How safe is coronary bypass surgery in the elderly patient? Analysis of 111 patients aged 75 years or more and 2939 patients younger than 75 years undergoing coronary artery bypass grafting in a private hospital

AIM AND METHODSData from patients younger than 75 years (group I, n = 2939) and patients aged 75 years or older (group II, n =111) who underwent isolated coronary artery bypass grafting (CABG) during a 9-year period (January 1984 to April 1993) were analyzed to determine comparative risk factors for...

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Veröffentlicht in:Coronary artery disease 1994-02, Vol.5 (2), p.169-174
Hauptverfasser: Christenson, Jan T, Schmuziger, Martin, Maurice, Jean, Simonet, Francois, Velebit, Vladimir
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container_end_page 174
container_issue 2
container_start_page 169
container_title Coronary artery disease
container_volume 5
creator Christenson, Jan T
Schmuziger, Martin
Maurice, Jean
Simonet, Francois
Velebit, Vladimir
description AIM AND METHODSData from patients younger than 75 years (group I, n = 2939) and patients aged 75 years or older (group II, n =111) who underwent isolated coronary artery bypass grafting (CABG) during a 9-year period (January 1984 to April 1993) were analyzed to determine comparative risk factors for morbidity, early and late survival, and functional outcome. RESULTSTraditional risk factors (hypertension, hyperlipidemia, diabetes mellitus, and smoking) were significantly more prevalent in group II. The number of patients in New York Heart Association (NYHA) functional classes 3 and 4 before surgery was also significantly higher in group II (P< 0.001), but emergency operations were equally distributed between the groups. Lett main-stem stenosis was more frequent in group II patients (P< 0.01), while the number of vessels involved and pre-operative left ventricular function did not differ.Both groups underwent a mean of 4.5 grafts. Internal mammary grafts were placed in 48.4% (1422/2939) in group I and 19.8% (22/111) in group II (P< 0.001). The overall pen-operative mortality rate did not differ between the groups (2.9% for group I and 2.7% for group II). Non-fatal peri-operative myocardial infarction, ventricular arrhythmias, postextracorporeal circulation disorientation, and temporary renal insufficiency were more prevalent in group II patients (all P< 0.05). Emergency operations and re-operative CABG increased the pen-operative mortality in both groups. The 3-year survival rate was 93% and the 3-year cardiac event-free rate was 88% for the group II patients. Most of the elderly patients (98%) were in NYHA functional classes 1 and 2 at the end of the follow-up. CONCLUSIONSEven if elderly patients have a slightly higher postoperative morbidity than younger patients, and an increased mortality if operated upon in an emergency, long-term survival and freedom from cardiac events are excellent and justify the continued performance of CABG in patients aged 75 years of age or more.
doi_str_mv 10.1097/00019501-199402000-00011
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Analysis of 111 patients aged 75 years or more and 2939 patients younger than 75 years undergoing coronary artery bypass grafting in a private hospital</title><source>MEDLINE</source><source>Journals@Ovid Ovid Autoload</source><creator>Christenson, Jan T ; Schmuziger, Martin ; Maurice, Jean ; Simonet, Francois ; Velebit, Vladimir</creator><creatorcontrib>Christenson, Jan T ; Schmuziger, Martin ; Maurice, Jean ; Simonet, Francois ; Velebit, Vladimir</creatorcontrib><description>AIM AND METHODSData from patients younger than 75 years (group I, n = 2939) and patients aged 75 years or older (group II, n =111) who underwent isolated coronary artery bypass grafting (CABG) during a 9-year period (January 1984 to April 1993) were analyzed to determine comparative risk factors for morbidity, early and late survival, and functional outcome. RESULTSTraditional risk factors (hypertension, hyperlipidemia, diabetes mellitus, and smoking) were significantly more prevalent in group II. The number of patients in New York Heart Association (NYHA) functional classes 3 and 4 before surgery was also significantly higher in group II (P&lt; 0.001), but emergency operations were equally distributed between the groups. Lett main-stem stenosis was more frequent in group II patients (P&lt; 0.01), while the number of vessels involved and pre-operative left ventricular function did not differ.Both groups underwent a mean of 4.5 grafts. Internal mammary grafts were placed in 48.4% (1422/2939) in group I and 19.8% (22/111) in group II (P&lt; 0.001). The overall pen-operative mortality rate did not differ between the groups (2.9% for group I and 2.7% for group II). Non-fatal peri-operative myocardial infarction, ventricular arrhythmias, postextracorporeal circulation disorientation, and temporary renal insufficiency were more prevalent in group II patients (all P&lt; 0.05). Emergency operations and re-operative CABG increased the pen-operative mortality in both groups. The 3-year survival rate was 93% and the 3-year cardiac event-free rate was 88% for the group II patients. Most of the elderly patients (98%) were in NYHA functional classes 1 and 2 at the end of the follow-up. CONCLUSIONSEven if elderly patients have a slightly higher postoperative morbidity than younger patients, and an increased mortality if operated upon in an emergency, long-term survival and freedom from cardiac events are excellent and justify the continued performance of CABG in patients aged 75 years of age or more.</description><identifier>ISSN: 0954-6928</identifier><identifier>EISSN: 1473-5830</identifier><identifier>DOI: 10.1097/00019501-199402000-00011</identifier><identifier>PMID: 8180747</identifier><language>eng</language><publisher>England: Lippincott-Raven Publishers</publisher><subject>Activities of Daily Living ; Acute Kidney Injury - epidemiology ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Arrhythmias, Cardiac - epidemiology ; Coronary Artery Bypass - adverse effects ; Coronary Artery Bypass - methods ; Coronary Artery Bypass - mortality ; Coronary Artery Bypass - statistics &amp; numerical data ; Coronary Disease - pathology ; Coronary Disease - surgery ; Endarterectomy ; Female ; Follow-Up Studies ; Hospitals, Private ; Humans ; Internal Mammary-Coronary Artery Anastomosis ; Male ; Middle Aged ; Myocardial Infarction - epidemiology ; Reoperation - statistics &amp; numerical data ; Risk Factors ; Survival Rate ; Switzerland - epidemiology ; Treatment Outcome</subject><ispartof>Coronary artery disease, 1994-02, Vol.5 (2), p.169-174</ispartof><rights>Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3551-4dcf4073001b4afe9970ca2ccc443d1c6474d64cfb54e026b221167fc3df6323</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8180747$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Christenson, Jan T</creatorcontrib><creatorcontrib>Schmuziger, Martin</creatorcontrib><creatorcontrib>Maurice, Jean</creatorcontrib><creatorcontrib>Simonet, Francois</creatorcontrib><creatorcontrib>Velebit, Vladimir</creatorcontrib><title>How safe is coronary bypass surgery in the elderly patient? Analysis of 111 patients aged 75 years or more and 2939 patients younger than 75 years undergoing coronary artery bypass grafting in a private hospital</title><title>Coronary artery disease</title><addtitle>Coron Artery Dis</addtitle><description>AIM AND METHODSData from patients younger than 75 years (group I, n = 2939) and patients aged 75 years or older (group II, n =111) who underwent isolated coronary artery bypass grafting (CABG) during a 9-year period (January 1984 to April 1993) were analyzed to determine comparative risk factors for morbidity, early and late survival, and functional outcome. RESULTSTraditional risk factors (hypertension, hyperlipidemia, diabetes mellitus, and smoking) were significantly more prevalent in group II. The number of patients in New York Heart Association (NYHA) functional classes 3 and 4 before surgery was also significantly higher in group II (P&lt; 0.001), but emergency operations were equally distributed between the groups. Lett main-stem stenosis was more frequent in group II patients (P&lt; 0.01), while the number of vessels involved and pre-operative left ventricular function did not differ.Both groups underwent a mean of 4.5 grafts. Internal mammary grafts were placed in 48.4% (1422/2939) in group I and 19.8% (22/111) in