Effect of gamma-interferon on the clinical and biologic evolution of hypertrophic scars and Dupuytren's disease: an open pilot study
Hypertrophic scars and Dupuytren's disease are characterized by the presence of modified fibroblasts or myofibroblasts which are allegedly responsible for tissue retraction and excessive connective tissue production. gamma-Interferon, a cytokine produced by T-helper lymphocytes, has been shown...
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| Veröffentlicht in: | Plastic and reconstructive surgery (1963) 1994-05, Vol.93 (6), p.1224-1235 |
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| container_title | Plastic and reconstructive surgery (1963) |
| container_volume | 93 |
| creator | Pittet, B Rubbia-Brandt, L Desmoulière, A Sappino, A P Roggero, P Guerret, S Grimaud, J A Lacher, R Montandon, D Gabbiani, G |
| description | Hypertrophic scars and Dupuytren's disease are characterized by the presence of modified fibroblasts or myofibroblasts which are allegedly responsible for tissue retraction and excessive connective tissue production. gamma-Interferon, a cytokine produced by T-helper lymphocytes, has been shown to decrease fibroblast replication, alpha-smooth-muscle actin (the actin isoform characterizing myofibroblasts) expression, and collagen production. We have investigated in an open pilot study the possibility that intralesional injections of gamma-interferon exert a beneficial effect on the evolution of hypertrophic scars and Dupuytren's disease. In the 14 selected patients, gamma-interferon decreased the symptoms and the size of the lesions of both diseases; in hypertrophic scars, immunofluorescence examination showed that alpha-smooth-muscle actin expression also was decreased in myofibroblasts. Moreover, in fibroblasts cultured from 4 patients with hypertrophic scars, gamma-interferon decreased replication and alpha-smooth-muscle actin expression in vitro. Our results suggest that gamma-interferon could represent a useful adjunct to the nonsurgical therapy of hypertrophic scars and Dupuytren's disease. Larger controlled clinical studies, however, should test the validity of these preliminary observations. |
| doi_str_mv | 10.1097/00006534-199405000-00018 |
| format | Article |
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We have investigated in an open pilot study the possibility that intralesional injections of gamma-interferon exert a beneficial effect on the evolution of hypertrophic scars and Dupuytren's disease. In the 14 selected patients, gamma-interferon decreased the symptoms and the size of the lesions of both diseases; in hypertrophic scars, immunofluorescence examination showed that alpha-smooth-muscle actin expression also was decreased in myofibroblasts. Moreover, in fibroblasts cultured from 4 patients with hypertrophic scars, gamma-interferon decreased replication and alpha-smooth-muscle actin expression in vitro. Our results suggest that gamma-interferon could represent a useful adjunct to the nonsurgical therapy of hypertrophic scars and Dupuytren's disease. Larger controlled clinical studies, however, should test the validity of these preliminary observations.</description><identifier>ISSN: 0032-1052</identifier><identifier>DOI: 10.1097/00006534-199405000-00018</identifier><identifier>PMID: 8171142</identifier><language>eng</language><publisher>United States</publisher><subject>Actins - analysis ; Adult ; Cells, Cultured ; Cicatrix, Hypertrophic - drug therapy ; Cicatrix, Hypertrophic - pathology ; Dupuytren Contracture - drug therapy ; Dupuytren Contracture - pathology ; Female ; Fibroblasts - drug effects ; Fibroma - drug therapy ; Fibroma - pathology ; Humans ; Injections, Intralesional ; Interferon-gamma - administration & dosage ; Interferon-gamma - pharmacology ; Interferon-gamma - therapeutic use ; Male ; Microscopy, Fluorescence ; Middle Aged ; Muscle, Smooth - chemistry ; Myosins - analysis ; Pilot Projects ; Skin Neoplasms - drug therapy ; Skin Neoplasms - pathology</subject><ispartof>Plastic and reconstructive surgery (1963), 1994-05, Vol.93 (6), p.1224-1235</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8171142$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pittet, B</creatorcontrib><creatorcontrib>Rubbia-Brandt, L</creatorcontrib><creatorcontrib>Desmoulière, A</creatorcontrib><creatorcontrib>Sappino, A