Neuropathology of the near-term and midgestation ovine fetal brain after sustained in utero hypoxemia
OBJECTIVE: The neuropathologic mechanisms of the ovine fetal brain in response to several hours of sustained hypoxemia with variable degrees of metabolic acidemia was investigated in both the preterm and near-term ovine fetus. STUDY DESIGN: Three groups of fetuses were studied in each of the near-te...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1994-05, Vol.170 (5), p.1425-1432 |
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| container_issue | 5 |
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| container_title | American journal of obstetrics and gynecology |
| container_volume | 170 |
| creator | Penning, Donald H. Grafe, Marjorie R. Hammond, Robert Matsuda, Yoshio Patrick, John Richardson, Bryan |
| description | OBJECTIVE: The neuropathologic mechanisms of the ovine fetal brain in response to several hours of sustained hypoxemia with variable degrees of metabolic acidemia was investigated in both the preterm and near-term ovine fetus.
STUDY DESIGN: Three groups of fetuses were studied in each of the near-term and midgestation groups: a hypoxic group, a control group, and an uninstrumented control group. Histopathologic studies were performed after a 40-hour recovery period after experimentation.
RESULTS: Pathologic findings consisted of predominately white matter damage with some adjacent cortical necrosis but no selective neuronal injury. In the near-term group the hypoxia group fetuses demonstrated significantly higher white matter injury scores than did control group fetuses (p < 0.05). Periventricular white matter injury was the predominant pattern seen in the midgestation group.
CONCLUSIONS: In spite of normalization of biophysical and biochemical parameters after hypoxemia both midgestation and near-term fetuses sustained pathologic changes. Presence or extent of injury did not correlate with the degree of hypoxemia or metabolic acidosis achieved. |
| doi_str_mv | 10.1016/S0002-9378(13)90484-1 |
| format | Article |
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STUDY DESIGN: Three groups of fetuses were studied in each of the near-term and midgestation groups: a hypoxic group, a control group, and an uninstrumented control group. Histopathologic studies were performed after a 40-hour recovery period after experimentation.
RESULTS: Pathologic findings consisted of predominately white matter damage with some adjacent cortical necrosis but no selective neuronal injury. In the near-term group the hypoxia group fetuses demonstrated significantly higher white matter injury scores than did control group fetuses (p < 0.05). Periventricular white matter injury was the predominant pattern seen in the midgestation group.
CONCLUSIONS: In spite of normalization of biophysical and biochemical parameters after hypoxemia both midgestation and near-term fetuses sustained pathologic changes. Presence or extent of injury did not correlate with the degree of hypoxemia or metabolic acidosis achieved.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/S0002-9378(13)90484-1</identifier><identifier>PMID: 8178885</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Elsevier Inc</publisher><subject>Acidosis - complications ; Animals ; Biological and medical sciences ; Brain - pathology ; Brain Diseases - etiology ; Brain Diseases - pathology ; Cerebral palsy ; development ; Diseases of mother, fetus and pregnancy ; Female ; Fetal Blood - chemistry ; Fetal Diseases - etiology ; Fetal Diseases - pathology ; Gestational Age ; Gynecology. Andrology. Obstetrics ; hypoxia ; Hypoxia - complications ; Medical sciences ; Necrosis ; ovine fetus ; periventricular leukomalacia ; Pregnancy ; Pregnancy. Fetus. Placenta ; Sheep</subject><ispartof>American journal of obstetrics and gynecology, 1994-05, Vol.170 (5), p.1425-1432</ispartof><rights>1994 Mosby-Year Book, Inc.</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c321t-10fc26f9213eb4d9fbe104db9873ede807829ad2e26384cb5e5d394443b06cdd3</citedby><cites>FETCH-LOGICAL-c321t-10fc26f9213eb4d9fbe104db9873ede807829ad2e26384cb5e5d394443b06cdd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0002-9378(13)90484-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4155056$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8178885$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Penning, Donald H.</creatorcontrib><creatorcontrib>Grafe, Marjorie R.</creatorcontrib><creatorcontrib>Hammond, Robert</creatorcontrib><creatorcontrib>Matsuda, Yoshio</creatorcontrib><creatorcontrib>Patrick, John</creatorcontrib><creatorcontrib>Richardson, Bryan</creatorcontrib><title>Neuropathology of the near-term and midgestation ovine fetal brain after sustained in utero hypoxemia</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>OBJECTIVE: The neuropathologic mechanisms of the ovine fetal brain in response to several hours of sustained hypoxemia with variable degrees of metabolic acidemia was investigated in both the preterm and near-term ovine fetus.
STUDY DESIGN: Three groups of fetuses were studied in each of the near-term and midgestation groups: a hypoxic group, a control group, and an uninstrumented control group. Histopathologic studies were performed after a 40-hour recovery period after experimentation.
RESULTS: Pathologic findings consisted of predominately white matter damage with some adjacent cortical necrosis but no selective neuronal injury. In the near-term group the hypoxia group fetuses demonstrated significantly higher white matter injury scores than did control group fetuses (p < 0.05). Periventricular white matter injury was the predominant pattern seen in the midgestation group.
