Radiation-Induced Luminescence in DNA: Evidence for Long-Range Electron Migration
The radiation-induced "in-pulse" luminescence emission from solid DNA containing either metronidazole or a highly electronaffinic 5-nitrofuran in the range 3-2000 (w:w) base pairs per additive molecule has been investigated in vacuo at 293 K using electron pulses of energy below 260 keV. T...
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| Veröffentlicht in: | Radiation Research 1994-06, Vol.138 (3), p.307-311 |
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| container_title | Radiation Research |
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| creator | Al-Kazwini, Akeel T. Adams, Gerald E. O'Neill, Peter Naylor, Matthew A. Fielden, E. Martin |
| description | The radiation-induced "in-pulse" luminescence emission from solid DNA containing either metronidazole or a highly electronaffinic 5-nitrofuran in the range 3-2000 (w:w) base pairs per additive molecule has been investigated in vacuo at 293 K using electron pulses of energy below 260 keV. The luminescence intensity at 450 nm from DNA decreases with increasing content of the additive in the sample and approaches a limiting level at high concentrations of the additives. At these higher concentrations the limiting value represents about 50% of that observed from DNA alone. It is shown that the efficiency of the additives in reducing the luminescence intensity is dependent upon their redox potential $E_{7}^{1}$; this dependence is consistent with these additives acting as electron acceptors. It is concluded that the ability of the electron acceptors to reduce the luminescence is related to the electron affinity of $E_{7}^{1}$ of the acceptors and electron migration distances of at least 300 base pairs are proposed. |
| doi_str_mv | 10.2307/3578677 |
| format | Article |
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Martin</creator><creatorcontrib>Al-Kazwini, Akeel T. ; Adams, Gerald E. ; O'Neill, Peter ; Naylor, Matthew A. ; Fielden, E. Martin</creatorcontrib><description>The radiation-induced "in-pulse" luminescence emission from solid DNA containing either metronidazole or a highly electronaffinic 5-nitrofuran in the range 3-2000 (w:w) base pairs per additive molecule has been investigated in vacuo at 293 K using electron pulses of energy below 260 keV. The luminescence intensity at 450 nm from DNA decreases with increasing content of the additive in the sample and approaches a limiting level at high concentrations of the additives. At these higher concentrations the limiting value represents about 50% of that observed from DNA alone. It is shown that the efficiency of the additives in reducing the luminescence intensity is dependent upon their redox potential $E_{7}^{1}$; this dependence is consistent with these additives acting as electron acceptors. It is concluded that the ability of the electron acceptors to reduce the luminescence is related to the electron affinity of $E_{7}^{1}$ of the acceptors and electron migration distances of at least 300 base pairs are proposed.</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.2307/3578677</identifier><identifier>PMID: 8184004</identifier><identifier>CODEN: RAREAE</identifier><language>eng</language><publisher>Oak Brook, Il: Radiation Research Society</publisher><subject>AFFINITY ; Animal migration behavior ; Biological and medical sciences ; BIOLOGICAL RADIATION EFFECTS ; BIOLOGY AND MEDICINE, APPLIED STUDIES ; BIOLOGY AND MEDICINE, BASIC STUDIES ; DNA ; DNA - radiation effects ; Electron affinity ; Electron paramagnetic resonance ; ELECTRON TRANSFER ; Electrons ; Fundamental and applied biological sciences. Psychology ; Hypoxia ; Ionization ; Irradiation ; LUMINESCENCE ; Luminescent Measurements ; METRONIDAZOLE ; Metronidazole - chemistry ; MIGRATION LENGTH ; Misonidazole - chemistry ; Molecular biophysics ; Molecules ; Nitrofurans - chemistry ; Oxidation-Reduction ; PULSES ; Radiation-biomolecule interaction ; Radiochemistry ; REDOX POTENTIAL ; Space life sciences</subject><ispartof>Radiation Research, 1994-06, Vol.138 (3), p.307-311</ispartof><rights>Copyright 1994 The Radiation Research Society</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-980afcca9d7c69a2da01ef04b09038f3754958f156b030aea63ca775fec690523</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3578677$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3578677$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,881,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4266132$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8184004$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/79309$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Al-Kazwini, Akeel T.