FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain regionalisation and epithelial-mesenchymal interactions
We have isolated cDNA and genomic clones for the murine FGF-7 gene and examined its expression throughout development. Transcripts were transiently detected in the developing myocardium, differentially regulated between the atrium and ventricle. The gene was also expressed in the myotomes of the som...
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| Veröffentlicht in: | Mechanisms of development 1994, Vol.45 (1), p.15-30 |
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| creator | Mason, Ivor J. Fuller-Pace, Frances Smith, Rosalind Dickson, Clive |
| description | We have isolated cDNA and genomic clones for the murine FGF-7 gene and examined its expression throughout development. Transcripts were transiently detected in the developing myocardium, differentially regulated between the atrium and ventricle. The gene was also expressed in the myotomes of the somites, coincident with FGF-4 and FGF-5 transcripts, and was detected transiently in cleaved muscles. Regional expression was detected in the ventricular zone of the developing forebrain at 14.5 d.p.c. Later in development, FGF-7 RNA was detected in mesenchymal tissues suggesting a role in epithelial-mesenchymal interactions and in the dermis consistent with its proposed role as a keratinocyte mitogen. Our results suggest that FGF-7 is likely to have diverse roles during development. |
| doi_str_mv | 10.1016/0925-4773(94)90050-7 |
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Transcripts were transiently detected in the developing myocardium, differentially regulated between the atrium and ventricle. The gene was also expressed in the myotomes of the somites, coincident with FGF-4 and FGF-5 transcripts, and was detected transiently in cleaved muscles. Regional expression was detected in the ventricular zone of the developing forebrain at 14.5 d.p.c. Later in development, FGF-7 RNA was detected in mesenchymal tissues suggesting a role in epithelial-mesenchymal interactions and in the dermis consistent with its proposed role as a keratinocyte mitogen. Our results suggest that FGF-7 is likely to have diverse roles during development.</description><identifier>ISSN: 0925-4773</identifier><identifier>EISSN: 1872-6356</identifier><identifier>DOI: 10.1016/0925-4773(94)90050-7</identifier><identifier>PMID: 8186145</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Amino Acid Sequence ; Animals ; Base Sequence ; Biological and medical sciences ; Cell Communication - physiology ; Cloning, Molecular ; DNA - analysis ; DNA - genetics ; Embryology: invertebrates and vertebrates. Teratology ; Epithelial Cells ; Epithelial-mesenchymal interaction ; Epithelium - physiology ; Fibroblast growth factor ; Fibroblast Growth Factor 10 ; Fibroblast Growth Factor 7 ; Fibroblast Growth Factors ; Forebrain ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation - genetics ; Growth Substances - genetics ; Growth Substances - physiology ; Heart - embryology ; Keratinocytes - chemistry ; Keratinocytes - cytology ; KGF ; Mesoderm - cytology ; Mesoderm - physiology ; Mice ; Mice, Inbred Strains - embryology ; Molecular embryology ; Molecular Sequence Data ; Morphogenesis - physiology ; Muscles - embryology ; Muscles - physiology ; Myocardium ; Prosencephalon - embryology ; Prosencephalon - physiology ; RNA, Messenger - analysis ; RNA, Messenger - genetics ; Skeletal muscle ; Transcription, Genetic</subject><ispartof>Mechanisms of development, 1994, Vol.45 (1), p.15-30</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-cf339ea4f23f5e36ea2d2e3468806e37d8f6b78b3d369b93ff6ead01579292783</citedby><cites>FETCH-LOGICAL-c367t-cf339ea4f23f5e36ea2d2e3468806e37d8f6b78b3d369b93ff6ead01579292783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0925477394900507$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4030618$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8186145$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mason, Ivor J.