Ceruletide inhibits water intake in deprived mice: Comparison with morphine and the enkephalin analogue, FK 33-824
Subcutaneous injections of ceruletide (caerulein diethylammonium hydrate, CER) reduced dose-dependently the water intake in male NMRI mice deprived of water for 18 h. The ED 50 for this effect was 5.5 (3.70–7.94) nmol/kg, which is 3.7 times more than the corresponding food intake inhibiting dose. Al...
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| Veröffentlicht in: | European journal of pharmacology 1985-08, Vol.114 (3), p.247-251 |
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| creator | Zetler, Gerhard Raberg, Angela |
| description | Subcutaneous injections of ceruletide (caerulein diethylammonium hydrate, CER) reduced dose-dependently the water intake in male NMRI mice deprived of water for 18 h. The ED
50 for this effect was 5.5 (3.70–7.94) nmol/kg, which is 3.7 times more than the corresponding food intake inhibiting dose. Also inhibitory but much less potent than CER were (in decreasing order) FK 33–824, morphine and naloxone. Naloxone was an antagonist to both FK 33–824 and morphine but not to CER, thereby separating CER from the opioids. When water intake reducing doses of CER (15 nmol/kg) and FK 33–824 (850 nmol/kg) were combined, the two peptides were not additive but antagonized each other. Together, the present and previous results suggest that pharmacological inhibition of food and water intake have different characteristics. |
| doi_str_mv | 10.1016/0014-2999(85)90366-8 |
| format | Article |
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50 for this effect was 5.5 (3.70–7.94) nmol/kg, which is 3.7 times more than the corresponding food intake inhibiting dose. Also inhibitory but much less potent than CER were (in decreasing order) FK 33–824, morphine and naloxone. Naloxone was an antagonist to both FK 33–824 and morphine but not to CER, thereby separating CER from the opioids. When water intake reducing doses of CER (15 nmol/kg) and FK 33–824 (850 nmol/kg) were combined, the two peptides were not additive but antagonized each other. Together, the present and previous results suggest that pharmacological inhibition of food and water intake have different characteristics.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(85)90366-8</identifier><identifier>PMID: 2998807</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analgesics ; Animals ; Biological and medical sciences ; Ceruletide ; Ceruletide - pharmacology ; D-Ala,MePhe,Met-ol-enkephalin ; Drinking - drug effects ; Eating - drug effects ; Enkephalin, Methionine - analogs & derivatives ; Enkephalin, Methionine - pharmacology ; FK 33–824 ; Male ; Medical sciences ; Mice ; Morphine ; Morphine - pharmacology ; Naloxone ; Naloxone - pharmacology ; Neuropharmacology ; Pharmacology. Drug treatments ; Receptors, Opioid - drug effects ; Receptors, Opioid - physiology ; Water intake</subject><ispartof>European journal of pharmacology, 1985-08, Vol.114 (3), p.247-251</ispartof><rights>1985</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-599b7b18b96e62544a5a2c02359b62d05cbff012d3bd5c86c7e2f7e42f532c5d3</citedby><cites>FETCH-LOGICAL-c386t-599b7b18b96e62544a5a2c02359b62d05cbff012d3bd5c86c7e2f7e42f532c5d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0014299985903668$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8557749$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2998807$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zetler, Gerhard</creatorcontrib><creatorcontrib>Raberg, Angela</creatorcontrib><title>Ceruletide inhibits water intake in deprived mice: Comparison with morphine and the enkephalin analogue, FK 33-824</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>Subcutaneous injections of ceruletide (caerulein diethylammonium hydrate, CER) reduced dose-dependently the water intake in male NMRI mice deprived of water for 18 h. The ED
50 for this effect was 5.5 (3.70–7.94) nmol/kg, which is 3.7 times more than the corresponding food intake inhibiting dose. Also inhibitory but much less potent than CER were (in decreasing order) FK 33–824, morphine and naloxone. Naloxone was an antagonist to both FK 33–824 and morphine but not to CER, thereby separating CER from the opioids. When water intake reducing doses of CER (15 nmol/kg) and FK 33–824 (850 nmol/kg) were combined, the two peptides were not additive but antagonized each other. Together, the present and previous results suggest that pharmacological inhibition of food and water intake have different characteristics.