High-affinity cytotoxic T lymphocytes after non-HLA-sharing blood transfusion : the other side of the coin
Previously, we have shown that pretransplantation blood transfusion modulates the T cell repertoire to a great extent. Patients receiving a BT from a donor sharing one HLA haplotype with the patient (HLA-sharing BT) develop CTL nonresponsiveness against cells of the BT donor and show a selective dec...
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| Veröffentlicht in: | Transplantation 1994-04, Vol.57 (8), p.1246-1251 |
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| container_title | Transplantation |
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| creator | VAN TWUYVER, E MOOIJAART, R. J. D TEN BERGE, I. J. M VAN DER HORST, A. R WILMINK, J. M CLAAS, F. H. J DE WAAL, L. P |
| description | Previously, we have shown that pretransplantation blood transfusion modulates the T cell repertoire to a great extent. Patients receiving a BT from a donor sharing one HLA haplotype with the patient (HLA-sharing BT) develop CTL nonresponsiveness against cells of the BT donor and show a selective decrease in the usage of T cell receptor V beta families. The present study has focused on the analysis of the T cell repertoire in patients receiving an HLA mismatched (non-HLA-sharing) BT. CTL precursor frequencies were measured against single class I-mismatched antigens in split-well analysis. In addition, blocking studies of CTL-target cell interaction were performed with anti-CD8 monoclonal antibodies. The results demonstrate that non-HLA-sharing BT immunizes and induces the generation of CD8 independent, high-affinity CTL against immunogenic class I-mismatched antigens. Such HLA class I antigens might become nonacceptable mismatches in subsequent organ transplantation. |
| doi_str_mv | 10.1097/00007890-199404270-00018 |
| format | Article |
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J. D ; TEN BERGE, I. J. M ; VAN DER HORST, A. R ; WILMINK, J. M ; CLAAS, F. H. J ; DE WAAL, L. P</creator><creatorcontrib>VAN TWUYVER, E ; MOOIJAART, R. J. D ; TEN BERGE, I. J. M ; VAN DER HORST, A. R ; WILMINK, J. M ; CLAAS, F. H. J ; DE WAAL, L. P</creatorcontrib><description>Previously, we have shown that pretransplantation blood transfusion modulates the T cell repertoire to a great extent. Patients receiving a BT from a donor sharing one HLA haplotype with the patient (HLA-sharing BT) develop CTL nonresponsiveness against cells of the BT donor and show a selective decrease in the usage of T cell receptor V beta families. The present study has focused on the analysis of the T cell repertoire in patients receiving an HLA mismatched (non-HLA-sharing) BT. CTL precursor frequencies were measured against single class I-mismatched antigens in split-well analysis. In addition, blocking studies of CTL-target cell interaction were performed with anti-CD8 monoclonal antibodies. The results demonstrate that non-HLA-sharing BT immunizes and induces the generation of CD8 independent, high-affinity CTL against immunogenic class I-mismatched antigens. Such HLA class I antigens might become nonacceptable mismatches in subsequent organ transplantation.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/00007890-199404270-00018</identifier><identifier>PMID: 8178352</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Alleles ; Antibodies, Monoclonal - immunology ; Biological and medical sciences ; Blood Group Incompatibility - etiology ; CD8 Antigens - immunology ; Down-Regulation ; HLA Antigens - analysis ; HLA Antigens - genetics ; Humans ; Kidney Transplantation - immunology ; Medical sciences ; Receptors, Antigen, T-Cell, alpha-beta - immunology ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the urinary system ; T-Lymphocytes, Cytotoxic - cytology ; T-Lymphocytes, Cytotoxic - physiology ; Transfusion Reaction</subject><ispartof>Transplantation, 1994-04, Vol.57 (8), p.1246-1251</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-fe7c2c0bc42799ef465e0184f8e8945399fb3705f550fc5e8e825333b41cb2613</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4099897$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8178352$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VAN TWUYVER, E</creatorcontrib><creatorcontrib>MOOIJAART, R. J. D</creatorcontrib><creatorcontrib>TEN BERGE, I. J. M</creatorcontrib><creatorcontrib>VAN DER HORST, A. R</creatorcontrib><creatorcontrib>WILMINK, J. M</creatorcontrib><creatorcontrib>CLAAS, F. H. J</creatorcontrib><creatorcontrib>DE WAAL, L. P</creatorcontrib><title>High-affinity cytotoxic T lymphocytes after non-HLA-sharing blood transfusion : the other side of the coin</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>Previously, we have shown that pretransplantation blood transfusion modulates the T cell repertoire to a great extent. Patients receiving a BT from a donor sharing one HLA haplotype with the patient (HLA-sharing BT) develop CTL nonresponsiveness against cells of the BT donor and show a selective decrease in the usage of T cell receptor V beta families. The present study has focused on the analysis of the T cell repertoire in patients receiving an HLA mismatched (non-HLA-sharing) BT. CTL precursor frequencies were measured against single class I-mismatched antigens in split-well analysis. In addition, blocking studies of CTL-target cell interaction were performed with anti-CD8 monoclonal antibodies. The results demonstrate that non-HLA-sharing BT immunizes and induces the generation of CD8 independent, high-affinity CTL against immunogenic class I-mismatched antigens. Such HLA class I antigens might become nonacceptable mismatches in subsequent organ transplantation.