Thromboxane A2 and prostaglandin endoperoxide receptors in platelets and vascular smooth muscle

9,11-Dimethylmethano-11,12-methano-16-(3-iodo-4-hydroxyphenyl)-13, 14-dihydro-13-aza-15 alpha beta-omega-tetranor-TXA2 (I-PTA-OH), a recently synthesized thromboxane (TX) A2/prostaglandin (PG) H2 receptor antagonist, was shown to be a competitive antagonist of human platelet aggregation induced by t...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1985-12, Vol.72 (6), p.1202-1207
Hauptverfasser:	Saussy, Jr, D L, Mais, D E, Knapp, D R, Halushka, P V
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid Blood Platelets - analysis Humans Iodine Radioisotopes Male Muscle, Smooth, Vascular - analysis Platelet Aggregation - drug effects Prostaglandin Endoperoxides - pharmacology Prostaglandin Endoperoxides, Synthetic - pharmacology Radioligand Assay Receptors, Cell Surface - analysis Receptors, Prostaglandin - analysis Receptors, Prostaglandin - drug effects Receptors, Thromboxane Structure-Activity Relationship Thromboxane A2 - analogs & derivatives Thromboxane A2 - pharmacology
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