</description><subject>Analgesics</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Ceruletide</subject><subject>Ceruletide - pharmacology</subject><subject>D-Ala,MePhe,Met-ol-enkephalin</subject><subject>Drinking - drug effects</subject><subject>Eating - drug effects</subject><subject>Enkephalin, Methionine - analogs & derivatives</subject><subject>Enkephalin, Methionine - pharmacology</subject><subject>FK 33–824</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Morphine</subject><subject>Morphine - pharmacology</subject><subject>Naloxone</subject><subject>Naloxone - pharmacology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Receptors, Opioid - drug effects</subject><subject>Receptors, Opioid - physiology</subject><subject>Water intake</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEQhoMo67j6DxRyEFGwNZ3OpwdBBlfFBS96Dumk2o7bnW6T9C7-ezPOMEdPRVU9b5E8CD1tyZuWtOItIS1rqNb6peKvNOmEaNQ9tGuV1A2RLb2PdmfkIXqU8y9CCNeUX6CLOlOKyB1Ke0jbBCV4wCGOoQ8l4ztbINW22JvDFHtYU7gFj-fg4B3eL_NqU8hLxHehjHhe0jqGCNhGj8sIGOINrKOdatRGOy0_N3iNr77irmsUZY_Rg8FOGZ6c6iX6cfXx-_5zc_3t05f9h-vGdUqUhmvdy75VvRYgKGfMcksdoR3XvaCecNcPA2mp73rPnRJOAh0kMDrwjjruu0v04nh3TcvvDXIxc8gOpslGWLZspGCSU8kqyI6gS0vOCQZTvzvb9Me0xBxUm4NHc_BoFDf_VBtVY89O97d-Bn8OndzW_fPT3mZnpyHZ6EI-Y4pzKZmu2PsjBtXFbYBksgsQHfiQwBXjl_D_d_wFqVqaCA</recordid><startdate>19850827</startdate><enddate>19850827</enddate><creator>Zetler, Gerhard</creator><creator>Raberg, Angela</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19850827</creationdate><title>Ceruletide inhibits water intake in deprived mice: Comparison with morphine and the enkephalin analogue, FK 33-824</title><author>Zetler, Gerhard ; Raberg, Angela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-599b7b18b96e62544a5a2c02359b62d05cbff012d3bd5c86c7e2f7e42f532c5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Analgesics</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Ceruletide</topic><topic>Ceruletide - pharmacology</topic><topic>D-Ala,MePhe,Met-ol-enkephalin</topic><topic>Drinking - drug effects</topic><topic>Eating - drug effects</topic><topic>Enkephalin, Methionine - analogs & derivatives</topic><topic>Enkephalin, Methionine - pharmacology</topic><topic>FK 33–824</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Morphine</topic><topic>Morphine - pharmacology</topic><topic>Naloxone</topic><topic>Naloxone - pharmacology</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Receptors, Opioid - drug effects</topic><topic>Receptors, Opioid - physiology</topic><topic>Water intake</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zetler, Gerhard</creatorcontrib><creatorcontrib>Raberg, Angela</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zetler, Gerhard</au><au>Raberg, Angela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ceruletide inhibits water intake in deprived mice: Comparison with morphine and the enkephalin analogue, FK 33-824</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1985-08-27</date><risdate>1985</risdate><volume>114</volume><issue>3</issue><spage>247</spage><epage>251</epage><pages>247-251</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>Subcutaneous injections of ceruletide (caerulein diethylammonium hydrate, CER) reduced dose-dependently the water intake in male NMRI mice deprived of water for 18 h. The ED
50 for this effect was 5.5 (3.70–7.94) nmol/kg, which is 3.7 times more than the corresponding food intake inhibiting dose. Also inhibitory but much less potent than CER were (in decreasing order) FK 33–824, morphine and naloxone. Naloxone was an antagonist to both FK 33–824 and morphine but not to CER, thereby separating CER from the opioids. When water intake reducing doses of CER (15 nmol/kg) and FK 33–824 (850 nmol/kg) were combined, the two peptides were not additive but antagonized each other. Together, the present and previous results suggest that pharmacological inhibition of food and water intake have different characteristics.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2998807</pmid><doi>10.1016/0014-2999(85)90366-8</doi><tpages>5</tpages></addata></record> |
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| ispartof | European journal of pharmacology, 1985-08, Vol.114 (3), p.247-251 |
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| subjects | Analgesics Animals Biological and medical sciences Ceruletide Ceruletide - pharmacology D-Ala,MePhe,Met-ol-enkephalin Drinking - drug effects Eating - drug effects Enkephalin, Methionine - analogs & derivatives Enkephalin, Methionine - pharmacology FK 33–824 Male Medical sciences Mice Morphine Morphine - pharmacology Naloxone Naloxone - pharmacology Neuropharmacology Pharmacology. Drug treatments Receptors, Opioid - drug effects Receptors, Opioid - physiology Water intake |
| title | Ceruletide inhibits water intake in deprived mice: Comparison with morphine and the enkephalin analogue, FK 33-824 |
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