</description><subject>Alleles</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Biological and medical sciences</subject><subject>Blood Group Incompatibility - etiology</subject><subject>CD8 Antigens - immunology</subject><subject>Down-Regulation</subject><subject>HLA Antigens - analysis</subject><subject>HLA Antigens - genetics</subject><subject>Humans</subject><subject>Kidney Transplantation - immunology</subject><subject>Medical sciences</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - immunology</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the urinary system</subject><subject>T-Lymphocytes, Cytotoxic - cytology</subject><subject>T-Lymphocytes, Cytotoxic - physiology</subject><subject>Transfusion Reaction</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1PAyEQhonR1Fr9CSYcjDcUFljAW9OoNWnipZ43LIWWZrtU2Cbuv5d-2KscYHjnnSHMAwAk-IlgJZ5xXkIqjIhSDLNCYJQVIi_AkHDKUIklvgRDjBlBhFJxDW5SWmcLp0IMwEASISkvhmA99csV0s751nc9NH0XuvDjDZzDpt9sVyErNkHtOhthG1o0nY1RWuno2yWsmxAWsIu6TW6XfGjhC-xWFoa8RZj8IofuoJjg21tw5XST7N3pHIGvt9f5ZIpmn-8fk_EMGVbgDjkrTGFwnW9CKetYyW3-GXPSSsU4VcrVVGDuOMfOcJvlglNKa0ZMXZSEjsDjse82hu-dTV218cnYptGtDbtUiZKJkuap_GckpVAFFfuO8mg0MaQUrau20W907CuCqz2P6o9HdeZRHXjk0vvTG7t6YxfnwhOAnH845XUyunF5lsans41hpaQS9BfeKJIu</recordid><startdate>19940427</startdate><enddate>19940427</enddate><creator>VAN TWUYVER, E</creator><creator>MOOIJAART, R. J. D</creator><creator>TEN BERGE, I. J. M</creator><creator>VAN DER HORST, A. R</creator><creator>WILMINK, J. M</creator><creator>CLAAS, F. H. J</creator><creator>DE WAAL, L. P</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19940427</creationdate><title>High-affinity cytotoxic T lymphocytes after non-HLA-sharing blood transfusion : the other side of the coin</title><author>VAN TWUYVER, E ; MOOIJAART, R. J. D ; TEN BERGE, I. J. M ; VAN DER HORST, A. R ; WILMINK, J. M ; CLAAS, F. H. J ; DE WAAL, L. 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Graft diseases</topic><topic>Surgery of the urinary system</topic><topic>T-Lymphocytes, Cytotoxic - cytology</topic><topic>T-Lymphocytes, Cytotoxic - physiology</topic><topic>Transfusion Reaction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VAN TWUYVER, E</creatorcontrib><creatorcontrib>MOOIJAART, R. J. D</creatorcontrib><creatorcontrib>TEN BERGE, I. J. M</creatorcontrib><creatorcontrib>VAN DER HORST, A. R</creatorcontrib><creatorcontrib>WILMINK, J. M</creatorcontrib><creatorcontrib>CLAAS, F. H. J</creatorcontrib><creatorcontrib>DE WAAL, L. 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P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-affinity cytotoxic T lymphocytes after non-HLA-sharing blood transfusion : the other side of the coin</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>1994-04-27</date><risdate>1994</risdate><volume>57</volume><issue>8</issue><spage>1246</spage><epage>1251</epage><pages>1246-1251</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>Previously, we have shown that pretransplantation blood transfusion modulates the T cell repertoire to a great extent. Patients receiving a BT from a donor sharing one HLA haplotype with the patient (HLA-sharing BT) develop CTL nonresponsiveness against cells of the BT donor and show a selective decrease in the usage of T cell receptor V beta families. The present study has focused on the analysis of the T cell repertoire in patients receiving an HLA mismatched (non-HLA-sharing) BT. CTL precursor frequencies were measured against single class I-mismatched antigens in split-well analysis. In addition, blocking studies of CTL-target cell interaction were performed with anti-CD8 monoclonal antibodies. The results demonstrate that non-HLA-sharing BT immunizes and induces the generation of CD8 independent, high-affinity CTL against immunogenic class I-mismatched antigens. Such HLA class I antigens might become nonacceptable mismatches in subsequent organ transplantation.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>8178352</pmid><doi>10.1097/00007890-199404270-00018</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0041-1337 |
| ispartof | Transplantation, 1994-04, Vol.57 (8), p.1246-1251 |
| issn | 0041-1337 1534-6080 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Alleles Antibodies, Monoclonal - immunology Biological and medical sciences Blood Group Incompatibility - etiology CD8 Antigens - immunology Down-Regulation HLA Antigens - analysis HLA Antigens - genetics Humans Kidney Transplantation - immunology Medical sciences Receptors, Antigen, T-Cell, alpha-beta - immunology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system T-Lymphocytes, Cytotoxic - cytology T-Lymphocytes, Cytotoxic - physiology Transfusion Reaction |
| title | High-affinity cytotoxic T lymphocytes after non-HLA-sharing blood transfusion : the other side of the coin |
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