Serotonergic terminals express a growth associated protein (GAP-43) in the adult rat spinal cord
Dual colour immunofluorescence has been used to compare the distribution of serotonin (5-hydroxytryptamine, 5-HT) and GAP-43 in the adult rat. GAP-43 immunostaining was observed in all spinal cord regions containing 5-HT immunoreactivity. 5-HT and GAP-43 double labelled fibres and varicosities were...
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| Veröffentlicht in: | Neuroscience letters 1994-02, Vol.167 (1), p.67-72 |
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| container_title | Neuroscience letters |
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| creator | Ching, Y.P. Averill, S. Wilkin, G.P. Wotherspoon, G. Priestley, J.V. |
| description | Dual colour immunofluorescence has been used to compare the distribution of serotonin (5-hydroxytryptamine, 5-HT) and GAP-43 in the adult rat. GAP-43 immunostaining was observed in all spinal cord regions containing 5-HT immunoreactivity. 5-HT and GAP-43 double labelled fibres and varicosities were present and were most evident around motoneurones, in lamina X, and in the intermediolateral cell column. Single labelled GAP-43 fibres and varicosities were also observed and were the dominant population in the dorsal horn and in certain fibre tracts. We conclude that the 5-HT system is one of a small number of spinal cord systems that express high levels of GAP-43 in the adult. |
| doi_str_mv | 10.1016/0304-3940(94)91029-4 |
| format | Article |
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GAP-43 immunostaining was observed in all spinal cord regions containing 5-HT immunoreactivity. 5-HT and GAP-43 double labelled fibres and varicosities were present and were most evident around motoneurones, in lamina X, and in the intermediolateral cell column. Single labelled GAP-43 fibres and varicosities were also observed and were the dominant population in the dorsal horn and in certain fibre tracts. We conclude that the 5-HT system is one of a small number of spinal cord systems that express high levels of GAP-43 in the adult.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/0304-3940(94)91029-4</identifier><identifier>PMID: 8177531</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Biochemistry and metabolism ; Biological and medical sciences ; Central nervous system ; Coexistence ; Double labelling ; Fluorescent Antibody Technique ; Fundamental and applied biological sciences. Psychology ; GAP-43 ; GAP-43 Protein ; Growth Substances - metabolism ; Immunofluorescence ; Male ; Membrane Glycoproteins - metabolism ; Motoneurone ; Motor Neurons - metabolism ; Nerve Endings - metabolism ; Nerve Tissue Proteins - metabolism ; Rats ; Rats, Wistar ; Serotonin ; Serotonin - metabolism ; Spinal cord ; Spinal Cord - cytology ; Spinal Cord - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 1994-02, Vol.167 (1), p.67-72</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-322b7b4bf16dc4f39707e7f96ff34ca81017b98db06934bd68047fe6546d50c23</citedby><cites>FETCH-LOGICAL-c417t-322b7b4bf16dc4f39707e7f96ff34ca81017b98db06934bd68047fe6546d50c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0304394094910294$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3925507$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8177531$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ching, Y.P.</creatorcontrib><creatorcontrib>Averill, S.</creatorcontrib><creatorcontrib>Wilkin, G.P.</creatorcontrib><creatorcontrib>Wotherspoon, G.</creatorcontrib><creatorcontrib>Priestley, J.V.</creatorcontrib><title>Serotonergic terminals express a growth associated protein (GAP-43) in the adult rat spinal cord</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Dual colour immunofluorescence has been used to compare the distribution of serotonin (5-hydroxytryptamine, 5-HT) and GAP-43 in the adult rat. GAP-43 immunostaining was observed in all spinal cord regions containing 5-HT immunoreactivity. 