Post-transfusion hemochromatosis. Results of a study carried out in Blood Transfusion Centers. Analysis of 15 cases treated with subcutaneous perfusion of Desferal. Working group "Transfusion Techniques and Therapeutics"
Post-transfusional iron overload is a real problem for doctors in charge of transfusions, as shown by the survey we led in twenty French blood banks. Deferoxamine remains the most efficient chelator, but can be prescribed only in a parenteral way. It is now proved that continuous infusions, intraven...
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| Veröffentlicht in: | Transfusion clinique et biologique : journal de la Société française de transfusion sanguine 1994, Vol.1 (1), p.55-64 |
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| container_title | Transfusion clinique et biologique : journal de la Société française de transfusion sanguine |
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| creator | Jaulmes, D Quarre, M C Audat, F Gaonach, M J |
| description | Post-transfusional iron overload is a real problem for doctors in charge of transfusions, as shown by the survey we led in twenty French blood banks. Deferoxamine remains the most efficient chelator, but can be prescribed only in a parenteral way. It is now proved that continuous infusions, intravenous or subcutaneous, are preferable to intermittent injections as far as iron excretion is concerned. In our study, we selected 15 polytransfused patients for dysmyelopoiesis. 13 cases were analysed by measuring the serum ferritin level. A clear decrease was noted, as well as a relative normalization of serum alanine amino transferases. However, if this treatment is effective and well tolerated, the problem is that it obviously requires the patient's compliance. It seems important to us to optimize prevention and treatment of post-transfusional iron overload through a consensus. |
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A clear decrease was noted, as well as a relative normalization of serum alanine amino transferases. However, if this treatment is effective and well tolerated, the problem is that it obviously requires the patient's compliance. 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However, if this treatment is effective and well tolerated, the problem is that it obviously requires the patient's compliance. It seems important to us to optimize prevention and treatment of post-transfusional iron overload through a consensus.</description><subject>Deferoxamine - administration & dosage</subject><subject>France</subject><subject>Hemochromatosis - drug therapy</subject><subject>Hemochromatosis - etiology</subject><subject>Humans</subject><subject>Injections, Subcutaneous</subject><subject>Perfusion</subject><subject>Retrospective Studies</subject><subject>Transfusion Reaction</subject><issn>1246-7820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkb9u2zAQhzWkcNOkj1CAyNBNBimRojQ6TtIWMNCiMJDROEkni4lEqjwShd-1D1Ma8ZDplt_33b-r7FoUssp1XfCP2SeiF86FFo1eZata1FWt1HX275ejkAcPloZIxlk24uy60bsZgiNDa_YbKU6BmBsYMAqxP7EOvDfYMxcDM5bdT871bP9OskUb0Cd4Y2E6Jc2ZFiqBhMSCRwgJ_2vCyCi2XQxg0UViC_qLIeUfkAb0MK3Zs_Ovxh7Z0bu4sLv3nfbYjdb8iUkLNg0xJmLBGExHd7fZhwEmws-XepPtnx732-_57ue3H9vNLl9UqXIQgG3XFOkyqm2lKqUGxAoarVUvZMGHQvBaNlBjoWQ5cF3LQWjkUCs5VLK8yb6-aRfvzoOEw2yow2l6W-qgK9kUnJcp-OUSjO2M_WHxZgZ_Oly-Uf4HksGKhA</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>Jaulmes, D</creator><creator>Quarre, M C</creator><creator>Audat, F</creator><creator>Gaonach, M J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>1994</creationdate><title>Post-transfusion hemochromatosis. Results of a study carried out in Blood Transfusion Centers. Analysis of 15 cases treated with subcutaneous perfusion of Desferal. 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Results of a study carried out in Blood Transfusion Centers. Analysis of 15 cases treated with subcutaneous perfusion of Desferal. Working group "Transfusion Techniques and Therapeutics"</atitle><jtitle>Transfusion clinique et biologique : journal de la Société française de transfusion sanguine</jtitle><addtitle>Transfus Clin Biol</addtitle><date>1994</date><risdate>1994</risdate><volume>1</volume><issue>1</issue><spage>55</spage><epage>64</epage><pages>55-64</pages><issn>1246-7820</issn><abstract>Post-transfusional iron overload is a real problem for doctors in charge of transfusions, as shown by the survey we led in twenty French blood banks. Deferoxamine remains the most efficient chelator, but can be prescribed only in a parenteral way. It is now proved that continuous infusions, intravenous or subcutaneous, are preferable to intermittent injections as far as iron excretion is concerned. In our study, we selected 15 polytransfused patients for dysmyelopoiesis. 13 cases were analysed by measuring the serum ferritin level. A clear decrease was noted, as well as a relative normalization of serum alanine amino transferases. However, if this treatment is effective and well tolerated, the problem is that it obviously requires the patient's compliance. It seems important to us to optimize prevention and treatment of post-transfusional iron overload through a consensus.</abstract><cop>France</cop><pmid>8186855</pmid><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 1246-7820 |
| ispartof | Transfusion clinique et biologique : journal de la Société française de transfusion sanguine, 1994, Vol.1 (1), p.55-64 |
| issn | 1246-7820 |
| language | fre |
| recordid | cdi_proquest_miscellaneous_76492003 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Deferoxamine - administration & dosage France Hemochromatosis - drug therapy Hemochromatosis - etiology Humans Injections, Subcutaneous Perfusion Retrospective Studies Transfusion Reaction |
| title | Post-transfusion hemochromatosis. Results of a study carried out in Blood Transfusion Centers. Analysis of 15 cases treated with subcutaneous perfusion of Desferal. Working group "Transfusion Techniques and Therapeutics" |
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