Genetic control of early neuronal development in vertebrates

The specification of neuronal fate starts with cell commitment and determination. These early events are accompanied by rearrangement and reshaping of presumptive neural cells. Later, the neural differentiation begins, and its course can be followed using specific molecular markers. Such events take...

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Veröffentlicht in:Current opinion in neurobiology 1994, Vol.4 (1), p.21-28
1. Verfasser: Korzh, Vladimir P.
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description The specification of neuronal fate starts with cell commitment and determination. These early events are accompanied by rearrangement and reshaping of presumptive neural cells. Later, the neural differentiation begins, and its course can be followed using specific molecular markers. Such events take place long before the cells acquire a typical neuronal phenotype. Primary neurons of lower vertebrates differ from secondary neurons by their size, position, timing of differentiation and length of axon. Primary neurons start to express early markers of neural differentiation at the end of gastrulation. Recent data indicate that in lower vertebrates the neural induction of primary neurons differs from the induction of secondary neurons; however, neural induction in higher vertebrates appears to be similar to the induction of secondary neurons in lower vertebrates.
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subjects Animals
Cell Differentiation
Mutation
Nervous System - embryology
Neurons - cytology
Neurons - physiology
Signal Transduction
Vertebrata
Vertebrates - embryology
Vertebrates - genetics
title Genetic control of early neuronal development in vertebrates
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