type><title>TISSUE DISTRIBUTION OF CEFMINOX IN BEAGLE DOGS</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>CHIBA, FUMIKO ; KOMIYA, IZUMI ; FUJITA, MASATAKA ; SHINKAI, SACHIHIKO ; SAKURAI, TAKASHI ; NAKAYOSHI, TAKEMI</creator><creatorcontrib>CHIBA, FUMIKO ; KOMIYA, IZUMI ; FUJITA, MASATAKA ; SHINKAI, SACHIHIKO ; SAKURAI, TAKASHI ; NAKAYOSHI, TAKEMI</creatorcontrib><description>A new cephamycin antibiotic, cefminox (MT-141, CMNX), was intravenously infused into Beagle dogs at a dose of 40 mg/kg in order to study it's distribution to various tissues. The following results were obtained. 1. The maximum serum concentration of CMNX observed at the end of the infusion period was 102.3 μg/ml, and then the concentration decreased. The biological half-life of CMNX in serum was 37.0 minutes. This half-life was similar to the results of previous studies with Beagle dogs and rabbits. 2. The maximum concentrations in tissues and body fluids were highest in B-bile followed by kidney, urinary bladder, serum, liver, vagina, uterus, pericardiac fluid, trachea, ovary, lung, gallbladder, parotid gland, heart, tonsil, thymus, spleen, pancreas, aqueous humor and cerebrospinal fluid, in that order and not detected in brain. The maximum concentrations in gallbladder, B-bile, pericardiac fluid and cerebrospinal fluid were found at 1-2 hours after administration. In other tissues and body fluids, they were obtained at the end of the infusion period. 3. The area under the tissue concentration curve (AUC) was highest in the urinary bladder followed by the kidney, vagina, liver, uterus, gallbladder, trachea, ovary and lung, in that order. These results suggest that CMNX is useful for various infectious diseases in these tissues. 4. The pharmacokinetic parameter (K11K21) derived from serum and tissue concentrations using the deconvolution method well correlated to maximum tissue concentrations.</description><identifier>ISSN: 0368-2781</identifier><identifier>EISSN: 2186-5477</identifier><identifier>DOI: 10.11553/antibiotics1968b.38.1769</identifier><identifier>PMID: 3934421</identifier><language>jpn</language><publisher>Japan: Japan Antibiotics Research Association</publisher><subject>Animals ; Cephamycins - administration &amp; dosage ; Cephamycins - blood ; Cephamycins - metabolism ; Dogs ; Female ; Half-Life ; Humans ; Infusions, Parenteral ; Kinetics ; Models, Biological ; Tissue Distribution</subject><ispartof>The Japanese Journal of Antibiotics, 1985/07/25, Vol.38(7), pp.1769-1775</ispartof><rights>Japan Antibiotics Research Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3934421$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHIBA, FUMIKO</creatorcontrib><creatorcontrib>KOMIYA, IZUMI</creatorcontrib><creatorcontrib>FUJITA, MASATAKA</creatorcontrib><creatorcontrib>SHINKAI, SACHIHIKO</creatorcontrib><creatorcontrib>SAKURAI, TAKASHI</creatorcontrib><creatorcontrib>NAKAYOSHI, TAKEMI</creatorcontrib><title>TISSUE DISTRIBUTION OF CEFMINOX IN BEAGLE DOGS</title><title>Japanese journal of antibiotics</title><addtitle>Jpn. J. Antibiotics</addtitle><description>A new cephamycin antibiotic, cefminox (MT-141, CMNX), was intravenously infused into Beagle dogs at a dose of 40 mg/kg in order to study it's distribution to various tissues. The following results were obtained. 1. The maximum serum concentration of CMNX observed at the end of the infusion period was 102.3 μg/ml, and then the concentration decreased. The biological half-life of CMNX in serum was 37.0 minutes. This half-life was similar to the results of previous studies with Beagle dogs and rabbits. 2. The maximum concentrations in tissues and body fluids were highest in B-bile followed by kidney, urinary bladder, serum, liver, vagina, uterus, pericardiac fluid, trachea, ovary, lung, gallbladder, parotid gland, heart, tonsil, thymus, spleen, pancreas, aqueous humor and cerebrospinal fluid, in that order and not detected in brain. The maximum concentrations in gallbladder, B-bile, pericardiac fluid and cerebrospinal fluid were found at 1-2 hours after administration. In other tissues and body fluids, they were obtained at the end of the infusion period. 3. The area under the tissue concentration curve (AUC) was highest in the urinary bladder followed by the kidney, vagina, liver, uterus, gallbladder, trachea, ovary and lung, in that order. These results suggest that CMNX is useful for various infectious diseases in these tissues. 4. The pharmacokinetic parameter (K11K21) derived from serum and tissue concentrations using the deconvolution method well correlated to maximum tissue concentrations.