Stimulation of Postsynaptic and Inhibition of Presynaptic Adenylyl Cyclase Activity by Metabotropic Glutamate: Receptor Activation

: To determine the subcellular distribution of cyclic AMP‐coupled metabotropic glutamate receptors (mGluRs), the effects of glutamate agonists on adenylyl cyclase activity were examined using two hippocampal membrane preparations. These were synaptosomes (SY), which are composed of presynaptic termi...

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Veröffentlicht in:	Journal of neurochemistry 1994-06, Vol.62 (6), p.2316-2324
Hauptverfasser:	Musgrave, Melinda A., Madigan, Maureen A., Bennett, Brian M., Goh, Joanne W.
Format:	Artikel
Sprache:	eng
Schlagworte:	1S,3R‐1‐Aminocyclopentane‐1,3‐dicarboxylic acid Adenylyl cyclase Adenylyl Cyclase Inhibitors Adenylyl Cyclases - metabolism Alanine - analogs & derivatives Alanine - pharmacology Animals Biochemistry and metabolism Biological and medical sciences Central nervous system Enzyme Activation Fundamental and applied biological sciences. Psychology Glutamates - physiology Glutamic Acid Hippocampus Male Metabotropic glutamate receptor Presynaptic Terminals - enzymology Rats Rats, Wistar Receptors, Metabotropic Glutamate - antagonists & inhibitors Receptors, Metabotropic Glutamate - metabolism Synapses - enzymology Synaptoneurosomes Synaptosomes Synaptosomes - enzymology Vertebrates: nervous system and sense organs
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