</creatorcontrib><creatorcontrib>Fuller-Pace, Frances</creatorcontrib><creatorcontrib>Smith, Rosalind</creatorcontrib><creatorcontrib>Dickson, Clive</creatorcontrib><title>FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain regionalisation and epithelial-mesenchymal interactions</title><title>Mechanisms of development</title><addtitle>Mech Dev</addtitle><description>We have isolated cDNA and genomic clones for the murine FGF-7 gene and examined its expression throughout development. Transcripts were transiently detected in the developing myocardium, differentially regulated between the atrium and ventricle. The gene was also expressed in the myotomes of the somites, coincident with FGF-4 and FGF-5 transcripts, and was detected transiently in cleaved muscles. Regional expression was detected in the ventricular zone of the developing forebrain at 14.5 d.p.c. Later in development, FGF-7 RNA was detected in mesenchymal tissues suggesting a role in epithelial-mesenchymal interactions and in the dermis consistent with its proposed role as a keratinocyte mitogen. Our results suggest that FGF-7 is likely to have diverse roles during development.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cell Communication - physiology</subject><subject>Cloning, Molecular</subject><subject>DNA - analysis</subject><subject>DNA - genetics</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Epithelial Cells</subject><subject>Epithelial-mesenchymal interaction</subject><subject>Epithelium - physiology</subject><subject>Fibroblast growth factor</subject><subject>Fibroblast Growth Factor 10</subject><subject>Fibroblast Growth Factor 7</subject><subject>Fibroblast Growth Factors</subject><subject>Forebrain</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation - genetics</subject><subject>Growth Substances - genetics</subject><subject>Growth Substances - physiology</subject><subject>Heart - embryology</subject><subject>Keratinocytes - chemistry</subject><subject>Keratinocytes - cytology</subject><subject>KGF</subject><subject>Mesoderm - cytology</subject><subject>Mesoderm - physiology</subject><subject>Mice</subject><subject>Mice, Inbred Strains - embryology</subject><subject>Molecular embryology</subject><subject>Molecular Sequence Data</subject><subject>Morphogenesis - physiology</subject><subject>Muscles - embryology</subject><subject>Muscles - physiology</subject><subject>Myocardium</subject><subject>Prosencephalon - embryology</subject><subject>Prosencephalon - physiology</subject><subject>RNA, Messenger - analysis</subject><subject>RNA, Messenger - genetics</subject><subject>Skeletal muscle</subject><subject>Transcription, Genetic</subject><issn>0925-4773</issn><issn>1872-6356</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAQhiMEKkvhDUDyAaFWImDHiZ1cKqGKLUiVuMDZcuxx1pDYiycp7AvxnDjsao-cLM188_uff4riJaPvGGXiPe2qpqyl5Fddfd1R2tBSPio2rJVVKXgjHhebM_K0eIb4nVLKmGAXxUXLWsHqZlP82d5tS0mufkDSsw_RHGYgQ4q_5h1x2swxXRP4vU-A6GMgdkk-DGSKCwKx8ABj3E8QZoLLMADOSFIcAYkPZDrEAQKgx7fExQR90rmaYMg6evSYv8uCOlgCez_vYPR6LCdACGZ3mPSYNeZsyqwYPi-eOD0ivDi9l8W37cevt5_K-y93n28_3JeGCzmXxnHega5dxV0DXICubAW8Fm1LBXBpWyd62fbcctH1HXcuI5ayRnZVV8mWXxZvjrr7FH8ueSE1eTQwjjpA3llJUbedYCyD9RE0KSImcGqf_KTTQTGq1vOoNXu1Zq-6Wv07j5J57NVJf-knsOeh0z1y__Wpr9Ho0SUdjMczVlNOBVtt3hwxyFk8eEgKjc_BgfUJzKxs9P_38Rf3C7Bl</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>Mason, Ivor J.</creator><creator>Fuller-Pace, Frances</creator><creator>Smith, Rosalind</creator><creator>Dickson, Clive</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1994</creationdate><title>FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain regionalisation and epithelial-mesenchymal interactions</title><author>Mason, Ivor J. ; Fuller-Pace, Frances ; Smith, Rosalind ; Dickson, Clive</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-cf339ea4f23f5e36ea2d2e3468806e37d8f6b78b3d369b93ff6ead01579292783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Cell Communication - physiology</topic><topic>Cloning, Molecular</topic><topic>DNA - analysis</topic><topic>DNA - genetics</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Epithelial