Tumor-Induced Osteomalacia -- Unveiling a New Hormone
Phosphate plays a critical part in the regulation of cell metabolism, and phosphate homeostasis is closely regulated in normal humans. Indeed, like serum calcium, serum phosphate is maintained within a narrow range of values, and people with abnormal concentrations may have a predisposition to life-...
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| Veröffentlicht in: | The New England journal of medicine 1994-06, Vol.330 (23), p.1679-1681 |
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| container_end_page | 1681 |
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| container_title | The New England journal of medicine |
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| creator | Econs, Michael J Drezner, Marc K |
| description | Phosphate plays a critical part in the regulation of cell metabolism, and phosphate homeostasis is closely regulated in normal humans. Indeed, like serum calcium, serum phosphate is maintained within a narrow range of values, and people with abnormal concentrations may have a predisposition to life-threatening conditions, such as hemolysis, myopathy, hypocalcemia, and nephrocalcinosis.
The principal organ that regulates phosphate homeostasis is the kidney. Regulation is accomplished partly through variation in glomerular filtration of phosphate but primarily through variation in renal tubular reabsorption of phosphate. These variations are detectable within 24 hours after a change in dietary phosphate intake and even . . . |
| doi_str_mv | 10.1056/NEJM199406093302310 |
| format | Article |
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The principal organ that regulates phosphate homeostasis is the kidney. Regulation is accomplished partly through variation in glomerular filtration of phosphate but primarily through variation in renal tubular reabsorption of phosphate. These variations are detectable within 24 hours after a change in dietary phosphate intake and even . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199406093302310</identifier><identifier>PMID: 8177274</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Animals ; Biological and medical sciences ; Calcification ; Chromosomes ; Dietary intake ; Diseases of the osteoarticular system ; Homeostasis ; Hormones ; Humans ; Hypophosphatemia - genetics ; Hypophosphatemia - metabolism ; Kidney - metabolism ; Kidneys ; Medical sciences ; Metabolism ; Neoplasms - complications ; Osteomalacia ; Osteomalacia - etiology ; Osteomalacia - metabolism ; Osteoporosis. Osteomalacia. Paget disease ; Pathogenesis ; Patients ; Phosphates - metabolism ; Rodents ; Tumors ; Vitamin D</subject><ispartof>The New England journal of medicine, 1994-06, Vol.330 (23), p.1679-1681</ispartof><rights>Copyright © 1994 Massachusetts Medical Society. All rights reserved.</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-c034404a56b0f8445c2ef72a4ded35779eb5f9178e1da7df79afb788b3dcdc863</citedby><cites>FETCH-LOGICAL-c525t-c034404a56b0f8445c2ef72a4ded35779eb5f9178e1da7df79afb788b3dcdc863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199406093302310$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/223970340?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,2746,2747,26084,27905,27906,52363,54045,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4117466$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8177274$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Econs, Michael J</creatorcontrib><creatorcontrib>Drezner, Marc K</creatorcontrib><title>Tumor-Induced Osteomalacia -- Unveiling a New Hormone</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Phosphate plays a critical part in the regulation of cell metabolism, and phosphate homeostasis is closely regulated in normal humans. Indeed, like serum calcium, serum phosphate is maintained within a narrow range of values, and people with abnormal concentrations may have a predisposition to life-threatening conditions, such as hemolysis, myopathy, hypocalcemia, and nephrocalcinosis.
