High Effectiveness of Aerosolized Chick Embryo Fibroblast Measles Vaccine in Seven-Month-Old and Older Infants
Neither the presence of hypertonic sugar nor the absence of 1% human albumin in the aerosolized chick embryo fibroblast (CEF) measles vaccine was previously found to be responsible for its inadequacy in infants with titers of maternal plaque-neutralizing (PN) antibody at which human diploid cell mea...
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| Veröffentlicht in: | The Journal of infectious diseases 1985-12, Vol.152 (6), p.1231-1237 |
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| container_title | The Journal of infectious diseases |
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| creator | Sabin, Albert B. Albrecht, Paul Takeda, Augusta K. Ribeiro, Expedito M. Veronesi, Ricardo |
| description | Neither the presence of hypertonic sugar nor the absence of 1% human albumin in the aerosolized chick embryo fibroblast (CEF) measles vaccine was previously found to be responsible for its inadequacy in infants with titers of maternal plaque-neutralizing (PN) antibody at which human diploid cell measles vaccine was immunogenic. Eight weeks after administration of CEF measles vaccine containing 1% human albumin, antibody had developed in all 10 infants 7–10 months old and all 11 children 12–35 months old but in only 26% of 23 infants 3–5 months old and 67% of 9 infants 6 momhs of age. Failure of antibody development was associated with prevaccination PN antibody titers of 〉/1:50 (with one exception at a titer of 1:25). The PN antibody response to CEF vaccine (diluted 1:10, ∼105 pfu/ml) in infants under seven months of age (geometric mean titer [GMT], 1:421) was significantly lower (P |
| doi_str_mv | 10.1093/infdis/152.6.1231 |
| format | Article |
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Eight weeks after administration of CEF measles vaccine containing 1% human albumin, antibody had developed in all 10 infants 7–10 months old and all 11 children 12–35 months old but in only 26% of 23 infants 3–5 months old and 67% of 9 infants 6 momhs of age. Failure of antibody development was associated with prevaccination PN antibody titers of 〉/1:50 (with one exception at a titer of 1:25). The PN antibody response to CEF vaccine (diluted 1:10, ∼105 pfu/ml) in infants under seven months of age (geometric mean titer [GMT], 1:421) was significantly lower (P <.005) than in older infants (GMT, 1:1,564). At a 1:1,000 dilution of vaccine, only 50% of 10 infants 13–25 months old, 20% of 15 infants 7–10 months old, and none of 8 infants 6 months old developed antibody.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/152.6.1231</identifier><identifier>PMID: 3905984</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Administration, Intranasal ; Aerosols ; Age Factors ; Albumins ; Animals ; Antibodies ; Antibodies, Viral - analysis ; Antibodies, Viral - biosynthesis ; Biological and medical sciences ; Chick Embryo ; Child, Preschool ; Children ; Clinical Trials as Topic ; Cough - etiology ; Fever - etiology ; Fibroblasts ; Fundamental and applied biological sciences. Psychology ; Hemagglutination Inhibition Tests ; Humans ; Immune response ; Immunity, Maternally-Acquired ; Infant ; Infants ; Inhalation ; Measles ; Measles Vaccine - administration & dosage ; Measles Vaccine - adverse effects ; Measles Vaccine - immunology ; Measles vaccines ; measles virus ; Microbiology ; Neutralization Tests ; Original Articles ; Sugars ; Vaccination ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; Viral Plaque Assay ; Virology</subject><ispartof>The Journal of infectious diseases, 1985-12, Vol.152 (6), p.1231-1237</ispartof><rights>Copyright 1985 The University of Chicago</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c331t-56aadcfa3e8b7b219d3dff2ededfa68108f9c518c7e1a001e85f7c6c55858d563</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30104782$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30104782$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,778,782,801,27911,27912,58004,58237</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8569863$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3905984$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sabin, Albert B.