CONCLUSIONS: In spite of normalization of biophysical and biochemical parameters after hypoxemia both midgestation and near-term fetuses sustained pathologic changes. Presence or extent of injury did not correlate with the degree of hypoxemia or metabolic acidosis achieved.</description><subject>Acidosis - complications</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Brain Diseases - etiology</subject><subject>Brain Diseases - pathology</subject><subject>Cerebral palsy</subject><subject>development</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Fetal Blood - chemistry</subject><subject>Fetal Diseases - etiology</subject><subject>Fetal Diseases - pathology</subject><subject>Gestational Age</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>hypoxia</subject><subject>Hypoxia - complications</subject><subject>Medical sciences</subject><subject>Necrosis</subject><subject>ovine fetus</subject><subject>periventricular leukomalacia</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Sheep</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhi3Uii5LfwKSD1UFh7T-SmKfEEJAK6FyKD1bjj1mjZJ4sRPE_nu87GqvPdme9_HM6EHojJIflNDm519CCKsUb-U55ReKCCkqeoQWlKi2amQjP6HFAfmCTnJ-3j6ZYsfoWNJWSlkvEPyBOcW1mVaxj08bHD2eVoBHMKmaIA3YjA4PwT1BnswU4ojjaxgBe5hMj7tkwoiNLyTOcyFK5HApzaUS8Wqzjm8wBHOKPnvTZ_i6P5fo3-3N4_Wv6v7h7vf11X1lOaNTRYm3rPGKUQ6dcMp3QIlwnZItBweStJIp4xiwhkthuxpqx5UQgneksc7xJfq-67tO8WUuK-shZAt9b0aIc9ZtIyTlpClgvQNtijkn8HqdwmDSRlOit3r1h169dacp1x96y2WJzvYD5m4Ad_i191nyb_vcZGt6n8xoQz5ggtY1qbfjL3cYFBmvAZLONsBowYUEdtIuhv8s8g5fSJg6</recordid><startdate>19940501</startdate><enddate>19940501</enddate><creator>Penning, Donald H.</creator><creator>Grafe, Marjorie R.</creator><creator>Hammond, Robert</creator><creator>Matsuda, Yoshio</creator><creator>Patrick, John</creator><creator>Richardson, Bryan</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940501</creationdate><title>Neuropathology of the near-term and midgestation ovine fetal brain after sustained in utero hypoxemia</title><author>Penning, Donald H. ; Grafe, Marjorie R. ; Hammond, Robert ; Matsuda, Yoshio ; Patrick, John ; Richardson, Bryan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c321t-10fc26f9213eb4d9fbe104db9873ede807829ad2e26384cb5e5d394443b06cdd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Acidosis - complications</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>Brain Diseases - etiology</topic><topic>Brain Diseases - pathology</topic><topic>Cerebral palsy</topic><topic>development</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Fetal Blood - chemistry</topic><topic>Fetal Diseases - etiology</topic><topic>Fetal Diseases - pathology</topic><topic>Gestational Age</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>hypoxia</topic><topic>Hypoxia - complications</topic><topic>Medical sciences</topic><topic>Necrosis</topic><topic>ovine fetus</topic><topic>periventricular leukomalacia</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Sheep</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Penning, Donald H.</creatorcontrib><creatorcontrib>Grafe, Marjorie R.</creatorcontrib><creatorcontrib>Hammond, Robert</creatorcontrib><creatorcontrib>Matsuda, Yoshio</creatorcontrib><creatorcontrib>Patrick, John</creatorcontrib><creatorcontrib>Richardson, Bryan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Penning, Donald H.</au><au>Grafe, Marjorie R.</au><au>Hammond, Robert</au><au>Matsuda, Yoshio</au><au>Patrick, John</au><au>Richardson, Bryan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuropathology of the near-term and midgestation ovine fetal brain after sustained in utero hypoxemia</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1994-05-01</date><risdate>1994</risdate><volume>170</volume><issue>5</issue><spage>1425</spage><epage>1432</epage><pages>1425-1432</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>OBJECTIVE: The neuropathologic mechanisms of the ovine fetal brain in response to several hours of sustained hypoxemia with variable degrees of metabolic acidemia was investigated in both the preterm and near-term ovine fetus.
STUDY DESIGN: Three groups of fetuses were studied in each of the near-term and midgestation groups: a hypoxic group, a control group, and an uninstrumented control group. Histopathologic studies were performed after a 40-hour recovery period after experimentation.
RESULTS: Pathologic findings consisted of predominately white matter damage with some adjacent cortical necrosis but no selective neuronal injury. In the near-term group the hypoxia group fetuses demonstrated significantly higher white matter injury scores than did control group fetuses (p < 0.05). Periventricular white matter injury was the predominant pattern seen in the midgestation group.
CONCLUSIONS: In spite of normalization of biophysical and biochemical parameters after hypoxemia both midgestation and near-term fetuses sustained pathologic changes. Presence or extent of injury did not correlate with the degree of hypoxemia or metabolic acidosis achieved.</abstract><cop>Philadelphia, PA</cop><pub>Elsevier Inc</pub><pmid>8178885</pmid><doi>10.1016/S0002-9378(13)90484-1</doi><tpages>8</tpages></addata></record> |
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| ispartof | American journal of obstetrics and gynecology, 1994-05, Vol.170 (5), p.1425-1432 |
| issn | 0002-9378 1097-6868 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Acidosis - complications Animals Biological and medical sciences Brain - pathology Brain Diseases - etiology Brain Diseases - pathology Cerebral palsy development Diseases of mother, fetus and pregnancy Female Fetal Blood - chemistry Fetal Diseases - etiology Fetal Diseases - pathology Gestational Age Gynecology. Andrology. Obstetrics hypoxia Hypoxia - complications Medical sciences Necrosis ovine fetus periventricular leukomalacia Pregnancy Pregnancy. Fetus. Placenta Sheep |
| title | Neuropathology of the near-term and midgestation ovine fetal brain after sustained in utero hypoxemia |
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