Heterodimerization of the IL-2 receptor β- and γ-chain cytoplasmic domains is required for signalling

THE interaction of interleukin-2 (IL-2) and IL-2 receptors criti-cally regulates the T-cell immune response following antigen activation 1,2 . IL-2 can signal through high or intermediate affinity receptors which contain IL-2Rα (refs 3, 4) + β (refs5–8) + γ (ref. 9) or β + γ chains, respectively. IL...

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Veröffentlicht in:	Nature (London) 1994-05, Vol.369 (6478), p.330-333
Hauptverfasser:	Nakamura, Yoshlaki, Russell, Sarah M, Mess, Sarah A, Friedmann, Michael, Erdos, Michael, Francois, Christine, Jacques, Yannick, Adelstein, Stephen, Leonard, Warren J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Bispecific Antibodies, Monoclonal Biological and medical sciences Biopolymers Cell Division - immunology Cell Line Cell receptors Cell structures and functions Cellular biology Cytoplasm - immunology Fundamental and applied biological sciences. Psychology Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors Humanities and Social Sciences Humans letter Medical research Mice Molecular and cellular biology multidisciplinary Mutation Receptors, Interleukin-2 - chemistry Receptors, Interleukin-2 - physiology Recombinant Fusion Proteins Science Science (multidisciplinary) Signal Transduction - immunology Structure-Activity Relationship
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