Selenite induction of DNA strand breaks and apoptosis in mouse leukemic L1210 cells

The effects of selenite on DNA integrity, cell viability, and long-term proliferative potential of mouse leukemic L1210 cells were examined in this study. Selenite treatment resulted in concentration-dependent increases in DNA single-strand breaks and double-strand breaks, as detected by a modified...

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Veröffentlicht in:	Biochemical pharmacology 1994-04, Vol.47 (9), p.1531-1535
Hauptverfasser:	Lu, Junxuan, Kaeck, Mark, Jiang, Cheng, Wilson, Adrian C., Thompson, Henry J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Apoptosis Aurintricarboxylic Acid - pharmacology Biological and medical sciences Cell Survival Colony-Forming Units Assay DNA Damage DNA strand breaks DNA, Single-Stranded - drug effects DNA, Single-Stranded - ultrastructure Endonucleases - antagonists & inhibitors General aspects Leukemia L1210 leukemic cells Medical sciences Mice Pharmacology. Drug treatments selenium Selenium - analysis Sodium Selenite - pharmacology Sulfates - pharmacology Tumor Cells, Cultured Zinc Compounds - pharmacology Zinc Sulfate
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