</creatorcontrib><creatorcontrib>Adams, Gerald E.</creatorcontrib><creatorcontrib>O'Neill, Peter</creatorcontrib><creatorcontrib>Naylor, Matthew A.</creatorcontrib><creatorcontrib>Fielden, E. Martin</creatorcontrib><title>Radiation-Induced Luminescence in DNA: Evidence for Long-Range Electron Migration</title><title>Radiation Research</title><addtitle>Radiat Res</addtitle><description>The radiation-induced "in-pulse" luminescence emission from solid DNA containing either metronidazole or a highly electronaffinic 5-nitrofuran in the range 3-2000 (w:w) base pairs per additive molecule has been investigated in vacuo at 293 K using electron pulses of energy below 260 keV. The luminescence intensity at 450 nm from DNA decreases with increasing content of the additive in the sample and approaches a limiting level at high concentrations of the additives. At these higher concentrations the limiting value represents about 50% of that observed from DNA alone. It is shown that the efficiency of the additives in reducing the luminescence intensity is dependent upon their redox potential $E_{7}^{1}$; this dependence is consistent with these additives acting as electron acceptors. It is concluded that the ability of the electron acceptors to reduce the luminescence is related to the electron affinity of $E_{7}^{1}$ of the acceptors and electron migration distances of at least 300 base pairs are proposed.</description><subject>AFFINITY</subject><subject>Animal migration behavior</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL RADIATION EFFECTS</subject><subject>BIOLOGY AND MEDICINE, APPLIED STUDIES</subject><subject>BIOLOGY AND MEDICINE, BASIC STUDIES</subject><subject>DNA</subject><subject>DNA - radiation effects</subject><subject>Electron affinity</subject><subject>Electron paramagnetic resonance</subject><subject>ELECTRON TRANSFER</subject><subject>Electrons</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypoxia</subject><subject>Ionization</subject><subject>Irradiation</subject><subject>LUMINESCENCE</subject><subject>Luminescent Measurements</subject><subject>METRONIDAZOLE</subject><subject>Metronidazole - chemistry</subject><subject>MIGRATION LENGTH</subject><subject>Misonidazole - chemistry</subject><subject>Molecular biophysics</subject><subject>Molecules</subject><subject>Nitrofurans - chemistry</subject><subject>Oxidation-Reduction</subject><subject>PULSES</subject><subject>Radiation-biomolecule interaction</subject><subject>Radiochemistry</subject><subject>REDOX POTENTIAL</subject><subject>Space life sciences</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E9PwyAYBnBiNHNO4ycw6cHoqfq2QAFvy5x_kqlx0XPDKExMBwqtid_eujXz5InA-8sDPAgdZ3CRY2CXmDJeMLaDhpnAPKUEyC4aAmCcMsrZPjqI8R26fVaIARrwjBMAMkTPc1lZ2Vjv0ntXtUpXyaxdWaej0k7pxLrk-nF8lUy_bLU-MD4kM--W6Vy6pU6mtVZN8C55sMuwzjlEe0bWUR_16wi93kxfJnfp7On2fjKepQpT0aSCgzRKSVExVQiZVxIybYAsQADmBjNKBOUmo8UCMEgtC6wkY9TojgPN8Qglm1wfG1tGZRut3pR3rntQyQQG0ZGzDfkI_rPVsSlXtvtXXUunfRtLVhCeE0E6eL6BKvgYgzblR7ArGb7LDMrffsu-306e9JHtYqWrresL7ean_VxGJWsTpFM2bhnJiyLD-R97j40P_972A9LZiu0</recordid><startdate>19940601</startdate><enddate>19940601</enddate><creator>Al-Kazwini, Akeel T.</creator><creator>Adams, Gerald E.</creator><creator>O'Neill, Peter</creator><creator>Naylor, Matthew A.</creator><creator>Fielden, E. Martin</creator><general>Radiation Research Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>19940601</creationdate><title>Radiation-Induced Luminescence in DNA: Evidence for Long-Range Electron Migration</title><author>Al-Kazwini, Akeel T. ; Adams, Gerald E. ; O'Neill, Peter ; Naylor, Matthew A. ; Fielden, E. Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-980afcca9d7c69a2da01ef04b09038f3754958f156b030aea63ca775fec690523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>AFFINITY</topic><topic>Animal migration behavior</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL RADIATION EFFECTS</topic><topic>BIOLOGY AND MEDICINE, APPLIED STUDIES</topic><topic>BIOLOGY AND MEDICINE, BASIC STUDIES</topic><topic>DNA</topic><topic>DNA - radiation effects</topic><topic>Electron affinity</topic><topic>Electron paramagnetic resonance</topic><topic>ELECTRON TRANSFER</topic><topic>Electrons</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypoxia</topic><topic>Ionization</topic><topic>Irradiation</topic><topic>LUMINESCENCE</topic><topic>Luminescent Measurements</topic><topic>METRONIDAZOLE</topic><topic>Metronidazole - chemistry</topic><topic>MIGRATION LENGTH</topic><topic>Misonidazole - chemistry</topic><topic>Molecular biophysics</topic><topic>Molecules</topic><topic>Nitrofurans - chemistry</topic><topic>Oxidation-Reduction</topic><topic>PULSES</topic><topic>Radiation-biomolecule interaction</topic><topic>Radiochemistry</topic><topic>REDOX POTENTIAL</topic><topic>Space life sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al-Kazwini, Akeel T.</creatorcontrib><creatorcontrib>Adams, Gerald E.</creatorcontrib><creatorcontrib>O'Neill, Peter</creatorcontrib><creatorcontrib>Naylor, Matthew A.</creatorcontrib><creatorcontrib>Fielden, E. 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Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiation-Induced Luminescence in DNA: Evidence for Long-Range Electron Migration</atitle><jtitle>Radiation Research</jtitle><addtitle>Radiat Res</addtitle><date>1994-06-01</date><risdate>1994</risdate><volume>138</volume><issue>3</issue><spage>307</spage><epage>311</epage><pages>307-311</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><coden>RAREAE</coden><abstract>The radiation-induced "in-pulse" luminescence emission from solid DNA containing either metronidazole or a highly electronaffinic 5-nitrofuran in the range 3-2000 (w:w) base pairs per additive molecule has been investigated in vacuo at 293 K using electron pulses of energy below 260 keV. The luminescence intensity at 450 nm from DNA decreases with increasing content of the additive in the sample and approaches a limiting level at high concentrations of the additives. At these higher concentrations the limiting value represents about 50% of that observed from DNA alone. It is shown that the efficiency of the additives in reducing the luminescence intensity is dependent upon their redox potential $E_{7}^{1}$; this dependence is consistent with these additives acting as electron acceptors. It is concluded that the ability of the electron acceptors to reduce the luminescence is related to the electron affinity of $E_{7}^{1}$ of the acceptors and electron migration distances of at least 300 base pairs are proposed.</abstract><cop>Oak Brook, Il</cop><pub>Radiation Research Society</pub><pmid>8184004</pmid><doi>10.2307/3578677</doi><tpages>5</tpages></addata></record> |
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| ispartof | Radiation Research, 1994-06, Vol.138 (3), p.307-311 |
| issn | 0033-7587 1938-5404 |
| language | eng |
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| source | Jstor Complete Legacy; MEDLINE |
| subjects | AFFINITY Animal migration behavior Biological and medical sciences BIOLOGICAL RADIATION EFFECTS BIOLOGY AND MEDICINE, APPLIED STUDIES BIOLOGY AND MEDICINE, BASIC STUDIES DNA DNA - radiation effects Electron affinity Electron paramagnetic resonance ELECTRON TRANSFER Electrons Fundamental and applied biological sciences. Psychology Hypoxia Ionization Irradiation LUMINESCENCE Luminescent Measurements METRONIDAZOLE Metronidazole - chemistry MIGRATION LENGTH Misonidazole - chemistry Molecular biophysics Molecules Nitrofurans - chemistry Oxidation-Reduction PULSES Radiation-biomolecule interaction Radiochemistry REDOX POTENTIAL Space life sciences |
| title | Radiation-Induced Luminescence in DNA: Evidence for Long-Range Electron Migration |
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