Cells</topic><topic>Epithelial-mesenchymal interaction</topic><topic>Epithelium - physiology</topic><topic>Fibroblast growth factor</topic><topic>Fibroblast Growth Factor 10</topic><topic>Fibroblast Growth Factor 7</topic><topic>Fibroblast Growth Factors</topic><topic>Forebrain</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation - genetics</topic><topic>Growth Substances - genetics</topic><topic>Growth Substances - physiology</topic><topic>Heart - embryology</topic><topic>Keratinocytes - chemistry</topic><topic>Keratinocytes - cytology</topic><topic>KGF</topic><topic>Mesoderm - cytology</topic><topic>Mesoderm - physiology</topic><topic>Mice</topic><topic>Mice, Inbred Strains - embryology</topic><topic>Molecular embryology</topic><topic>Molecular Sequence Data</topic><topic>Morphogenesis - physiology</topic><topic>Muscles - embryology</topic><topic>Muscles - physiology</topic><topic>Myocardium</topic><topic>Prosencephalon - embryology</topic><topic>Prosencephalon - physiology</topic><topic>RNA, Messenger - analysis</topic><topic>RNA, Messenger - genetics</topic><topic>Skeletal muscle</topic><topic>Transcription, Genetic</topic><toplevel>online_resources</toplevel><creatorcontrib>Mason, Ivor J.</creatorcontrib><creatorcontrib>Fuller-Pace, Frances</creatorcontrib><creatorcontrib>Smith, Rosalind</creatorcontrib><creatorcontrib>Dickson, Clive</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Mechanisms of development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mason, Ivor J.</au><au>Fuller-Pace, Frances</au><au>Smith, Rosalind</au><au>Dickson, Clive</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain regionalisation and epithelial-mesenchymal interactions</atitle><jtitle>Mechanisms of development</jtitle><addtitle>Mech Dev</addtitle><date>1994</date><risdate>1994</risdate><volume>45</volume><issue>1</issue><spage>15</spage><epage>30</epage><pages>15-30</pages><issn>0925-4773</issn><eissn>1872-6356</eissn><abstract>We have isolated cDNA and genomic clones for the murine FGF-7 gene and examined its expression throughout development. Transcripts were transiently detected in the developing myocardium, differentially regulated between the atrium and ventricle. The gene was also expressed in the myotomes of the somites, coincident with FGF-4 and FGF-5 transcripts, and was detected transiently in cleaved muscles. Regional expression was detected in the ventricular zone of the developing forebrain at 14.5 d.p.c. Later in development, FGF-7 RNA was detected in mesenchymal tissues suggesting a role in epithelial-mesenchymal interactions and in the dermis consistent with its proposed role as a keratinocyte mitogen. Our results suggest that FGF-7 is likely to have diverse roles during development.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>8186145</pmid><doi>10.1016/0925-4773(94)90050-7</doi><tpages>16</tpages></addata></record> |
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| subjects | Amino Acid Sequence Animals Base Sequence Biological and medical sciences Cell Communication - physiology Cloning, Molecular DNA - analysis DNA - genetics Embryology: invertebrates and vertebrates. Teratology Epithelial Cells Epithelial-mesenchymal interaction Epithelium - physiology Fibroblast growth factor Fibroblast Growth Factor 10 Fibroblast Growth Factor 7 Fibroblast Growth Factors Forebrain Fundamental and applied biological sciences. Psychology Gene Expression Regulation - genetics Growth Substances - genetics Growth Substances - physiology Heart - embryology Keratinocytes - chemistry Keratinocytes - cytology KGF Mesoderm - cytology Mesoderm - physiology Mice Mice, Inbred Strains - embryology Molecular embryology Molecular Sequence Data Morphogenesis - physiology Muscles - embryology Muscles - physiology Myocardium Prosencephalon - embryology Prosencephalon - physiology RNA, Messenger - analysis RNA, Messenger - genetics Skeletal muscle Transcription, Genetic |
| title | FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain regionalisation and epithelial-mesenchymal interactions |
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