</description><subject>Animals</subject><subject>Cephamycins - administration &amp; dosage</subject><subject>Cephamycins - blood</subject><subject>Cephamycins - metabolism</subject><subject>Dogs</subject><subject>Female</subject><subject>Half-Life</subject><subject>Humans</subject><subject>Infusions, Parenteral</subject><subject>Kinetics</subject><subject>Models, Biological</subject><subject>Tissue Distribution</subject><issn>0368-2781</issn><issn>2186-5477</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE1Lw0AYhBdRaqn9CUK8eEvMfm-ObU1rsDZgUvC27K4bTUk_zCYH_71bWnoQXuY9zMPADAAPMI4gpBQ_qV1X63rf1cbBhAkdYRFBzpIrMERQsJASzq_BMMZMhIgLeAvGztU6xpAL5CMGYIATTAiCQxCVWVGs0-A5K8r3bLous3wV5PNgls7fslX-EWSrYJpOFkuP5IviDtxUqnF2fP4jsJ6n5ewlXOaLbDZZhhsoki7UjFPFFUOkspglTAlDLdJCK2hiQ7hGAmp_VRVTjJixNqamMpgIBhElGI_A4yn30O5_eus6ua2dsU2jdnbfO8kZ8Q1E4sH7M9jrrf2Uh7beqvZXngt6__Xkb1ynvuzFV62fr7Hy_5YSC8mPchz0Qplv1Uq7w383JmzV</recordid><startdate>198507</startdate><enddate>198507</enddate><creator>CHIBA, FUMIKO</creator><creator>KOMIYA, IZUMI</creator><creator>FUJITA, MASATAKA</creator><creator>SHINKAI, SACHIHIKO</creator><creator>SAKURAI, TAKASHI</creator><creator>NAKAYOSHI, TAKEMI</creator><general>Japan Antibiotics Research Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198507</creationdate><title>TISSUE DISTRIBUTION OF CEFMINOX IN BEAGLE DOGS</title><author>CHIBA, FUMIKO ; KOMIYA, IZUMI ; FUJITA, MASATAKA ; SHINKAI, SACHIHIKO ; SAKURAI, TAKASHI ; NAKAYOSHI, TAKEMI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j189t-b675a7a624fe3696a8c5e2b8ba1c0c47b281b81bff05326cee05cfc3486125433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Cephamycins - administration &amp; dosage</topic><topic>Cephamycins - blood</topic><topic>Cephamycins - metabolism</topic><topic>Dogs</topic><topic>Female</topic><topic>Half-Life</topic><topic>Humans</topic><topic>Infusions, Parenteral</topic><topic>Kinetics</topic><topic>Models, Biological</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHIBA, FUMIKO</creatorcontrib><creatorcontrib>KOMIYA, IZUMI</creatorcontrib><creatorcontrib>FUJITA, MASATAKA</creatorcontrib><creatorcontrib>SHINKAI, SACHIHIKO</creatorcontrib><creatorcontrib>SAKURAI, TAKASHI</creatorcontrib><creatorcontrib>NAKAYOSHI, TAKEMI</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHIBA, FUMIKO</au><au>KOMIYA, IZUMI</au><au>FUJITA, MASATAKA</au><au>SHINKAI, SACHIHIKO</au><au>SAKURAI, TAKASHI</au><au>NAKAYOSHI, TAKEMI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TISSUE DISTRIBUTION OF CEFMINOX IN BEAGLE DOGS</atitle><jtitle>Japanese journal of antibiotics</jtitle><addtitle>Jpn. J. Antibiotics</addtitle><date>1985-07</date><risdate>1985</risdate><volume>38</volume><issue>7</issue><spage>1769</spage><epage>1775</epage><pages>1769-1775</pages><issn>0368-2781</issn><eissn>2186-5477</eissn><abstract>A new cephamycin antibiotic, cefminox (MT-141, CMNX), was intravenously infused into Beagle dogs at a dose of 40 mg/kg in order to study it's distribution to various tissues. The following results were obtained. 1. The maximum serum concentration of CMNX observed at the end of the infusion period was 102.3 μg/ml, and then the concentration decreased. The biological half-life of CMNX in serum was 37.0 minutes. This half-life was similar to the results of previous studies with Beagle dogs and rabbits. 2. The maximum concentrations in tissues and body fluids were highest in B-bile followed by kidney, urinary bladder, serum, liver, vagina, uterus, pericardiac fluid, trachea, ovary, lung, gallbladder, parotid gland, heart, tonsil, thymus, spleen, pancreas, aqueous humor and cerebrospinal fluid, in that order and not detected in brain. The maximum concentrations in gallbladder, B-bile, pericardiac fluid and cerebrospinal fluid were found at 1-2 hours after administration. In other tissues and body fluids, they were obtained at the end of the infusion period. 3. The area under the tissue concentration curve (AUC) was highest in the urinary bladder followed by the kidney, vagina, liver, uterus, gallbladder, trachea, ovary and lung, in that order. These results suggest that CMNX is useful for various infectious diseases in these tissues. 4. The pharmacokinetic parameter (K11K21) derived from serum and tissue concentrations using the deconvolution method well correlated to maximum tissue concentrations.</abstract><cop>Japan</cop><pub>Japan Antibiotics Research Association</pub><pmid>3934421</pmid><doi>10.11553/antibiotics1968b.38.1769</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0368-2781
ispartof The Japanese Journal of Antibiotics, 1985/07/25, Vol.38(7), pp.1769-1775
issn 0368-2781
2186-5477
language jpn
recordid cdi_proquest_miscellaneous_76493489
source MEDLINE; EZB-FREE-00999 freely available EZB journals
subjects Animals
Cephamycins - administration & dosage
Cephamycins - blood
Cephamycins - metabolism
Dogs
Female
Half-Life
Humans
Infusions, Parenteral
Kinetics
Models, Biological
Tissue Distribution
title TISSUE DISTRIBUTION OF CEFMINOX IN BEAGLE DOGS
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T13%3A29%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=TISSUE%20DISTRIBUTION%20OF%20CEFMINOX%20IN%20BEAGLE%20DOGS&rft.jtitle=Japanese%20journal%20of%20antibiotics&rft.au=CHIBA,%20FUMIKO&rft.date=1985-07&rft.volume=38&rft.issue=7&rft.spage=1769&rft.epage=1775&rft.pages=1769-1775&rft.issn=0368-2781&rft.eissn=2186-5477&rft_id=info:doi/10.11553/antibiotics1968b.38.1769&rft_dat=%3Cproquest_pubme%3E76493489%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76493489&rft_id=info:pmid/3934421&rfr_iscdi=true