Growth hormone treatment in growth-retarded adolescents after renal transplant

Growth failure is a psychosocial problem for many patients who have undergone renal transplantation. 18 adolescents (mean age 15 6, range 11·3-19 5) with severe growth retardation after renal transplantation were treated with biosynthetic growth hormone (GH) for 2 years. All received prednisone, adm...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The Lancet (British edition) 1994-05, Vol.343 (8909), p.1313-1317
Hauptverfasser: Hokken-Koelega, A.C.S., de Munck Keizer-Schrama, S.M.P.F., Drop, S.L.S., Wolff, E.D., Stijnen, T., de Ridder, M.A.J., de Jong, M.C.J.W., Donckerwolcke, R.A., Groothoff, J.W., Blum, W.F.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1317
container_issue 8909
container_start_page 1313
container_title The Lancet (British edition)
container_volume 343
creator Hokken-Koelega, A.C.S.
de Munck Keizer-Schrama, S.M.P.F.
Drop, S.L.S.
Wolff, E.D.
Stijnen, T.
de Ridder, M.A.J.
de Jong, M.C.J.W.
Donckerwolcke, R.A.
Groothoff, J.W.
Blum, W.F.
description Growth failure is a psychosocial problem for many patients who have undergone renal transplantation. 18 adolescents (mean age 15 6, range 11·3-19 5) with severe growth retardation after renal transplantation were treated with biosynthetic growth hormone (GH) for 2 years. All received prednisone, administered daily or on alternate days, with azathioprine and/or cyclosporin A. 16 were blindly assigned to one of two GH doses (4 vs 8 IU per m 2 per day). Growth, bone maturation, renal graft function, plasma insulin-like growth factors, serum binding proteins, and other biochemical parameters were checked regularly. Glomerular filtration rate and effective renal plasma flow were tested with 125I-Thalamate and 131I-Hippuran. Data on growth and glomerular filtration rate during GH treatment were also compared with those of matched non-GH-treated controls. Mean (standard deviation) increment in height after 2 years of GH was 15·7 (5·1) cm, significantly greater (p25% reduction in glomerular filtration rate over 2 years was not significantly higher in GH-treated patients than in non-GH-treated controls (39% vs 32%, p=0·97). Although a few patients had deterioration of graft function, we could not find a relation with GH treatment. Our results show that sustained improvement of height can be achieved with GH in severely growth-retarded adolescents after renal transplantation.
doi_str_mv 10.1016/S0140-6736(94)92465-1
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76479489</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0140673694924651</els_id><sourcerecordid>76479489</sourcerecordid><originalsourceid>FETCH-LOGICAL-c529t-cf1f27ca4b1ee247498ba104b95f02370cdd60c8d32ae3c0a73ae01d5266dafa3</originalsourceid><addsrcrecordid>eNqFkE1rFTEUhkNR6m3tTygMRaRdjJ5kMslkJVL6IRRdqOAunJucsVNmJrdJruK_N_eDu3Dj6ize5z28PIydc3jHgav3X4FLqJVu1KWRV0ZI1db8iC241LJupf7xgi0OyCt2ktITAEgF7TE71oZDI8SCfb6L4Xd-rB5DnMJMVY6EeaI5V8Nc_dxmdaSM0ZOv0IeRkitpqrDPFKtIM46lhHNajTjn1-xlj2Ois_09Zd9vb75d39cPX-4-XX98qF0rTK5dz3uhHcolJxJlsOmWyEEuTduDaDQ47xW4zjcCqXGAukEC7luhlMcem1P2dvd3FcPzmlK201CGjWUDhXWyWkltZGcKePEP-BTWsYxOlpvOtNo0ukDtDnIxpBSpt6s4TBj_WA52I9tuZduNSWuk3cq2vPTO98_Xy4n8obW3W_I3-xyTw7EvmtyQDpiEjguzwT7sMCrGfg0UbXIDzY78EMll68PwnyF_AdmcnBw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>198957937</pqid></control><display><type>article</type><title>Growth hormone treatment in growth-retarded adolescents after renal transplant</title><source>MEDLINE</source><source>EBSCOhost Business Source Complete</source><source>Access via ScienceDirect (Elsevier)</source><source>ProQuest Central UK/Ireland</source><creator>Hokken-Koelega, A.C.S. ; de Munck Keizer-Schrama, S.M.P.F. ; Drop, S.L.S. ; Wolff, E.D. ; Stijnen, T. ; de Ridder, M.A.J. ; de Jong, M.C.J.W. ; Donckerwolcke, R.A. ; Groothoff, J.W. ; Blum, W.F.</creator><creatorcontrib>Hokken-Koelega, A.C.S. ; de Munck Keizer-Schrama, S.M.P.F. ; Drop, S.L.S. ; Wolff, E.D. ; Stijnen, T. ; de Ridder, M.A.J. ; de Jong, M.C.J.W. ; Donckerwolcke, R.A. ; Groothoff, J.W. ; Blum, W.F.</creatorcontrib><description>Growth failure is a psychosocial problem for many patients who have undergone renal transplantation. 