P</creatorcontrib><creatorcontrib>Roggero, P</creatorcontrib><creatorcontrib>Guerret, S</creatorcontrib><creatorcontrib>Grimaud, J A</creatorcontrib><creatorcontrib>Lacher, R</creatorcontrib><creatorcontrib>Montandon, D</creatorcontrib><creatorcontrib>Gabbiani, G</creatorcontrib><title>Effect of gamma-interferon on the clinical and biologic evolution of hypertrophic scars and Dupuytren's disease: an open pilot study</title><title>Plastic and reconstructive surgery (1963)</title><addtitle>Plast Reconstr Surg</addtitle><description>Hypertrophic scars and Dupuytren's disease are characterized by the presence of modified fibroblasts or myofibroblasts which are allegedly responsible for tissue retraction and excessive connective tissue production. gamma-Interferon, a cytokine produced by T-helper lymphocytes, has been shown to decrease fibroblast replication, alpha-smooth-muscle actin (the actin isoform characterizing myofibroblasts) expression, and collagen production. We have investigated in an open pilot study the possibility that intralesional injections of gamma-interferon exert a beneficial effect on the evolution of hypertrophic scars and Dupuytren's disease. In the 14 selected patients, gamma-interferon decreased the symptoms and the size of the lesions of both diseases; in hypertrophic scars, immunofluorescence examination showed that alpha-smooth-muscle actin expression also was decreased in myofibroblasts. Moreover, in fibroblasts cultured from 4 patients with hypertrophic scars, gamma-interferon decreased replication and alpha-smooth-muscle actin expression in vitro. Our results suggest that gamma-interferon could represent a useful adjunct to the nonsurgical therapy of hypertrophic scars and Dupuytren's disease. Larger controlled clinical studies, however, should test the validity of these preliminary observations.</description><subject>Actins - analysis</subject><subject>Adult</subject><subject>Cells, Cultured</subject><subject>Cicatrix, Hypertrophic - drug therapy</subject><subject>Cicatrix, Hypertrophic - pathology</subject><subject>Dupuytren Contracture - drug therapy</subject><subject>Dupuytren Contracture - pathology</subject><subject>Female</subject><subject>Fibroblasts - drug effects</subject><subject>Fibroma - drug therapy</subject><subject>Fibroma - pathology</subject><subject>Humans</subject><subject>Injections, Intralesional</subject><subject>Interferon-gamma - administration & dosage</subject><subject>Interferon-gamma - pharmacology</subject><subject>Interferon-gamma - therapeutic use</subject><subject>Male</subject><subject>Microscopy, Fluorescence</subject><subject>Middle Aged</subject><subject>Muscle, Smooth - chemistry</subject><subject>Myosins - analysis</subject><subject>Pilot Projects</subject><subject>Skin Neoplasms - drug therapy</subject><subject>Skin Neoplasms - pathology</subject><issn>0032-1052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtPxCAQxzlodF39CCac9FTlUUrrzazPxMSLnhsKg4tpSwVqsnc_uOiukgHm8Z-Z5IcQpuSCkkZeknwqwcuCNk1JRI6KfGm9hxaEcFZQItghOorxPWclr8QBOqippLRkC_R1ay3ohL3Fb2oYVOHGBMFC8CPOltaAde9Gp1WP1Whw53zv35zG8On7ObkfmcXrzQQhBT-tcyVqFeKv-Gae5k0KMJ5HbFwEFeEqF7CfYMST633CMc1mc4z2reojnOz-JXq9u31ZPRRPz_ePq-unQjMhUgESStEZ3tTZIRJAV7WygnOTX8EsgBGMipp2ktsGoJKMQs2M7cDkCYov0dl27hT8xwwxtYOLGvpejeDn2MqqlJxVTRbWW6EOPsYAtp2CG1TYtJS0P9DbP-jtP_T2F3puPd3tmLsBzH_jjjj_BpNkgg8</recordid><startdate>19940501</startdate><enddate>19940501</enddate><creator>Pittet, B</creator><creator>Rubbia-Brandt, L</creator><creator>Desmoulière, A</creator><creator>Sappino, A P</creator><creator>Roggero, P</creator><creator>Guerret, S</creator><creator>Grimaud, J A</creator><creator>Lacher, R</creator><creator>Montandon, D</creator><creator>Gabbiani, G</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940501</creationdate><title>Effect of gamma-interferon on the clinical and biologic evolution of hypertrophic scars and Dupuytren's disease: an open pilot study</title><author>Pittet, B ; Rubbia-Brandt, L ; Desmoulière, A ; Sappino, A P ; Roggero, P ; Guerret, S ; Grimaud, J A ; Lacher, R ; Montandon, D ; Gabbiani, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c255t-e7e45bd3987e407eec68af533daf552feed521581b73f9ee6721e82dfbedc25a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Actins - analysis</topic><topic>Adult</topic><topic>Cells, Cultured</topic><topic>Cicatrix, Hypertrophic - drug therapy</topic><topic>Cicatrix, Hypertrophic - pathology</topic><topic>Dupuytren Contracture - drug therapy</topic><topic>Dupuytren Contracture - pathology</topic><topic>Female</topic><topic>Fibroblasts - drug effects</topic><topic>Fibroma - drug therapy</topic><topic>Fibroma - pathology</topic><topic>Humans</topic><topic>Injections, Intralesional</topic><topic>Interferon-gamma - administration & dosage</topic><topic>Interferon-gamma - pharmacology</topic><topic>Interferon-gamma - therapeutic use</topic><topic>Male</topic><topic>Microscopy, Fluorescence</topic><topic>Middle Aged</topic><topic>Muscle, Smooth - chemistry</topic><topic>Myosins - analysis</topic><topic>Pilot Projects</topic><topic>Skin Neoplasms - drug therapy</topic><topic>Skin Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pittet, B</creatorcontrib><creatorcontrib>Rubbia-Brandt, L</creatorcontrib><creatorcontrib>Desmoulière, A</creatorcontrib><creatorcontrib>Sappino, A P</creatorcontrib><creatorcontrib>Roggero, P</creatorcontrib><creatorcontrib>Guerret, S</creatorcontrib><creatorcontrib>Grimaud, J A</creatorcontrib><creatorcontrib>Lacher, R</creatorcontrib><creatorcontrib>Montandon, D</creatorcontrib><creatorcontrib>Gabbiani, G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Plastic and reconstructive surgery (1963)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pittet, B</au><au>Rubbia-Brandt, L</au><au>Desmoulière, A</au><au>Sappino, A P</au><au>Roggero, P</au><au>Guerret, S</au><au>Grimaud, J A</au><au>Lacher, R</au><au>Montandon, D</au><au>Gabbiani, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of gamma-interferon on the clinical and biologic evolution of hypertrophic scars and Dupuytren's disease: an open pilot study</atitle><jtitle>Plastic and reconstructive surgery (1963)</jtitle><addtitle>Plast Reconstr Surg</addtitle><date>1994-05-01</date><risdate>1994</risdate><volume>93</volume><issue>6</issue><spage>1224</spage><epage>1235</epage><pages>1224-1235</pages><issn>0032-1052</issn><abstract>Hypertrophic scars and Dupuytren's disease are characterized by the presence of modified fibroblasts or myofibroblasts which are allegedly responsible for tissue retraction and excessive connective tissue production. gamma-Interferon, a cytokine produced by T-helper lymphocytes, has been shown to decrease fibroblast replication, alpha-smooth-muscle actin (the actin isoform characterizing myofibroblasts) expression, and collagen production. We have investigated in an open pilot study the possibility that intralesional injections of gamma-interferon exert a beneficial effect on the evolution of hypertrophic scars and Dupuytren's disease. In the 14 selected patients, gamma-interferon decreased the symptoms and the size of the lesions of both diseases; in hypertrophic scars, immunofluorescence examination showed that alpha-smooth-muscle actin expression also was decreased in myofibroblasts. Moreover, in fibroblasts cultured from 4 patients with hypertrophic scars, gamma-interferon decreased replication and alpha-smooth-muscle actin expression in vitro. Our results suggest that gamma-interferon could represent a useful adjunct to the nonsurgical therapy of hypertrophic scars and Dupuytren's disease. 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| subjects | Actins - analysis Adult Cells, Cultured Cicatrix, Hypertrophic - drug therapy Cicatrix, Hypertrophic - pathology Dupuytren Contracture - drug therapy Dupuytren Contracture - pathology Female Fibroblasts - drug effects Fibroma - drug therapy Fibroma - pathology Humans Injections, Intralesional Interferon-gamma - administration & dosage Interferon-gamma - pharmacology Interferon-gamma - therapeutic use Male Microscopy, Fluorescence Middle Aged Muscle, Smooth - chemistry Myosins - analysis Pilot Projects Skin Neoplasms - drug therapy Skin Neoplasms - pathology |
| title | Effect of gamma-interferon on the clinical and biologic evolution of hypertrophic scars and Dupuytren's disease: an open pilot study |
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