Design of Inhibitors of Glycogen Phosphorylase: A Study of .alpha.- and .beta.-C-Glucosides and 1-Thio-.beta.-D-glucose Compounds

alpha-D-Glucose is a weak inhibitor of glycogen phosphorylase b (Ki = 1.7 mM) and acts as a physiological regulator of hepatic glycogen metabolism. Glucose binds to phosphorylase at the catalytic site and results in a conformational change that stabilizes the inactive T state of the enzyme, promotin...

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Veröffentlicht in:	Biochemistry (Easton) 1994-05, Vol.33 (19), p.5745-5758
Hauptverfasser:	Watson, Kimberly A, Mitchell, Edward P, Johnson, Louise N, Bichard, Claire J. F, Orchard, Michael G, Fleet, George W. J, Oikonomakos, Nikos G, Leonidas, D. D, Son, Jong Chan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbohydrate Conformation Crystallography, X-Ray Drug Design Glucose - analogs & derivatives Glucose - chemistry Glucose - pharmacology Hydrogen Bonding Kinetics Models, Molecular Muscles - enzymology Phosphorylases - antagonists & inhibitors Protein Conformation Rabbits Sugar Acids - chemistry Sugar Acids - pharmacology
Online-Zugang:	Volltext
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