Effect of FK506 on rat Leydig cell function—In vivo and in vitro study

FK506, a macrolide antibiotic, is a potent immunosuppressant and has a biological effect similar to that of cyclosporin A (CsA). In this study, the in vivo and in vitro effects of FK506 on rat Leydig cell function were investigated. In vivo, basal testosterone levels and secretion in response to hum...

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Veröffentlicht in:	Metabolism, clinical and experimental clinical and experimental, 1994-05, Vol.43 (5), p.533-537
Hauptverfasser:	Tai, Joseph, Tze, Wah Jun, Murase, Noriko, Starzl, Thomas E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chorionic Gonadotropin - pharmacology Drug toxicity and drugs side effects treatment Injections, Intramuscular Leydig Cells - drug effects Luteinizing Hormone - blood Male Medical sciences Osmolar Concentration Pharmacology. Drug treatments Rats Rats, Inbred ACI Rats, Wistar Reference Values Tacrolimus - pharmacology Testosterone - blood Time Factors Toxicity: urogenital system
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