18 adolescents (mean age 15 6, range 11·3-19 5) with severe growth retardation after renal transplantation were treated with biosynthetic growth hormone (GH) for 2 years. All received prednisone, administered daily or on alternate days, with azathioprine and/or cyclosporin A. 16 were blindly assigned to one of two GH doses (4 vs 8 IU per m 2 per day). Growth, bone maturation, renal graft function, plasma insulin-like growth factors, serum binding proteins, and other biochemical parameters were checked regularly. Glomerular filtration rate and effective renal plasma flow were tested with 125I-Thalamate and 131I-Hippuran. Data on growth and glomerular filtration rate during GH treatment were also compared with those of matched non-GH-treated controls. Mean (standard deviation) increment in height after 2 years of GH was 15·7 (5·1) cm, significantly greater (p&lt;0 0001) than in matched controls, 5 8 (3 4) cm. Results were similar for the two GH dosage groups. Bone maturation was not accelerated. Glomerular filtration rate and effective renal plasma flow did not change significantly. The incidence of a &gt;25% reduction in glomerular filtration rate over 2 years was not significantly higher in GH-treated patients than in non-GH-treated controls (39% vs 32%, p=0·97). Although a few patients had deterioration of graft function, we could not find a relation with GH treatment. Our results show that sustained improvement of height can be achieved with GH in severely growth-retarded adolescents after renal transplantation.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(94)92465-1</identifier><identifier>PMID: 7910322</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Adolescent ; Adolescents ; Adult ; Biological and medical sciences ; Child ; Dose-Response Relationship, Drug ; Double-Blind Method ; Drugs ; Female ; Glomerular Filtration Rate ; Growth Disorders - drug therapy ; Growth Disorders - etiology ; Growth Disorders - physiopathology ; Growth factors ; Growth Hormone - therapeutic use ; Hormones ; Hormones. Endocrine system ; Humans ; Kidney transplantation ; Kidney Transplantation - adverse effects ; Male ; Medical research ; Medical sciences ; Pharmacology. Drug treatments ; Physical growth ; Teenagers ; Transplantation</subject><ispartof>The Lancet (British edition), 1994-05, Vol.343 (8909), p.1313-1317</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><rights>Copyright Lancet Ltd. May 28, 1994</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-cf1f27ca4b1ee247498ba104b95f02370cdd60c8d32ae3c0a73ae01d5266dafa3</citedby><cites>FETCH-LOGICAL-c529t-cf1f27ca4b1ee247498ba104b95f02370cdd60c8d32ae3c0a73ae01d5266dafa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/198957937?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999,64389,64391,64393,72473</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=4081292$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7910322$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hokken-Koelega, A.C.S.</creatorcontrib><creatorcontrib>de Munck Keizer-Schrama, S.M.P.F.</creatorcontrib><creatorcontrib>Drop, S.L.S.</creatorcontrib><creatorcontrib>Wolff, E.D.</creatorcontrib><creatorcontrib>Stijnen, T.</creatorcontrib><creatorcontrib>de Ridder, M.A.J.</creatorcontrib><creatorcontrib>de Jong, M.C.J.W.</creatorcontrib><creatorcontrib>Donckerwolcke, R.A.</creatorcontrib><creatorcontrib>Groothoff, J.W.</creatorcontrib><creatorcontrib>Blum, W.F.</creatorcontrib><title>Growth hormone treatment in growth-retarded adolescents after renal transplant</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>Growth failure is a psychosocial problem for many patients who have undergone renal transplantation. 18 adolescents (mean age 15 6, range 11·3-19 5) with severe growth retardation after renal transplantation were treated with biosynthetic growth hormone (GH) for 2 years. All received prednisone, administered daily or on alternate days, with azathioprine and/or cyclosporin A. 16 were blindly assigned to one of two GH doses (4 vs 8 IU per m 2 per day). Growth, bone maturation, renal graft function, plasma insulin-like growth factors, serum binding proteins, and other biochemical parameters were checked regularly. Glomerular filtration rate and effective renal plasma flow were tested with 125I-Thalamate and 131I-Hippuran. Data on growth and glomerular filtration rate during GH treatment were also compared with those of matched non-GH-treated controls. Mean (standard deviation) increment in height after 2 years of GH was 15·7 (5·1) cm, significantly greater (p&lt;0 0001) than in matched controls, 5 8 (3 4) cm. Results were similar for the two GH dosage groups. Bone maturation was not accelerated. Glomerular filtration rate and effective renal plasma flow did not change significantly. The incidence of a &gt;25% reduction in glomerular filtration rate over 2 years was not significantly higher in GH-treated patients than in non-GH-treated controls (39% vs 32%, p=0·97). Although a few patients had deterioration of graft function, we could not find a relation with GH treatment. Our results show that sustained improvement of height can be achieved with GH in severely growth-retarded adolescents after renal transplantation.</description><subject>Adolescent</subject><subject>Adolescents</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Drugs</subject><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>Growth Disorders - drug therapy</subject><subject>Growth Disorders - etiology</subject><subject>Growth Disorders - physiopathology</subject><subject>Growth factors</subject><subject>Growth Hormone - therapeutic use</subject><subject>Hormones</subject><subject>Hormones. Endocrine system</subject><subject>Humans</subject><subject>Kidney transplantation</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Physical growth</subject><subject>Teenagers</subject><subject>Transplantation</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkE1rFTEUhkNR6m3tTygMRaRdjJ5kMslkJVL6IRRdqOAunJucsVNmJrdJruK_N_eDu3Dj6ize5z28PIydc3jHgav3X4FLqJVu1KWRV0ZI1db8iC241LJupf7xgi0OyCt2ktITAEgF7TE71oZDI8SCfb6L4Xd-rB5DnMJMVY6EeaI5V8Nc_dxmdaSM0ZOv0IeRkitpqrDPFKtIM46lhHNajTjn1-xlj2Ois_09Zd9vb75d39cPX-4-XX98qF0rTK5dz3uhHcolJxJlsOmWyEEuTduDaDQ47xW4zjcCqXGAukEC7luhlMcem1P2dvd3FcPzmlK201CGjWUDhXWyWkltZGcKePEP-BTWsYxOlpvOtNo0ukDtDnIxpBSpt6s4TBj_WA52I9tuZduNSWuk3cq2vPTO98_Xy4n8obW3W_I3-xyTw7EvmtyQDpiEjguzwT7sMCrGfg0UbXIDzY78EMll68PwnyF_AdmcnBw</recordid><startdate>19940528</startdate><enddate>19940528</enddate><creator>Hokken-Koelega, A.C.S.</creator><creator>de Munck Keizer-Schrama, S.M.P.F.</creator><creator>Drop, S.L.S.</creator><creator>Wolff, E.D.</creator><creator>Stijnen, T.</creator><creator>de Ridder, M.A.J.</creator><creator>de Jong, M.C.J.W.</creator><creator>Donckerwolcke, R.A.</creator><creator>Groothoff, J.W.</creator><creator>Blum, W.F.</creator><general>Elsevier Ltd</general><general>Lancet</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TT</scope><scope>0TZ</scope><scope>0U~</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88C</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8C2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>KB~</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>19940528</creationdate><title>Growth hormone treatment in growth-retarded adolescents after renal transplant</title><author>Hokken-Koelega, A.C.S. ; de Munck Keizer-Schrama, S.M.P.F. ; Drop, S.L.S. ; Wolff, E.D. ; Stijnen, T. ; de Ridder, M.A.J. ; de Jong, M.C.J.W. ; Donckerwolcke, R.A. ; Groothoff, J.W. ; Blum, W.F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-cf1f27ca4b1ee247498ba104b95f02370cdd60c8d32ae3c0a73ae01d5266dafa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adolescent</topic><topic>Adolescents</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>Drugs</topic><topic>Female</topic><topic>Glomerular Filtration Rate</topic><topic>Growth Disorders - drug therapy</topic><topic>Growth Disorders - etiology</topic><topic>Growth Disorders - physiopathology</topic><topic>Growth factors</topic><topic>Growth Hormone - therapeutic use</topic><topic>Hormones</topic><topic>Hormones. Endocrine system</topic><topic>Humans</topic><topic>Kidney transplantation</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Physical growth</topic><topic>Teenagers</topic><topic>Transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hokken-Koelega, A.C.S.</creatorcontrib><creatorcontrib>de Munck Keizer-Schrama, S.M.P.F.</creatorcontrib><creatorcontrib>Drop, S.L.S.</creatorcontrib><creatorcontrib>Wolff, E.D.</creatorcontrib><creatorcontrib>Stijnen, T.</creatorcontrib><creatorcontrib>de Ridder, M.A.J.</creatorcontrib><creatorcontrib>de Jong, M.C.J.W.</creatorcontrib><creatorcontrib>Donckerwolcke, R.A.</creatorcontrib><creatorcontrib>Groothoff, J.W.