5-HT and GAP-43 double labelled fibres and varicosities were present and were most evident around motoneurones, in lamina X, and in the intermediolateral cell column. Single labelled GAP-43 fibres and varicosities were also observed and were the dominant population in the dorsal horn and in certain fibre tracts. We conclude that the 5-HT system is one of a small number of spinal cord systems that express high levels of GAP-43 in the adult.</description><subject>Animals</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Coexistence</subject><subject>Double labelling</subject><subject>Fluorescent Antibody Technique</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GAP-43</subject><subject>GAP-43 Protein</subject><subject>Growth Substances - metabolism</subject><subject>Immunofluorescence</subject><subject>Male</subject><subject>Membrane Glycoproteins - metabolism</subject><subject>Motoneurone</subject><subject>Motor Neurons - metabolism</subject><subject>Nerve Endings - metabolism</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Serotonin</subject><subject>Serotonin - metabolism</subject><subject>Spinal cord</subject><subject>Spinal Cord - cytology</subject><subject>Spinal Cord - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVFrFDEQx4Mo9Vr9Bgp5EGkfVpPNbLJ5EUqpVShUUJ9jNpm0kb3dM8lZ--3Nesc92qcE5jc_Zv5DyCvO3nHG5XsmGDRCAzvVcKY5a3UDT8iK96ptlFbtU7I6IM_Jcc4_GWMd7-CIHPVcqU7wFfnxFdNc5gnTbXS0YFrHyY6Z4p9Nwpyppbdpvi931OY8u2gLerqpHRgnenp1_qUBcUbrv9whtX47FppsoXmzWKibk39BnoUqxJf794R8_3j57eJTc31z9fni_LpxwFVpRNsOaoAhcOkdBKEVU6iCliEIcLavG6tB935gUgsYvOwZqICyA-k75lpxQt7uvHW6X1vMxaxjdjiOdsJ5m42SoLTm8CjIZQ9aal5B2IEuzTknDGaT4tqmB8OZWS5glnjNEq_RYP5dwCz-13v_dlijPzTtI6_1N_u6zc6OIdnJxXzAhG67jqmKfdhhWEP7HTGZ7CJODn1M6Irxc_z_HH8BxomgqA</recordid><startdate>19940214</startdate><enddate>19940214</enddate><creator>Ching, Y.P.</creator><creator>Averill, S.</creator><creator>Wilkin, G.P.</creator><creator>Wotherspoon, G.</creator><creator>Priestley, J.V.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19940214</creationdate><title>Serotonergic terminals express a growth associated protein (GAP-43) in the adult rat spinal cord</title><author>Ching, Y.P. ; Averill, S. ; Wilkin, G.P. ; Wotherspoon, G. ; Priestley, J.V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-322b7b4bf16dc4f39707e7f96ff34ca81017b98db06934bd68047fe6546d50c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Coexistence</topic><topic>Double labelling</topic><topic>Fluorescent Antibody Technique</topic><topic>Fundamental and applied biological sciences. 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GAP-43 immunostaining was observed in all spinal cord regions containing 5-HT immunoreactivity. 5-HT and GAP-43 double labelled fibres and varicosities were present and were most evident around motoneurones, in lamina X, and in the intermediolateral cell column. Single labelled GAP-43 fibres and varicosities were also observed and were the dominant population in the dorsal horn and in certain fibre tracts. We conclude that the 5-HT system is one of a small number of spinal cord systems that express high levels of GAP-43 in the adult.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>8177531</pmid><doi>10.1016/0304-3940(94)91029-4</doi><tpages>6</tpages></addata></record> |
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| ispartof | Neuroscience letters, 1994-02, Vol.167 (1), p.67-72 |
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| language | eng |
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| subjects | Animals Biochemistry and metabolism Biological and medical sciences Central nervous system Coexistence Double labelling Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology GAP-43 GAP-43 Protein Growth Substances - metabolism Immunofluorescence Male Membrane Glycoproteins - metabolism Motoneurone Motor Neurons - metabolism Nerve Endings - metabolism Nerve Tissue Proteins - metabolism Rats Rats, Wistar Serotonin Serotonin - metabolism Spinal cord Spinal Cord - cytology Spinal Cord - metabolism Vertebrates: nervous system and sense organs |
| title | Serotonergic terminals express a growth associated protein (GAP-43) in the adult rat spinal cord |
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