The principal organ that regulates phosphate homeostasis is the kidney. Regulation is accomplished partly through variation in glomerular filtration of phosphate but primarily through variation in renal tubular reabsorption of phosphate. These variations are detectable within 24 hours after a change in dietary phosphate intake and even . . .</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcification</subject><subject>Chromosomes</subject><subject>Dietary intake</subject><subject>Diseases of the osteoarticular system</subject><subject>Homeostasis</subject><subject>Hormones</subject><subject>Humans</subject><subject>Hypophosphatemia - genetics</subject><subject>Hypophosphatemia - metabolism</subject><subject>Kidney - metabolism</subject><subject>Kidneys</subject><subject>Medical sciences</subject><subject>Metabolism</subject><subject>Neoplasms - complications</subject><subject>Osteomalacia</subject><subject>Osteomalacia - etiology</subject><subject>Osteomalacia - metabolism</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Phosphates - metabolism</subject><subject>Rodents</subject><subject>Tumors</subject><subject>Vitamin D</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kMFKAzEQhoMotVafQIRFxYusJptkkxylVKvU9tKel2ySlS2bbE26im9vSksPos5lYOabmX9-AM4RvEOQ5vfT0csrEoLAHAqMYYYRPAB9RDFOSSwegj6EGU8JE_gYnISwhDEQET3Q44ixjJE-oPPOtj59drpTRiezsDatlY1UtUzSNFm4D1M3tXtLZDI1n8m49bZ15hQcVbIJ5myXB2DxOJoPx-lk9vQ8fJikimZ0nSqIoxAiaV7CihNCVWYqlkmijcaUMWFKWgnEuEFaMl0xIauScV5irbTiOR6Am-3elW_fOxPWha2DMk0jnWm7ULCccEExi-DlD3DZdt5FbUWWYcGiEBihq78gJDjmCEcHI4W3lPJtCN5UxcrXVvqvAsFi43vxi-9x6mK3uyut0fuZndGxf73ry6BkU3npVB32GEGIkXzz8O0WszYUziztv0e_AbErkxM</recordid><startdate>19940609</startdate><enddate>19940609</enddate><creator>Econs, Michael J</creator><creator>Drezner, Marc K</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19940609</creationdate><title>Tumor-Induced Osteomalacia -- Unveiling a New Hormone</title><author>Econs, Michael J ; Drezner, Marc K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-c034404a56b0f8445c2ef72a4ded35779eb5f9178e1da7df79afb788b3dcdc863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcification</topic><topic>Chromosomes</topic><topic>Dietary intake</topic><topic>Diseases of the osteoarticular system</topic><topic>Homeostasis</topic><topic>Hormones</topic><topic>Humans</topic><topic>Hypophosphatemia - genetics</topic><topic>Hypophosphatemia - metabolism</topic><topic>Kidney - metabolism</topic><topic>Kidneys</topic><topic>Medical sciences</topic><topic>Metabolism</topic><topic>Neoplasms - complications</topic><topic>Osteomalacia</topic><topic>Osteomalacia - etiology</topic><topic>Osteomalacia - metabolism</topic><topic>Osteoporosis. 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Paget disease</topic><topic>Pathogenesis</topic><topic>Patients</topic><topic>Phosphates - metabolism</topic><topic>Rodents</topic><topic>Tumors</topic><topic>Vitamin D</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Econs, Michael J</creatorcontrib><creatorcontrib>Drezner, Marc K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Econs, Michael J</au><au>Drezner, Marc K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tumor-Induced Osteomalacia -- Unveiling a New Hormone</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1994-06-09</date><risdate>1994</risdate><volume>330</volume><issue>23</issue><spage>1679</spage><epage>1681</epage><pages>1679-1681</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>Phosphate plays a critical part in the regulation of cell metabolism, and phosphate homeostasis is closely regulated in normal humans. Indeed, like serum calcium, serum phosphate is maintained within a narrow range of values, and people with abnormal concentrations may have a predisposition to life-threatening conditions, such as hemolysis, myopathy, hypocalcemia, and nephrocalcinosis.
The principal organ that regulates phosphate homeostasis is the kidney. Regulation is accomplished partly through variation in glomerular filtration of phosphate but primarily through variation in renal tubular reabsorption of phosphate. These variations are detectable within 24 hours after a change in dietary phosphate intake and even . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>8177274</pmid><doi>10.1056/NEJM199406093302310</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1994-06, Vol.330 (23), p.1679-1681 |
| issn | 0028-4793 1533-4406 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Animals Biological and medical sciences Calcification Chromosomes Dietary intake Diseases of the osteoarticular system Homeostasis Hormones Humans Hypophosphatemia - genetics Hypophosphatemia - metabolism Kidney - metabolism Kidneys Medical sciences Metabolism Neoplasms - complications Osteomalacia Osteomalacia - etiology Osteomalacia - metabolism Osteoporosis. Osteomalacia. Paget disease Pathogenesis Patients Phosphates - metabolism Rodents Tumors Vitamin D |
| title | Tumor-Induced Osteomalacia -- Unveiling a New Hormone |
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