</creatorcontrib><creatorcontrib>Blum, W.F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>News PRO</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Global News &amp; ABI/Inform Professional</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Lancet Titles</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>ProQuest Newsstand Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hokken-Koelega, A.C.S.</au><au>de Munck Keizer-Schrama, S.M.P.F.</au><au>Drop, S.L.S.</au><au>Wolff, E.D.</au><au>Stijnen, T.</au><au>de Ridder, M.A.J.</au><au>de Jong, M.C.J.W.</au><au>Donckerwolcke, R.A.</au><au>Groothoff, J.W.</au><au>Blum, W.F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Growth hormone treatment in growth-retarded adolescents after renal transplant</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>1994-05-28</date><risdate>1994</risdate><volume>343</volume><issue>8909</issue><spage>1313</spage><epage>1317</epage><pages>1313-1317</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>Growth failure is a psychosocial problem for many patients who have undergone renal transplantation. 18 adolescents (mean age 15 6, range 11·3-19 5) with severe growth retardation after renal transplantation were treated with biosynthetic growth hormone (GH) for 2 years. All received prednisone, administered daily or on alternate days, with azathioprine and/or cyclosporin A. 16 were blindly assigned to one of two GH doses (4 vs 8 IU per m 2 per day). Growth, bone maturation, renal graft function, plasma insulin-like growth factors, serum binding proteins, and other biochemical parameters were checked regularly. Glomerular filtration rate and effective renal plasma flow were tested with 125I-Thalamate and 131I-Hippuran. Data on growth and glomerular filtration rate during GH treatment were also compared with those of matched non-GH-treated controls. Mean (standard deviation) increment in height after 2 years of GH was 15·7 (5·1) cm, significantly greater (p&lt;0 0001) than in matched controls, 5 8 (3 4) cm. Results were similar for the two GH dosage groups. Bone maturation was not accelerated. Glomerular filtration rate and effective renal plasma flow did not change significantly. The incidence of a &gt;25% reduction in glomerular filtration rate over 2 years was not significantly higher in GH-treated patients than in non-GH-treated controls (39% vs 32%, p=0·97). Although a few patients had deterioration of graft function, we could not find a relation with GH treatment. Our results show that sustained improvement of height can be achieved with GH in severely growth-retarded adolescents after renal transplantation.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>7910322</pmid><doi>10.1016/S0140-6736(94)92465-1</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0140-6736
ispartof The Lancet (British edition), 1994-05, Vol.343 (8909), p.1313-1317
issn 0140-6736
1474-547X
language eng
recordid cdi_proquest_miscellaneous_76479489
source MEDLINE; EBSCOhost Business Source Complete; Access via ScienceDirect (Elsevier); ProQuest Central UK/Ireland
subjects Adolescent
Adolescents
Adult
Biological and medical sciences
Child
Dose-Response Relationship, Drug
Double-Blind Method
Drugs
Female
Glomerular Filtration Rate
Growth Disorders - drug therapy
Growth Disorders - etiology
Growth Disorders - physiopathology
Growth factors
Growth Hormone - therapeutic use
Hormones
Hormones. Endocrine system
Humans
Kidney transplantation
Kidney Transplantation - adverse effects
Male
Medical research
Medical sciences
Pharmacology. Drug treatments
Physical growth
Teenagers
Transplantation
title Growth hormone treatment in growth-retarded adolescents after renal transplant
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T20%3A42%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Growth%20hormone%20treatment%20in%20growth-retarded%20adolescents%20after%20renal%20transplant&rft.jtitle=The%20Lancet%20(British%20edition)&rft.au=Hokken-Koelega,%20A.C.S.&rft.date=1994-05-28&rft.volume=343&rft.issue=8909&rft.spage=1313&rft.epage=1317&rft.pages=1313-1317&rft.issn=0140-6736&rft.eissn=1474-547X&rft.coden=LANCAO&rft_id=info:doi/10.1016/S0140-6736(94)92465-1&rft_dat=%3Cproquest_cross%3E76479489%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=198957937&rft_id=info:pmid/7910322&rft_els_id=S0140673694924651&rfr_iscdi=true