Thrombin-induced endothelium-dependent inhibition and direct activation of platelet-vessel wall interaction : role of prostacyclin, nitric oxide, and thromboxane A2

Platelet-vessel wall interaction plays an important role in acute cardiovascular disorders. Thrombin is a potent platelet activator but also has profound effects on the endothelium. Endothelial cells possess antithrombotic activity by releasing nitric oxide and prostacyclin, both potent vasodilators...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1994-05, Vol.89 (5), p.2266-2272
Hauptverfasser:	ZHIHONG YANG, ARNET, U, BAUER, E, VON SEGESSER, L, SIEBENMANN, R, TURINA, M, LÜSCHER, T. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood vessels and receptors Coronary Vessels Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Epoprostenol - physiology Fundamental and applied biological sciences. Psychology Humans In Vitro Techniques Mammary Arteries Nitric Oxide - antagonists & inhibitors Nitric Oxide - physiology Platelet Activation - physiology Platelet Aggregation Inhibitors - pharmacology Thrombin - physiology Thromboxane A2 - physiology Vasoconstriction - drug effects Vasoconstriction - physiology Vertebrates: cardiovascular system
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