Use of Amino Acid Environment-dependent Substitution Tables and Conformational Propensities in Structure Prediction from Aligned Sequences of Homologous Proteins I. Solvent Accessibility Classes

Buried and exposed residues are predicted by composing amino acid substitution patterns and mean propensities for the two solvent accessibility classes with the amino acid residues at equivalent sites in aligned sequences of homologous proteins. In a study of 13 protein families, the accuracy of the...

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Veröffentlicht in:	Journal of molecular biology 1994-05, Vol.238 (5), p.682-692
Hauptverfasser:	Wako, Hiroshi, Blundell, Tom L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acids - chemistry homologous sequences Mathematics Protein Folding protein structure prediction Protein Structure, Secondary Proteins - chemistry Sequence Alignment Sequence Homology, Amino Acid solvent accessibility Solvents substitution tables
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