</creatorcontrib><creatorcontrib>Albrecht, Paul</creatorcontrib><creatorcontrib>Takeda, Augusta K.</creatorcontrib><creatorcontrib>Ribeiro, Expedito M.</creatorcontrib><creatorcontrib>Veronesi, Ricardo</creatorcontrib><title>High Effectiveness of Aerosolized Chick Embryo Fibroblast Measles Vaccine in Seven-Month-Old and Older Infants</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Neither the presence of hypertonic sugar nor the absence of 1% human albumin in the aerosolized chick embryo fibroblast (CEF) measles vaccine was previously found to be responsible for its inadequacy in infants with titers of maternal plaque-neutralizing (PN) antibody at which human diploid cell measles vaccine was immunogenic. Eight weeks after administration of CEF measles vaccine containing 1% human albumin, antibody had developed in all 10 infants 7–10 months old and all 11 children 12–35 months old but in only 26% of 23 infants 3–5 months old and 67% of 9 infants 6 momhs of age. Failure of antibody development was associated with prevaccination PN antibody titers of 〉/1:50 (with one exception at a titer of 1:25). The PN antibody response to CEF vaccine (diluted 1:10, ∼105 pfu/ml) in infants under seven months of age (geometric mean titer [GMT], 1:421) was significantly lower (P <.005) than in older infants (GMT, 1:1,564). At a 1:1,000 dilution of vaccine, only 50% of 10 infants 13–25 months old, 20% of 15 infants 7–10 months old, and none of 8 infants 6 months old developed antibody.</description><subject>Administration, Intranasal</subject><subject>Aerosols</subject><subject>Age Factors</subject><subject>Albumins</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Viral - analysis</subject><subject>Antibodies, Viral - biosynthesis</subject><subject>Biological and medical sciences</subject><subject>Chick Embryo</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Clinical Trials as Topic</subject><subject>Cough - etiology</subject><subject>Fever - etiology</subject><subject>Fibroblasts</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hemagglutination Inhibition Tests</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immunity, Maternally-Acquired</subject><subject>Infant</subject><subject>Infants</subject><subject>Inhalation</subject><subject>Measles</subject><subject>Measles Vaccine - administration & dosage</subject><subject>Measles Vaccine - adverse effects</subject><subject>Measles Vaccine - immunology</subject><subject>Measles vaccines</subject><subject>measles virus</subject><subject>Microbiology</subject><subject>Neutralization Tests</subject><subject>Original Articles</subject><subject>Sugars</subject><subject>Vaccination</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><subject>Viral Plaque Assay</subject><subject>Virology</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9PGzEUxK2qiKa0H6CHSj5UvW2w1-t_RxQlDVKAA7RCXCyv_dwYNl6wN1Xpp-9GSeHY0zvMzE9PMwh9omRKiWanMQUfyynl9VRMac3oGzShnMlKCMreogkhdV1RpfU79L6Ue0JIw4Q8RsdME65VM0FpGX-u8TwEcEP8BQlKwX3AZ5D70nfxD3g8W0f3gOebNj_3eBHb3LedLQO-AFs6KPiHdS4mwDHhaxgR1UWfhnV11Xlsk8fjhYzPU7BpKB_QUbBdgY-He4K-L-Y3s2W1uvp2PjtbVY4xOlRcWOtdsAxUK9uaas98CDV48MEKRYkK2nGqnARqCaGgeJBOOM4VV54LdoK-7rmPuX_aQhnMJhYHXWcT9NtipGiUFpz-10ibhjS1rkcj3Rvd2EzJEMxjjhubnw0lZjeG2Y9hxjGMMLsxxsznA3zbbsC_JA7tj_qXg26Ls13INrmR8M-muNBKsFfMfRn6_EohlDRS7V6r9nosA_x-0W1-MEIyyc3y9s5cL1ZEX95Is2J_AcAkrRw</recordid><startdate>19851201</startdate><enddate>19851201</enddate><creator>Sabin, Albert B.</creator><creator>Albrecht, Paul</creator><creator>Takeda, Augusta K.</creator><creator>Ribeiro, Expedito M.