Frequent detection of codon 877 mutation in the androgen receptor gene in advanced prostate cancers

Prostatic tissue specimens derived from transurethral resections of patients with metastatic prostate cancer were analyzed for genetic alterations in the hormone-binding domain of the androgen receptor (AR) gene. Direct sequencing of the polymerase chain reaction-derived DNAs of 6 of 24 specimens re...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1994-06, Vol.54 (11), p.2861-2864
Hauptverfasser:	GADDIPATI, J. P, MCLEOD, D. G, HEIDENBERG, H. B, SESTERHENN, I. A, FINGER, M. J, MOUL, J. W, SHIV SRIVASTAVA
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Codon - chemistry Codon - genetics DNA, Neoplasm - analysis Humans Male Medical sciences Molecular Sequence Data Nephrology. Urinary tract diseases Point Mutation - genetics Prostatic Neoplasms - chemistry Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Receptors, Androgen - chemistry Receptors, Androgen - genetics Sequence Analysis, DNA Tumor Cells, Cultured Tumors of the urinary system Urinary tract. Prostate gland
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