N-methyl- d-aspartate receptors modulate extracellular dopamine concentration and metabolism in rat hippocampus and striatum in vivo
The effects of infusingN-methyl- d-aspartate (NMDA), and the specific NMDA receptor antagonist d-2-amino-5-phosphonoproprionic acid ( d-AP5) into rat hippocampus and stiatum on extracellular dopamine (DA) and its metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were studied...
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| Veröffentlicht in: | Brain research 1994-01, Vol.635 (1), p.312-316 |
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| creator | Whitton, P.S. Maione, S. Biggs, C.S. Fowler, L.J. |
| description | The effects of infusingN-methyl-
d-aspartate (NMDA), and the specific NMDA receptor antagonist
d-2-amino-5-phosphonoproprionic acid (
d-AP5) into rat hippocampus and stiatum on extracellular dopamine (DA) and its metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were studied using intracerebral microdialysis. In striatum NMDA increased DA extracellularly in a concentration-dependent manner. Against a 10 μM concentration of NMDA the increase in striatal DA was opposed by
D-AP5 (10 μM in all experiments), which when infused alone significanlty reduced DA concentration. Infusion of NMDA and DOPAC level in a complex manner, with 10 μM concentration causing a significant increase 2 h after infusion, while 100 μM NMDA caused a transcient decrease in the metabolite. None of the treatments altered striatal dialysate HVA. In hippocampus NMDA infusion decreased dialysate DA concentration-dependent manner, and the decrease caused by 10 μM NMDA was reversed by
D-AP5. When given alone the antagonist was without effect. NMDA infusion elevated hippocampal dialysate DOPAC and HVA, while HVA was decreased following
D-AP5 infusion. These data indicate that DA release is reginally controlled by excitatory amino acids, but in differential manner. |
| doi_str_mv | 10.1016/0006-8993(94)91453-2 |
| format | Article |
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d-aspartate (NMDA), and the specific NMDA receptor antagonist
d-2-amino-5-phosphonoproprionic acid (
d-AP5) into rat hippocampus and stiatum on extracellular dopamine (DA) and its metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were studied using intracerebral microdialysis. In striatum NMDA increased DA extracellularly in a concentration-dependent manner. Against a 10 μM concentration of NMDA the increase in striatal DA was opposed by
D-AP5 (10 μM in all experiments), which when infused alone significanlty reduced DA concentration. Infusion of NMDA and DOPAC level in a complex manner, with 10 μM concentration causing a significant increase 2 h after infusion, while 100 μM NMDA caused a transcient decrease in the metabolite. None of the treatments altered striatal dialysate HVA. In hippocampus NMDA infusion decreased dialysate DA concentration-dependent manner, and the decrease caused by 10 μM NMDA was reversed by
D-AP5. When given alone the antagonist was without effect. NMDA infusion elevated hippocampal dialysate DOPAC and HVA, while HVA was decreased following
D-AP5 infusion. These data indicate that DA release is reginally controlled by excitatory amino acids, but in differential manner.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(94)91453-2</identifier><identifier>PMID: 8173968</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>3,4-Dihydroxyphenylacetic Acid - metabolism ; Alanine - administration & dosage ; Alanine - analogs & derivatives ; Animals ; Biological and medical sciences ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Corpus Striatum - metabolism ; DOPAC ; Dopamine ; Dopamine - metabolism ; Fundamental and applied biological sciences. Psychology ; Hippocampus - metabolism ; Homovanillic Acid - metabolism ; HVA ; Intracerebral dialysis ; Male ; Microdialysis ; N-Methylaspartate - administration & dosage ; NDMA ; Organophosphonates - administration & dosage ; Rats ; Rats, Wistar ; Receptors, N-Methyl-D-Aspartate - analysis ; Receptors, N-Methyl-D-Aspartate - physiology ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1994-01, Vol.635 (1), p.312-316</ispartof><rights>1994 Elsevier Science B.V. All rights reserved</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-42f369aff5d2c74e5bfb8d6c3abbba7dc4ed16939e3af718709b58b795ae31213</citedby><cites>FETCH-LOGICAL-c417t-42f369aff5d2c74e5bfb8d6c3abbba7dc4ed16939e3af718709b58b795ae31213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(94)91453-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3880739$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8173968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Whitton, P.S.</creatorcontrib><creatorcontrib>Maione, S.</creatorcontrib><creatorcontrib>Biggs, C.S.</creatorcontrib><creatorcontrib>Fowler, L.J.</creatorcontrib><title>N-methyl- d-aspartate receptors modulate extracellular dopamine concentration and metabolism in rat hippocampus and striatum in vivo</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The effects of infusingN-methyl-
d-aspartate (NMDA), and the specific NMDA receptor antagonist
d-2-amino-5-phosphonoproprionic acid (
d-AP5) into rat hippocampus and stiatum on extracellular dopamine (DA) and its metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were studied using intracerebral microdialysis. In striatum NMDA increased DA extracellularly in a concentration-dependent manner. Against a 10 μM concentration of NMDA the increase in striatal DA was opposed by
D-AP5 (10 μM in all experiments), which when infused alone significanlty reduced DA concentration. Infusion of NMDA and DOPAC level in a complex manner, with 10 μM concentration causing a significant increase 2 h after infusion, while 100 μM NMDA caused a transcient decrease in the metabolite. None of the treatments altered striatal dialysate HVA. In hippocampus NMDA infusion decreased dialysate DA concentration-dependent manner, and the decrease caused by 10 μM NMDA was reversed by
D-AP5. When given alone the antagonist was without effect. NMDA infusion elevated hippocampal dialysate DOPAC and HVA, while HVA was decreased following
D-AP5 infusion. These data indicate that DA release is reginally controlled by excitatory amino acids, but in differential manner.</description><subject>3,4-Dihydroxyphenylacetic Acid - metabolism</subject><subject>Alanine - administration & dosage</subject><subject>Alanine - analogs & derivatives</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Corpus Striatum - metabolism</subject><subject>DOPAC</subject><subject>Dopamine</subject><subject>Dopamine - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus - metabolism</subject><subject>Homovanillic Acid - metabolism</subject><subject>HVA</subject><subject>Intracerebral dialysis</subject><subject>Male</subject><subject>Microdialysis</subject><subject>N-Methylaspartate - administration & dosage</subject><subject>NDMA</subject><subject>Organophosphonates - administration & dosage</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, N-Methyl-D-Aspartate - analysis</subject><subject>Receptors, N-Methyl-D-Aspartate - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EKtvCPwDJB4TKIWDHTmJfKqGKL6mCC5ytiT1RjZI42M6K3vnhOLurPcLJGr_PjOx5CHnB2VvOePuOMdZWSmtxreUbzWUjqvoR2XHV1VVbS_aY7M7IU3KZ0s9SCqHZBblQvBO6VTvy52s1Yb5_GCvqKkgLxAwZaUSLSw4x0Sm4ddyu8HeOYHEcSxmpCwtMfkZqw2xxLlH2YaYwO1rmQR9GnybqZ1oCeu-XJViYljUdiJSjh7we8r3fh2fkyQBjwuen84r8-Pjh--3n6u7bpy-37-8qK3mXK1kPotUwDI2rbSex6YdeudYK6PseOmclOt5qoVHA0JU9MN03qu90Ayh4zcUVeX2cu8Twa8WUzeTT9iWYMazJdK3sGl6r_4K8VY1iTV1AeQRtDClFHMwS_QTxwXBmNktmU2A2BUZLc7BktraXp_lrP6E7N520lPzVKYdkYRwizNanMyaUYgUs2M0Rw7K0vcdokvVYfDhfBGbjgv_3O_4CZBKxcQ</recordid><startdate>19940128</startdate><enddate>19940128</enddate><creator>Whitton, P.S.</creator><creator>Maione, S.</creator><creator>Biggs, C.S.</creator><creator>Fowler, L.J.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19940128</creationdate><title>N-methyl- d-aspartate receptors modulate extracellular dopamine concentration and metabolism in rat hippocampus and striatum in vivo</title><author>Whitton, P.S. ; Maione, S. ; Biggs, C.S. ; Fowler, L.