group II (P&lt; 0.001). The overall pen-operative mortality rate did not differ between the groups (2.9% for group I and 2.7% for group II). Non-fatal peri-operative myocardial infarction, ventricular arrhythmias, postextracorporeal circulation disorientation, and temporary renal insufficiency were more prevalent in group II patients (all P&lt; 0.05). Emergency operations and re-operative CABG increased the pen-operative mortality in both groups. The 3-year survival rate was 93% and the 3-year cardiac event-free rate was 88% for the group II patients. Most of the elderly patients (98%) were in NYHA functional classes 1 and 2 at the end of the follow-up. CONCLUSIONSEven if elderly patients have a slightly higher postoperative morbidity than younger patients, and an increased mortality if operated upon in an emergency, long-term survival and freedom from cardiac events are excellent and justify the continued performance of CABG in patients aged 75 years of age or more.</description><subject>Activities of Daily Living</subject><subject>Acute Kidney Injury - epidemiology</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arrhythmias, Cardiac - epidemiology</subject><subject>Coronary Artery Bypass - adverse effects</subject><subject>Coronary Artery Bypass - methods</subject><subject>Coronary Artery Bypass - mortality</subject><subject>Coronary Artery Bypass - statistics &amp; numerical data</subject><subject>Coronary Disease - pathology</subject><subject>Coronary Disease - surgery</subject><subject>Endarterectomy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Hospitals, Private</subject><subject>Humans</subject><subject>Internal Mammary-Coronary Artery Anastomosis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - epidemiology</subject><subject>Reoperation - statistics &amp; numerical data</subject><subject>Risk Factors</subject><subject>Survival Rate</subject><subject>Switzerland - epidemiology</subject><subject>Treatment Outcome</subject><issn>0954-6928</issn><issn>1473-5830</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UsFu1DAQtSpQWUo_AWlO3FLs2I7jE6oqaJEqcek9cpxJNuC1g52wynf2h_Cy2-6JkzXz3sy8mWdCgNEbRrX6TCllWlJWMK0FLXNYHFLsgmyYULyQNadvyIZqKYpKl_U78j6ln5khpJKX5LJmNVVCbcjzQ9hDMj3CmMCGGLyJK7TrZFKCtMQBczh6mLcI6DqMboXJzCP6-QvceuPWlAtDD4yxFyCBGbADJWFFEzMaYRcigvEdlJrrM28Ni88Tcnfjz_zF5zlDGP1wVmTijGdhQzT9fMCzMgNTHP-YGWEb0jTOxn0gb3vjEl6f3ivy9O3r091D8fjj_vvd7WNhuZSsEJ3tBVU8X6UV-QJaK2pNaa0VgnfMVkKJrhK2b6VAWlZtWTJWqd7yrq94ya_Ip2PbKYbfC6a52Y3JonPGY1hSoypRS8ZpJtZHoo0hpYh9kxXv8lYNo83BzubFzubVzn8plks_nmYs7Q6718KTfxkXR3wfXD5Q-uWWPcZmi8bN2-Z_v4T_BS0zrWw</recordid><startdate>199402</startdate><enddate>199402</enddate><creator>Christenson, Jan T</creator><creator>Schmuziger, Martin</creator><creator>Maurice, Jean</creator><creator>Simonet, Francois</creator><creator>Velebit, Vladimir</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199402</creationdate><title>How safe is coronary bypass surgery in the elderly patient? Analysis of 111 patients aged 75 years or more and 2939 patients younger than 75 years undergoing coronary artery bypass grafting in a private hospital</title><author>Christenson, Jan T ; Schmuziger, Martin ; Maurice, Jean ; Simonet, Francois ; Velebit, Vladimir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3551-4dcf4073001b4afe9970ca2ccc443d1c6474d64cfb54e026b221167fc3df6323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Activities of Daily Living</topic><topic>Acute Kidney Injury - epidemiology</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arrhythmias, Cardiac - epidemiology</topic><topic>Coronary Artery Bypass - adverse effects</topic><topic>Coronary Artery Bypass - methods</topic><topic>Coronary Artery Bypass - mortality</topic><topic>Coronary Artery Bypass - statistics &amp; numerical data</topic><topic>Coronary Disease - pathology</topic><topic>Coronary Disease - surgery</topic><topic>Endarterectomy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Hospitals, Private</topic><topic>Humans</topic><topic>Internal Mammary-Coronary Artery Anastomosis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - epidemiology</topic><topic>Reoperation - statistics &amp; numerical data</topic><topic>Risk Factors</topic><topic>Survival Rate</topic><topic>Switzerland - epidemiology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Christenson, Jan T</creatorcontrib><creatorcontrib>Schmuziger, Martin</creatorcontrib><creatorcontrib>Maurice, Jean</creatorcontrib><creatorcontrib>Simonet, Francois</creatorcontrib><creatorcontrib>Velebit, Vladimir</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Coronary artery disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Christenson, Jan T</au><au>Schmuziger, Martin</au><au>Maurice, Jean</au><au>Simonet, Francois</au><au>Velebit, Vladimir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>How safe is coronary bypass surgery in the elderly patient? Analysis of 111 patients aged 75 years or more and 2939 patients younger than 75 years undergoing coronary artery bypass grafting in a private hospital</atitle><jtitle>Coronary artery disease</jtitle><addtitle>Coron Artery Dis</addtitle><date>1994-02</date><risdate>1994</risdate><volume>5</volume><issue>2</issue><spage>169</spage><epage>174</epage><pages>169-174</pages><issn>0954-6928</issn><eissn>1473-5830</eissn><abstract>AIM AND METHODSData from patients younger than 75 years (group I, n = 2939) and patients aged 75 years or older (group II, n =111) who underwent isolated coronary artery bypass grafting (CABG) during a 9-year period (January 1984 to April 1993) were analyzed to determine comparative risk factors for morbidity, early and late survival, and functional outcome. RESULTSTraditional risk factors (hypertension, hyperlipidemia, diabetes mellitus, and smoking) were significantly more prevalent in group II. The number of patients in New York Heart Association (NYHA) functional classes 3 and 4 before surgery was also significantly higher in group II (P&lt; 0.001), but emergency operations were equally distributed between the groups. Lett main-stem stenosis was more frequent in group II patients (P&lt; 0.01), while the number of vessels involved and pre-operative left ventricular function did not differ.Both groups underwent a mean of 4.5 grafts. Internal mammary grafts were placed in 48.4% (1422/2939) in group I and 19.8% (22/111) in group II (P&lt; 0.001). The overall pen-operative mortality rate did not differ between the groups (2.9% for group I and 2.7% for group II). Non-fatal peri-operative myocardial infarction, ventricular arrhythmias, postextracorporeal circulation disorientation, and temporary renal insufficiency were more prevalent in group II patients (all P&lt; 0.05). Emergency operations and re-operative CABG increased the pen-operative mortality in both groups. The 3-year survival rate was 93% and the 3-year cardiac event-free rate was 88% for the group II patients. Most of the elderly patients (98%) were in NYHA functional classes 1 and 2 at the end of the follow-up. CONCLUSIONSEven if elderly patients have a slightly higher postoperative morbidity than younger patients, and an increased mortality if operated upon in an emergency, long-term survival and freedom from cardiac events are excellent and justify the continued performance of CABG in patients aged 75 years of age or more.</abstract><cop>England</cop><pub>Lippincott-Raven Publishers</pub><pmid>8180747</pmid><doi>10.1097/00019501-199402000-00011</doi><tpages>6</tpages></addata></record>
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source MEDLINE; Journals@Ovid Ovid Autoload
subjects Activities of Daily Living
Acute Kidney Injury - epidemiology
Adult
Age Factors
Aged
Aged, 80 and over
Arrhythmias, Cardiac - epidemiology
Coronary Artery Bypass - adverse effects
Coronary Artery Bypass - methods
Coronary Artery Bypass - mortality
Coronary Artery Bypass - statistics & numerical data
Coronary Disease - pathology
Coronary Disease - surgery
Endarterectomy
Female
Follow-Up Studies
Hospitals, Private
Humans
Internal Mammary-Coronary Artery Anastomosis
Male
Middle Aged
Myocardial Infarction - epidemiology
Reoperation - statistics & numerical data
Risk Factors
Survival Rate
Switzerland - epidemiology
Treatment Outcome
title How safe is coronary bypass surgery in the elderly patient? Analysis of 111 patients aged 75 years or more and 2939 patients younger than 75 years undergoing coronary artery bypass grafting in a private hospital
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