</creator><creator>Veronesi, Ricardo</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19851201</creationdate><title>High Effectiveness of Aerosolized Chick Embryo Fibroblast Measles Vaccine in Seven-Month-Old and Older Infants</title><author>Sabin, Albert B. ; Albrecht, Paul ; Takeda, Augusta K. ; Ribeiro, Expedito M. ; Veronesi, Ricardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c331t-56aadcfa3e8b7b219d3dff2ededfa68108f9c518c7e1a001e85f7c6c55858d563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Administration, Intranasal</topic><topic>Aerosols</topic><topic>Age Factors</topic><topic>Albumins</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Viral - analysis</topic><topic>Antibodies, Viral - biosynthesis</topic><topic>Biological and medical sciences</topic><topic>Chick Embryo</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Clinical Trials as Topic</topic><topic>Cough - etiology</topic><topic>Fever - etiology</topic><topic>Fibroblasts</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hemagglutination Inhibition Tests</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immunity, Maternally-Acquired</topic><topic>Infant</topic><topic>Infants</topic><topic>Inhalation</topic><topic>Measles</topic><topic>Measles Vaccine - administration & dosage</topic><topic>Measles Vaccine - adverse effects</topic><topic>Measles Vaccine - immunology</topic><topic>Measles vaccines</topic><topic>measles virus</topic><topic>Microbiology</topic><topic>Neutralization Tests</topic><topic>Original Articles</topic><topic>Sugars</topic><topic>Vaccination</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><topic>Viral Plaque Assay</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sabin, Albert B.</creatorcontrib><creatorcontrib>Albrecht, Paul</creatorcontrib><creatorcontrib>Takeda, Augusta K.</creatorcontrib><creatorcontrib>Ribeiro, Expedito M.</creatorcontrib><creatorcontrib>Veronesi, Ricardo</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sabin, Albert B.</au><au>Albrecht, Paul</au><au>Takeda, Augusta K.</au><au>Ribeiro, Expedito M.</au><au>Veronesi, Ricardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High Effectiveness of Aerosolized Chick Embryo Fibroblast Measles Vaccine in Seven-Month-Old and Older Infants</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1985-12-01</date><risdate>1985</risdate><volume>152</volume><issue>6</issue><spage>1231</spage><epage>1237</epage><pages>1231-1237</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Neither the presence of hypertonic sugar nor the absence of 1% human albumin in the aerosolized chick embryo fibroblast (CEF) measles vaccine was previously found to be responsible for its inadequacy in infants with titers of maternal plaque-neutralizing (PN) antibody at which human diploid cell measles vaccine was immunogenic. Eight weeks after administration of CEF measles vaccine containing 1% human albumin, antibody had developed in all 10 infants 7–10 months old and all 11 children 12–35 months old but in only 26% of 23 infants 3–5 months old and 67% of 9 infants 6 momhs of age. Failure of antibody development was associated with prevaccination PN antibody titers of 〉/1:50 (with one exception at a titer of 1:25). The PN antibody response to CEF vaccine (diluted 1:10, ∼105 pfu/ml) in infants under seven months of age (geometric mean titer [GMT], 1:421) was significantly lower (P <.005) than in older infants (GMT, 1:1,564). At a 1:1,000 dilution of vaccine, only 50% of 10 infants 13–25 months old, 20% of 15 infants 7–10 months old, and none of 8 infants 6 months old developed antibody.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>3905984</pmid><doi>10.1093/infdis/152.6.1231</doi><tpages>7</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 1985-12, Vol.152 (6), p.1231-1237 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | MEDLINE; Jstor Complete Legacy |
| subjects | Administration, Intranasal Aerosols Age Factors Albumins Animals Antibodies Antibodies, Viral - analysis Antibodies, Viral - biosynthesis Biological and medical sciences Chick Embryo Child, Preschool Children Clinical Trials as Topic Cough - etiology Fever - etiology Fibroblasts Fundamental and applied biological sciences. Psychology Hemagglutination Inhibition Tests Humans Immune response Immunity, Maternally-Acquired Infant Infants Inhalation Measles Measles Vaccine - administration & dosage Measles Vaccine - adverse effects Measles Vaccine - immunology Measles vaccines measles virus Microbiology Neutralization Tests Original Articles Sugars Vaccination Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Viral Plaque Assay Virology |
| title | High Effectiveness of Aerosolized Chick Embryo Fibroblast Measles Vaccine in Seven-Month-Old and Older Infants |
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