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-42f369aff5d2c74e5bfb8d6c3abbba7dc4ed16939e3af718709b58b795ae31213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>3,4-Dihydroxyphenylacetic Acid - metabolism</topic><topic>Alanine - administration & dosage</topic><topic>Alanine - analogs & derivatives</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Corpus Striatum - metabolism</topic><topic>DOPAC</topic><topic>Dopamine</topic><topic>Dopamine - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hippocampus - metabolism</topic><topic>Homovanillic Acid - metabolism</topic><topic>HVA</topic><topic>Intracerebral dialysis</topic><topic>Male</topic><topic>Microdialysis</topic><topic>N-Methylaspartate - administration & dosage</topic><topic>NDMA</topic><topic>Organophosphonates - administration & dosage</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, N-Methyl-D-Aspartate - analysis</topic><topic>Receptors, N-Methyl-D-Aspartate - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Whitton, P.S.</creatorcontrib><creatorcontrib>Maione, S.</creatorcontrib><creatorcontrib>Biggs, C.S.</creatorcontrib><creatorcontrib>Fowler, L.J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Whitton, P.S.</au><au>Maione, S.</au><au>Biggs, C.S.</au><au>Fowler, L.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>N-methyl- d-aspartate receptors modulate extracellular dopamine concentration and metabolism in rat hippocampus and striatum in vivo</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1994-01-28</date><risdate>1994</risdate><volume>635</volume><issue>1</issue><spage>312</spage><epage>316</epage><pages>312-316</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The effects of infusingN-methyl-
d-aspartate (NMDA), and the specific NMDA receptor antagonist
d-2-amino-5-phosphonoproprionic acid (
d-AP5) into rat hippocampus and stiatum on extracellular dopamine (DA) and its metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were studied using intracerebral microdialysis. In striatum NMDA increased DA extracellularly in a concentration-dependent manner. Against a 10 μM concentration of NMDA the increase in striatal DA was opposed by
D-AP5 (10 μM in all experiments), which when infused alone significanlty reduced DA concentration. Infusion of NMDA and DOPAC level in a complex manner, with 10 μM concentration causing a significant increase 2 h after infusion, while 100 μM NMDA caused a transcient decrease in the metabolite. None of the treatments altered striatal dialysate HVA. In hippocampus NMDA infusion decreased dialysate DA concentration-dependent manner, and the decrease caused by 10 μM NMDA was reversed by
D-AP5. When given alone the antagonist was without effect. NMDA infusion elevated hippocampal dialysate DOPAC and HVA, while HVA was decreased following
D-AP5 infusion. These data indicate that DA release is reginally controlled by excitatory amino acids, but in differential manner.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>8173968</pmid><doi>10.1016/0006-8993(94)91453-2</doi><tpages>5</tpages></addata></record> |
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| subjects | 3,4-Dihydroxyphenylacetic Acid - metabolism Alanine - administration & dosage Alanine - analogs & derivatives Animals Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Corpus Striatum - metabolism DOPAC Dopamine Dopamine - metabolism Fundamental and applied biological sciences. Psychology Hippocampus - metabolism Homovanillic Acid - metabolism HVA Intracerebral dialysis Male Microdialysis N-Methylaspartate - administration & dosage NDMA Organophosphonates - administration & dosage Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate - analysis Receptors, N-Methyl-D-Aspartate - physiology Vertebrates: nervous system and sense organs |
| title | N-methyl- d-aspartate receptors modulate extracellular dopamine concentration and metabolism in rat hippocampus and striatum in vivo |
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