In-vitro activity of BMY 28142, a new aminothiazolyl cephalosporin
The in-vitro activity of BMY 28142, a new α-methoxyimino aminothiazolyl cephalosporin, was determined by microdilution broth techniques. The agent demonstrated excellent activity against recent clinical Enterobacteriaceae isolates with a 90% minimum inhibitory concentration (MIC90) of 0·25 mg/l or l...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 1985-10, Vol.16 (4), p.463-468 |
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| container_end_page | 468 |
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| container_issue | 4 |
| container_start_page | 463 |
| container_title | Journal of antimicrobial chemotherapy |
| container_volume | 16 |
| creator | Steele, John C. H. Edwards, Barbara H. Rissing, J. Peter |
| description | The in-vitro activity of BMY 28142, a new α-methoxyimino aminothiazolyl cephalosporin, was determined by microdilution broth techniques. The agent demonstrated excellent activity against recent clinical Enterobacteriaceae isolates with a 90% minimum inhibitory concentration (MIC90) of 0·25 mg/l or less for all but one species tested. BMY 28142 inhibited all Pseudomonas aeruginosa strains tested (MIC90=8·0 mg/l) as well as most other non-fermentative bacteria studied. Methicillin-susceptible Staphylococcus aureus were susceptible to BMY 28142 with MIC90=4·0 mg/l, while methicillin-resistant strains were generally resistant (MIC range 8–>32 mg/l). |
| doi_str_mv | 10.1093/jac/16.4.463 |
| format | Article |
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Methicillin-susceptible Staphylococcus aureus were susceptible to BMY 28142 with MIC90=4·0 mg/l, while methicillin-resistant strains were generally resistant (MIC range 8–>32 mg/l).</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/16.4.463</identifier><identifier>PMID: 3840799</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Acinetobacter - drug effects ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Bacteria - drug effects ; Biological and medical sciences ; Cefepime ; Cephalosporins - pharmacology ; Enterobacteriaceae ; Enterobacteriaceae - drug effects ; Medical sciences ; Methicillin - pharmacology ; Microbial Sensitivity Tests ; Pharmacology. 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H.</creatorcontrib><creatorcontrib>Edwards, Barbara H.</creatorcontrib><creatorcontrib>Rissing, J. Peter</creatorcontrib><title>In-vitro activity of BMY 28142, a new aminothiazolyl cephalosporin</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J Antimicrob Chemother</addtitle><description>The in-vitro activity of BMY 28142, a new α-methoxyimino aminothiazolyl cephalosporin, was determined by microdilution broth techniques. The agent demonstrated excellent activity against recent clinical Enterobacteriaceae isolates with a 90% minimum inhibitory concentration (MIC90) of 0·25 mg/l or less for all but one species tested. BMY 28142 inhibited all Pseudomonas aeruginosa strains tested (MIC90=8·0 mg/l) as well as most other non-fermentative bacteria studied. Methicillin-susceptible Staphylococcus aureus were susceptible to BMY 28142 with MIC90=4·0 mg/l, while methicillin-resistant strains were generally resistant (MIC range 8–>32 mg/l).</description><subject>Acinetobacter - drug effects</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacteria - drug effects</subject><subject>Biological and medical sciences</subject><subject>Cefepime</subject><subject>Cephalosporins - pharmacology</subject><subject>Enterobacteriaceae</subject><subject>Enterobacteriaceae - drug effects</subject><subject>Medical sciences</subject><subject>Methicillin - pharmacology</subject><subject>Microbial Sensitivity Tests</subject><subject>Pharmacology. Drug treatments</subject><subject>Pseudomonas aeruginosa</subject><subject>Staphylococcus aureus - drug effects</subject><issn>0305-7453</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1rGzEQBmBRElLH6a3Xwh5KT1lH2tHnsTZNHHAIhBSaXIQ8qyVK1ytHWrdxfn232Pia0wy8D8PwEvKZ0QmjBi6eHV4wOeETLuEDGTEuaVlRw47IiAIVpeICPpLTnJ8ppVJIfUJOQHOqjBmR6XVX_gl9ioXDPgzbtohNMb15KCrNeHVeuKLzfwu3Cl3sn4J7i-22LdCvn1wb8zqm0J2R48a12X_azzH5efnjfjYvF7dX17PvixIrY_qSU9EA1d7VArWXWEmstULBhATOOQisOVRKMPSNWKIBbITTHGu15ExDDWPybXd3neLLxuferkJG37au83GTrZJcaUOrdyHjwy-g9QDPdxBTzDn5xq5TWLm0tYza_93aoVvLpOV26HbgX_Z3N8uVrw94X-aQf93nLqNrm-Q6DPnAtGAgDR1YuWMh9_71ELv020oFStj5r0c7lXcg6P3cGvgH9ZGObw</recordid><startdate>198510</startdate><enddate>198510</enddate><creator>Steele, John C. H.</creator><creator>Edwards, Barbara H.</creator><creator>Rissing, J. 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Antiparasitic agents</topic><topic>Bacteria - drug effects</topic><topic>Biological and medical sciences</topic><topic>Cefepime</topic><topic>Cephalosporins - pharmacology</topic><topic>Enterobacteriaceae</topic><topic>Enterobacteriaceae - drug effects</topic><topic>Medical sciences</topic><topic>Methicillin - pharmacology</topic><topic>Microbial Sensitivity Tests</topic><topic>Pharmacology. Drug treatments</topic><topic>Pseudomonas aeruginosa</topic><topic>Staphylococcus aureus - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Steele, John C. H.</creatorcontrib><creatorcontrib>Edwards, Barbara H.</creatorcontrib><creatorcontrib>Rissing, J. 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H.</au><au>Edwards, Barbara H.</au><au>Rissing, J. Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In-vitro activity of BMY 28142, a new aminothiazolyl cephalosporin</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J Antimicrob Chemother</addtitle><date>1985-10</date><risdate>1985</risdate><volume>16</volume><issue>4</issue><spage>463</spage><epage>468</epage><pages>463-468</pages><issn>0305-7453</issn><eissn>1460-2091</eissn><coden>JACHDX</coden><abstract>The in-vitro activity of BMY 28142, a new α-methoxyimino aminothiazolyl cephalosporin, was determined by microdilution broth techniques. The agent demonstrated excellent activity against recent clinical Enterobacteriaceae isolates with a 90% minimum inhibitory concentration (MIC90) of 0·25 mg/l or less for all but one species tested. BMY 28142 inhibited all Pseudomonas aeruginosa strains tested (MIC90=8·0 mg/l) as well as most other non-fermentative bacteria studied. Methicillin-susceptible Staphylococcus aureus were susceptible to BMY 28142 with MIC90=4·0 mg/l, while methicillin-resistant strains were generally resistant (MIC range 8–>32 mg/l).</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>3840799</pmid><doi>10.1093/jac/16.4.463</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0305-7453 |
| ispartof | Journal of antimicrobial chemotherapy, 1985-10, Vol.16 (4), p.463-468 |
| issn | 0305-7453 1460-2091 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Acinetobacter - drug effects Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteria - drug effects Biological and medical sciences Cefepime Cephalosporins - pharmacology Enterobacteriaceae Enterobacteriaceae - drug effects Medical sciences Methicillin - pharmacology Microbial Sensitivity Tests Pharmacology. Drug treatments Pseudomonas aeruginosa Staphylococcus aureus - drug effects |
| title | In-vitro activity of BMY 28142, a new aminothiazolyl cephalosporin |
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