Intracellular transport of asialoglycoproteins in rat hepatocytes: Evidence for two subpopulations of lysosomes

The intracellular transport and degradation of asialoorosomucoid (AOM) in isolated rat hepatocytes was studied by means of subcellular fractionation in Nycodenz gradients. The asialoglycoprotein was labelled by covalent attachment of a radioiodinated tyraminecellobiose adduct ([ 125I]TC) which leads...

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Veröffentlicht in:	Experimental cell research 1985-12, Vol.161 (2), p.285-296
Hauptverfasser:	Berg, Trond, Kindberg, Grete M., Ford, Terry, Blomhoff, Rune
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Asialoglycoproteins Biological and medical sciences Cell Fractionation Cell physiology Cellobiose Cells, Cultured Colchicine - pharmacology Depression, Chemical Fundamental and applied biological sciences. Psychology Leupeptins - pharmacology Liver - metabolism Liver - ultrastructure Lysosomes - classification Lysosomes - drug effects Lysosomes - metabolism Male Membrane and intracellular transports Molecular and cellular biology Monensin - pharmacology Orosomucoid - analogs & derivatives Orosomucoid - metabolism Rats Rats, Inbred Strains Tyramine
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